Stack and topography verification as an enabler for computational metrology target design

2015 ◽  
Author(s):  
Michael E. Adel ◽  
Inna Tarshish-Shapir ◽  
David Gready ◽  
Mark Ghinovker ◽  
Chen Dror ◽  
...  
2016 ◽  
Author(s):  
Jianming Zhou ◽  
Sarah Wu ◽  
Craig Hickman ◽  
Ewoud van West ◽  
Maurits van der Schaar ◽  
...  

2004 ◽  
Vol 22 (1) ◽  
pp. 19-24 ◽  
Author(s):  
F. PEGORARO ◽  
S. ATZENI ◽  
M. BORGHESI ◽  
S. BULANOV ◽  
T. ESIRKEPOV ◽  
...  

Energetic ion beams are produced during the interaction of ultrahigh-intensity, short laser pulses with plasmas. These laser-produced ion beams have important applications ranging from the fast ignition of thermonuclear targets to proton imaging, deep proton lithography, medical physics, and injectors for conventional accelerators. Although the basic physical mechanisms of ion beam generation in the plasma produced by the laser pulse interaction with the target are common to all these applications, each application requires a specific optimization of the ion beam properties, that is, an appropriate choice of the target design and of the laser pulse intensity, shape, and duration.


Author(s):  
Łukasz Piotr Baran ◽  
Wojciech Rżysko ◽  
Dariusz Tarasewicz

In this study we have performed extensive coarse-grained molecular dynamics simulations of the self-assembly of tetra-substituted molecules. We have found that such molecules are able to form a variety of...


2011 ◽  
Vol 133 (1) ◽  
Author(s):  
Steven Turek ◽  
Sam Anand

Digital measurement devices, such as coordinate measuring machines, laser scanning devices, and digital imaging, can provide highly accurate and precise coordinate data representing the sampled surface. However, this discrete measurement process can only account for measured data points, not the entire continuous form, and is heavily influenced by the algorithm that interprets the measured data. The definition of cylindrical size for an external feature as specified by ASME Y14.5.1M-1994 [The American Society of Mechanical Engineers, 1995, Dimensioning and Tolerancing, ASME Standard Y14.5M-1994, ASME, New York, NY; The American Society of Mechanical Engineers, 1995, Mathematical Definition of Dimensioning and Tolerancing Principles, ASME Standard Y14.5.1M-1994, ASME, New York, NY] matches the analytical definition of a minimum circumscribing cylinder (MCC) when rule no. 1 [The American Society of Mechanical Engineers, 1995, Dimensioning and Tolerancing, ASME Standard Y14.5M-1994, ASME, New York, NY; The American Society of Mechanical Engineers, 1995, Mathematical Definition of Dimensioning and Tolerancing Principles, ASME Standard Y14.5.1M-1994, ASME, New York, NY] is applied to ensure a linear axis. Even though the MCC is a logical choice for size determination, it is highly sensitive to the sampling method and any uncertainties encountered in that process. Determining the least-sum-of-squares solution is an alternative method commonly utilized in size determination. However, the least-squares formulation seeks an optimal solution not based on the cylindrical size definition [The American Society of Mechanical Engineers, 1995, Dimensioning and Tolerancing, ASME Standard Y14.5M-1994, ASME, New York, NY; The American Society of Mechanical Engineers, 1995, Mathematical Definition of Dimensioning and Tolerancing Principles, ASME Standard Y14.5.1M-1994, ASME, New York, NY] and thus has been shown to be biased [Hopp, 1993, “Computational Metrology,” Manuf. Rev., 6(4), pp. 295–304; Nassef, and ElMaraghy, 1999, “Determination of Best Objective Function for Evaluating Geometric Deviations,” Int. J. Adv. Manuf. Technol., 15, pp. 90–95]. This work builds upon previous research in which the hull normal method was presented to determine the size of cylindrical bosses when rule no. 1 is applied [Turek, and Anand, 2007, “A Hull Normal Approach for Determining the Size of Cylindrical Features,” ASME, Atlanta, GA]. A thorough analysis of the hull normal method’s performance in various circumstances is presented here to validate it as a superior alternative to the least-squares and MCC solutions for size evaluation. The goal of the hull normal method is to recreate the sampled surface using computational geometry methods and to determine the cylinder’s axis and radius based upon it. Based on repetitive analyses of random samples of data from several measured parts and generated forms, it was concluded that the hull normal method outperformed all traditional solution methods. The hull normal method proved to be robust by having a lower bias and distributions that were skewed toward the true value of the radius, regardless of the amount of form error.


Author(s):  
Miguel A. Losada ◽  
M. Izaskun Benedicto
Keyword(s):  

2021 ◽  
Author(s):  
◽  
Oliver Wright

<p>This research investigates a progression away from acoustics formed by spaces and towards spaces that are driven by target acoustics. Despite architecture and acoustics’ shared consideration of form, materiality and inhabitation, too often acoustics is neglected from design and so is treated remedially, nullifying creativity. A case study project was undertaken to investigate the opportunities and limitations of two parametric tools, Galapagos (a generative solver) and Pachyderm (an acoustic simulation tool), to develop acoustic qualities in early architectural design. Yet, what are these acoustic qualities and how could they be measured? Testing of cafes in the Wellington CBD was undertaken to investigate these questions.  Six cafes were acoustically tested and five patrons from each of these completed a subjective survey. The café testing suggested that Reverberation Time (RT) could be an effective acoustic measure to direct architectural design. The café with the lowest patron enjoyment rating also recorded the longest RT and highest Sound Pressure Level (SPL), reinforcing the relationship between these three elements. Through these findings, patron enjoyment was concluded to be dependent on SPL and SPL was concluded to be dependent on RT (Whitlock and Dodd, 424). In order to increase patron enjoyment, Galapagos was utilised to explore possible forms that met a target design RT of 0.7 seconds. An RT of 0.7 seconds was chosen as it was shorter than the AS/NZS 2107 (2000) maximum and was comparable to the cafés with the two highest subjective enjoyment ratings.  Through a parametric and analogue design methodology, Galapagos and Pachyderm were used to investigate how acoustic goals could shape a café design. The case study project produced a design that not only meets this acoustic criterion but harnesses form to sculpt sound. Instead of applying absorption to flat surfaces, the convex curves on the north and east facades disperse sound, producing both a diffuse environment and an engaging architectural element. This integrated investigation demonstrated that a parametric and analogue design process can be implemented to create a acoustically and architecturally effective design.</p>


2019 ◽  
Author(s):  
Kendall R Sanson ◽  
Peter C DeWeirdt ◽  
Annabel K Sangree ◽  
Ruth E Hanna ◽  
Mudra Hegde ◽  
...  

ABSTRACTCas12a enzymes have attractive properties for scalable delivery of multiplexed perturbations, yet widespread usage has lagged behind Cas9-based strategies. Here we describe the optimization of Cas12a from Acidaminococcus (AsCas12a) for use in pooled genetic screens in human cells. By assaying the activity of thousands of guides, we confirm on-target design rules and extend them to an enhanced activity variant, enAsCas12a. We also develop the first comprehensive set of off-target rules for Cas12a, and demonstrate that we can predict and exclude promiscuous guides. Finally, to enable efficient higher-order multiplexing via lentiviral delivery, we screen thousands of direct repeat variants and identify 38 that outperform the wildtype sequence. We validate this optimized AsCas12a toolkit by targeting 12 synthetic lethal gene pairs with up to 400 guide pairs each, and demonstrate effective triple knockout via flow cytometry. These results establish AsCas12a as a robust system for combinatorial applications of CRISPR technology.


2019 ◽  
Author(s):  
Forrest Robert Svingala ◽  
Mario Valles Montenegro
Keyword(s):  

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