The immunological response created by interstitial and non-invasive laser immunotherapy

2015 ◽  
Author(s):  
Cody F. Bahavar ◽  
Feifan Zhou ◽  
Aamr M. Hasanjee ◽  
Connor L. West ◽  
Robert E. Nordquist ◽  
...  
Keyword(s):  
Immunological Response ◽  
Non Invasive ◽  
Laser Immunotherapy

scholarly journals Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines

Pharmaceutics ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 45
Author(s):  
Iman M. Alfagih ◽  
Basmah Aldosari ◽  
Bushra AlQuadeib ◽  
Alanood Almurshedi ◽  
Mariyam M. Alfagih
Keyword(s):  
Messenger Rna ◽  
Immune Cell ◽  
Natural Infection ◽  
Immunological Response ◽  
Infection Process ◽  
Dual Function ◽  
Therapeutic Vaccines ◽  
Non Invasive ◽  
Recent Developments

Messenger RNA (mRNA)-based vaccines have shown promise against infectious diseases and several types of cancer in the last two decades. Their promise can be attributed to their safety profiles, high potency, and ability to be rapidly and affordably manufactured. Now, many RNA-based vaccines are being evaluated in clinical trials as prophylactic and therapeutic vaccines. However, until recently, their development has been limited by their instability and inefficient in vivo transfection. The nanodelivery system plays a dual function in RNA-based vaccination by acting as a carrier system and as an adjuvant. That is due to its similarity to microorganisms structurally and size-wise; the nanodelivery system can augment the response by the immune system via simulating the natural infection process. Nanodelivery systems allow non-invasive mucosal administration, targeted immune cell delivery, and controlled delivery, reducing the need for multiple administrations. They also allow co-encapsulating with immunostimulators to improve the overall adjuvant capacity. The aim of this review is to discuss the recent developments and applications of biodegradable nanodelivery systems that improve RNA-based vaccine delivery and enhance the immunological response against targeted diseases.

scholarly journals Non-Invasive Detection of Anastomotic Leakage Following Esophageal and Pancreatic Surgery by Urinary Analysis

2018 ◽  
Vol 36 (2) ◽  
pp. 173-180 ◽  
Author(s):  
Victor D. Plat ◽  
Nora van Gaal ◽  
James A. Covington ◽  
Matthew Neal ◽  
Tim G.J. de Meij ◽  
...  
Keyword(s):  
Anastomotic Leakage ◽  
Area Under The Curve ◽  
Pancreatic Head ◽  
Postoperative Mortality ◽  
Immunological Response ◽  
International Study ◽  
Study Groups ◽  
Delay In Diagnosis ◽  
Non Invasive ◽  
Urinary Analysis

Background: Esophagectomy or pancreaticoduodenectomy is the standard surgical approach for patients with tumors of the esophagus or pancreatic head. Postoperative mortality is strongly correlated with the occurrence of anastomotic leakage (AL). Delay in diagnosis leads to delay in treatment, which ratifies the need for development of novel and accurate non-invasive diagnostic tests for detection of AL. Urinary volatile organic compounds (VOCs) reflect the metabolic status of an individual, which is associated with a systemic immunological response. The aim of this study was to determine the diagnostic accuracy of urinary VOCs to detect AL after esophagectomy or pancreaticoduodenectomy. Methods: In the present study, urinary VOCs of 63 patients after esophagectomy (n = 31) or pancreaticoduodenectomy (n = 32) were analyzed by means of field asymmetric ion mobility spectrometry. AL was defined according to international study groups. Results: AL was observed in 15 patients (24%). Urinary VOCs of patients with AL after pancreaticoduodenectomy could be distinguished from uncomplicated controls, area under the curve 0.85 (95% CI 0.76–0.93), sensitivity 76%, and specificity 77%. However, this was not observed following esophagectomy, area under the curve 0.51 (95% CI 0.37–0.65). Conclusion: In our study population AL following pancreaticoduodenectomy could be discriminated from uncomplicated controls by means of urinary VOC analysis, NTC03203434.

scholarly journals ANTI-TUMOR RESPONSES INDUCED BY LASER IRRADIATION AND IMMUNOLOGICAL STIMULATION USING A MOUSE MAMMARY TUMOR MODEL

2013 ◽  
Vol 06 (04) ◽  
pp. 1350039 ◽  
Author(s):  
FEIFAN ZHOU ◽  
XIAOSONG LI ◽  
SHENG SONG ◽  
JOSEPH T. ACQUAVIVA ◽  
ROMAN F. WOLF ◽  
...  
Keyword(s):  
Local Treatment ◽  
Immunological Response ◽  
Tumor Model ◽  
Laser Absorption ◽  
Mouse Mammary Tumor ◽  
Tnf Α ◽  
Mammary Tumor Model ◽  
Laser Immunotherapy ◽  
Adoptive Immunity ◽  
High Level

Anti-tumor immunological response induced by local intervention is ideal for treatment of metastatic tumors. Laser immunotherapy was developed to synergize photothermal interaction with immunological stimulation for cancer treatment. Using an infrared laser, indocyanine green (ICG, as a light absorbing agent), and glycated chitosan (GC, as an immunostimulant), laser immunotherapy has resulted in tumor suppression and anti-tumor responses in pre-clinical as well as clinical studies. To further understand the mechanism of laser immunotherapy, the effects of laser and GC treatment without specific enhancement of laser absorption were studied. Passive adoptive immunity transfer was performed using splenocytes as immune cells. Spleen cells harvested from tumor-bearing mice treated by laser + GC provided 60% immunity in naive recipients. Furthermore, cytotoxicity and TNF-α secretion by splenocytes from treated mice also indicated that laser + G induced immunity was tumor-specific. The high level of infiltrating T cells in tumors after laser + GC treatment further confirmed a specific anti-tumor immune response. Therefore, laser + GC could prove to be a promising selective local treatment modality that induces a systemic anti-tumor response, with appropriate laser parameters and GC doses.

Current concepts in the management of paediatric rhinosinusitis

1999 ◽  
Vol 113 (1) ◽  
pp. 1-9 ◽  
Author(s):  
N. S. Jones
Keyword(s):  
Immunological Response ◽  
Nasal Discharge ◽  
Adenoid Hypertrophy ◽  
Upper Respiratory Tract ◽  
Subperiosteal Abscess ◽  
Non Invasive ◽  
Age Appropriate ◽  
Upper Respiratory ◽  
Repeated Infections ◽  
Tract Infections

AbstractIt is well recognized that adenoid hypertrophy and allergic rhinitis are common in children and that recurrent upper respiratory tract infections are a fact of life. The main causes of symptoms associated with rhinosinusitis in children are rhinorrhoea, nasal obstruction, mouth breathing, hyponasal speech and snoring. Most children grow out of adenoid hypertrophy and recurrent colds by the age of eight to 10 and this means that the main treatment strategy should therefore be conservative and not surgical. An explanation to anxious parents, simple non-invasive measures such as teaching nose-blowing, the use of saline sprays or a trial of allergen avoidance and age-appropriate topical nasal anti-inflammatory sprays should be tried before surgery is even contemplated. Because repeated infections are so common, antibiotics given for chronic nasal discharge often have only short-lived effects.Rhinosinusitis in children is not a surgical disease and ‘watchful waiting’ is advised. Any treatment should first of all be safe, as even without any intervention the problem usually resolves with time. It is likely that growth and maturation of the immunological response to pathogens play a major role in resolution of the disease. There are few exceptions to this principle: nasal polyps (indicating possible cystic fibrosis), and periorbital cellulitis where an assessment of vision, parenteral antibiotics, and if there is concern about the possibility of a subperiosteal abscess, computerized tomography (CT) and drainage of any pus is indicated.

X-ray microtomography

1988 ◽  
Vol 46 ◽  
pp. 998-999
Author(s):  
H.W. Deckman ◽  
B.F. Flannery ◽  
J.H. Dunsmuir ◽  
K.D' Amico
Keyword(s):  
Computed Tomography ◽  
Internal Structure ◽  
Imaging Technique ◽  
Three Dimensional ◽  
Tissue Structure ◽  
Individual Element ◽  
X Ray ◽  
Non Invasive ◽  
Panoramic Imaging ◽  
Three Dimensional Images

We have developed a new X-ray microscope which produces complete three dimensional images of samples. The microscope operates by performing X-ray tomography with unprecedented resolution. Tomography is a non-invasive imaging technique that creates maps of the internal structure of samples from measurement of the attenuation of penetrating radiation. As conventionally practiced in medical Computed Tomography (CT), radiologists produce maps of bone and tissue structure in several planar sections that reveal features with 1mm resolution and 1% contrast. Microtomography extends the capability of CT in several ways. First, the resolution which approaches one micron, is one thousand times higher than that of the medical CT. Second, our approach acquires and analyses the data in a panoramic imaging format that directly produces three-dimensional maps in a series of contiguous stacked planes. Typical maps available today consist of three hundred planar sections each containing 512x512 pixels. Finally, and perhaps of most import scientifically, microtomography using a synchrotron X-ray source, allows us to generate maps of individual element.

Non-invasive measurement of a fermentation pattern shift in infants during the first three months of life

2001 ◽  
Vol 120 (5) ◽  
pp. A266-A266
Author(s):  
R BUTLER ◽  
B ZACHARAKIS ◽  
D MOORE ◽  
K CRAWFORD ◽  
G DAVIDSON ◽  
...  
Keyword(s):  
Non Invasive ◽  
Fermentation Pattern ◽  
Invasive Measurement

European multicentre validation trial of two new non-invasive tests for detection of antibody to H. pylori: Urine-based ELISA and rapid urine test

2001 ◽  
Vol 120 (5) ◽  
pp. A491-A491 ◽  
Author(s):  
A LEODOLTER ◽  
D VAIRA ◽  
F BAZZOLL ◽  
A HIRSCHL ◽  
F MEGRAUD ◽  
...  
Keyword(s):  
Urine Test ◽  
Non Invasive ◽  
H Pylori

Tu1996 NON-INVASIVE BREATH TEST SCREENING TO ASSESS FOR PREPROCEDURAL FASTING USING AN ELECTRONIC NOSE: AN UPDATE

2020 ◽  
Vol 158 (6) ◽  
pp. S-1249
Author(s):  
Yuri Hanada ◽  
Juan Reyes Genere ◽  
Bryan Linn ◽  
Tiffany Mangels-Dick ◽  
Kenneth K. Wang
Keyword(s):  
Electronic Nose ◽  
Breath Test ◽  
Non Invasive

1307: Renal Radiosurgery and Sorafenib as Non-Invasive Nephron-Sparing Treatment of Small Localized Renal Masses

2007 ◽  
Vol 177 (4S) ◽  
pp. 430-430
Author(s):  
Ram Ganapathi ◽  
Troy R. Gianduzzo ◽  
Arul Mahadevan ◽  
Monish Aron ◽  
Lee E. Ponsky ◽  
...  
Keyword(s):  
Renal Masses ◽  
Non Invasive ◽  
Nephron Sparing
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