scholarly journals Communication of brain network core connections altered in behavioral variant frontotemporal dementia but possibly preserved in early-onset Alzheimer's disease

2015 ◽  
Author(s):  
Madelaine Daianu ◽  
Neda Jahanshad ◽  
Mario F. Mendez ◽  
George Bartzokis ◽  
Elvira E. Jimenez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Brain Network ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Early Onset Alzheimer’S Disease

scholarly journals Disrupted rich club network in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease

2015 ◽  
Vol 37 (3) ◽  
pp. 868-883 ◽  
Author(s):  
Madelaine Daianu ◽  
Adam Mezher ◽  
Mario F. Mendez ◽  
Neda Jahanshad ◽  
Elvira E. Jimenez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Rich Club ◽  
Early Onset Alzheimer’S Disease

Distinct social-behavioral changes in frontotemporal dementia and early onset Alzheimer's disease

2014 ◽  
Author(s):  
Joseph P. Barsuglia ◽  
Michelle J. Mather ◽  
Hemali V. Panchal ◽  
Aditi Joshi ◽  
Elvira Jimenez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Behavioral Changes ◽  
Early Onset Alzheimer’S Disease

scholarly journals Distinct network topology in Alzheimer’s disease and behavioral variant frontotemporal dementia

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Adeline Su Lyn Ng ◽  
Juan Wang ◽  
Kwun Kei Ng ◽  
Joanna Su Xian Chong ◽  
Xing Qian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Network Topology ◽  
Neuropsychiatric Symptoms ◽  
Brain Network ◽  
Salience Network ◽  
Behavioral Variant Frontotemporal Dementia ◽  
Control Networks ◽  
And Control

Abstract Background Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) cause distinct atrophy and functional disruptions within two major intrinsic brain networks, namely the default network and the salience network, respectively. It remains unclear if inter-network relationships and whole-brain network topology are also altered and underpin cognitive and social–emotional functional deficits. Methods In total, 111 participants (50 AD, 14 bvFTD, and 47 age- and gender-matched healthy controls) underwent resting-state functional magnetic resonance imaging (fMRI) and neuropsychological assessments. Functional connectivity was derived among 144 brain regions of interest. Graph theoretical analysis was applied to characterize network integration, segregation, and module distinctiveness (degree centrality, nodal efficiency, within-module degree, and participation coefficient) in AD, bvFTD, and healthy participants. Group differences in graph theoretical measures and empirically derived network community structures, as well as the associations between these indices and cognitive performance and neuropsychiatric symptoms, were subject to general linear models, with age, gender, education, motion, and scanner type controlled. Results Our results suggested that AD had lower integration in the default and control networks, while bvFTD exhibited disrupted integration in the salience network. Interestingly, AD and bvFTD had the highest and lowest degree of integration in the thalamus, respectively. Such divergence in topological aberration was recapitulated in network segregation and module distinctiveness loss, with AD showing poorer modular structure between the default and control networks, and bvFTD having more fragmented modules in the salience network and subcortical regions. Importantly, aberrations in network topology were related to worse attention deficits and greater severity in neuropsychiatric symptoms across syndromes. Conclusions Our findings underscore the reciprocal relationships between the default, control, and salience networks that may account for the cognitive decline and neuropsychiatric symptoms in dementia.

scholarly journals P2-292: THE PATTERN OF INHERITANCE IN EARLY ONSET ALZHEIMER'S DISEASE AND FRONTOTEMPORAL DEMENTIA

2019 ◽  
Vol 15 ◽  
pp. P698-P698
Author(s):  
Gorana Mandic Stojmenovic ◽  
Elka Stefanova ◽  
Ivana Novakovic ◽  
Valerija Dobricic ◽  
Tanja Stojkovic ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Early Onset Alzheimer’S Disease

CSF Neurofilaments in Frontotemporal Dementia Compared with Early Onset Alzheimer’s Disease and Controls

2007 ◽  
Vol 23 (4) ◽  
pp. 225-230 ◽  
Author(s):  
Yolande A.L. Pijnenburg ◽  
John C. Janssen ◽  
Niki S.M. Schoonenboom ◽  
Axel Petzold ◽  
Cees Mulder ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Early Onset Alzheimer’S Disease

scholarly journals R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

2014 ◽  
Vol 10 (6) ◽  
pp. 602-608.e4 ◽  
Author(s):  
Catherine F. Slattery ◽  
Jonathan A. Beck ◽  
Lorna Harper ◽  
Gary Adamson ◽  
Zeinab Abdi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Early Onset Alzheimer’S Disease
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