Co-focused ultrasound and optical coherence elastography system for the study of age-related changes of biomechanical properties of crystalline lens in rabbit eyes

2015 ◽  
Author(s):  
Chen Wu ◽  
Zhaolong Han ◽  
Shang Wang ◽  
Jiasong Li ◽  
Manmohan Singh ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Crystalline Lens ◽  
Biomechanical Properties ◽  
Optical Coherence ◽  
Age Related ◽  
Age Related Changes

scholarly journals Elasticity Changes in the Crystalline Lens during Oxidative Damage and the Antioxidant Effect of Alpha-Lipoic Acid Measured by Optical Coherence Elastography

Photonics ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 207
Author(s):  
Hongqiu Zhang ◽  
Manmohan Singh ◽  
Achuth Nair ◽  
Kirill V. Larin ◽  
Salavat R. Aglyamov
Keyword(s):  
Oxidative Damage ◽  
Young’S Modulus ◽  
Lipoic Acid ◽  
Ex Vivo ◽  
Young's Modulus ◽  
Crystalline Lens ◽  
Biomechanical Properties ◽  
Optical Coherence ◽  
Age Related ◽  
Significant Difference

Age-related cataracts are one of the most prevalent causes of visual impairment around the world. Understanding the mechanisms of cataract development and progression is essential to enable early clinical diagnosis and treatment to preserve visual acuity. Reductive chemicals are potential medicines effective on cataract treatment. In this work, we investigated the cataract-induced oxidative damage in the crystalline lens and a kind of reductant, α-lipoic acid (ALA), ability to reduce the damage. We created oxidative environment to investigate the relationship between the progression of oxidative cataract and lenticular biomechanical properties measured by dynamic optical coherence elastography in porcine crystalline lenses ex vivo. The efficacy of ALA to minimize the stiffening of the lens was also quantified. The results showed a significant increase in Young’s modulus of the lens due to the formation of the oxidative cataract. We found a statistically significant difference between Young’s modulus of the lenses stored in phosphate-buffered saline and ALA solution after incubation in H2O2 solution for 3 h (43.0 ± 9.0 kPa versus 20.7 ± 3.5 kPa, respectively). These results show that the lens stiffness increases during oxidative cataract formation, and ALA has the potential to reverse stiffening of the lens caused by oxidative damage.

scholarly journals Age-Related Changes in the Rhesus Macaque Eye

2021 ◽  
Author(s):  
Kira Lin ◽  
Tu Tran ◽  
Soohyun Kim ◽  
Sangwan Park ◽  
Jiajia Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Rhesus Macaque ◽  
Axial Length ◽  
Rhesus Macaques ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Lens Thickness ◽  
Age Related ◽  
Age Related Changes

Purpose: To assess age-related changes in the rhesus macaque eye and evaluate them to corresponding human age-related eye disease. Methods: Data from eye exams and imaging tests including intraocular pressure (IOP), lens thickness, axial length, and retinal optical coherence tomography (OCT) images were evaluated from 142 individuals and statistically analyzed for age-related changes. Quantitative autofluorescence (qAF) was measured as was the presence of macular lesions as related to age. Results: Ages of the 142 rhesus macaques ranged from 0.7 to 29 years (mean=16.4 years, stdev=7.5 years). Anterior segment measurements such as IOP, lens thickness, and axial length were acquired. Advanced retinal imaging in the form of optical coherence tomography and qAF were obtained. Quantitative assessments were made and variations by age groups were analyzed to compare with established age-related changes in human eyes. Quantitative analysis of data revealed age-related increase in intraocular pressure, ocular biometry (lens thickness and axial length), and presence of macular lesions. Age-related changes in thicknesses of retinal layers on OCT were observed and quantified. Age was correlated with increased qAF. Conclusions: The rhesus macaque has age-related ocular changes similar to humans. IOP increases with age while retinal ganglion cell layer thickness decreases. Macular lesions develop in some aged animals. Our findings support the concept that rhesus macaques may be useful for the study of important age-related diseases such as glaucoma, macular diseases, and cone disorders, and for development of therapies for these diseases.

scholarly journals Assessing the biomechanical properties of the porcine crystalline lens as a function of intraocular pressure with optical coherence elastography

2018 ◽  
Vol 9 (12) ◽  
pp. 6455 ◽  
Author(s):  
Chen Wu ◽  
Salavat R. Aglyamov ◽  
Zhaolong Han ◽  
Manmohan Singh ◽  
Chih-Hao Liu ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Crystalline Lens ◽  
Biomechanical Properties ◽  
Optical Coherence

Age-related Changes in Crystalline Lens Tilt and Decentration

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Zhangliang Li ◽  
Zehui Zhu ◽  
Xiuyuan Li ◽  
Ziqi Meng ◽  
Wenyong Qu ◽  
...  
Keyword(s):  
Crystalline Lens ◽  
Age Related ◽  
Age Related Changes

scholarly journals Age-Related Changes to the Three-Dimensional Full Shape of the Isolated Human Crystalline Lens

2020 ◽  
Vol 61 (4) ◽  
pp. 11 ◽  
Author(s):  
Eduardo Martinez-Enriquez ◽  
Alberto de Castro ◽  
Ashik Mohamed ◽  
N. Geetha Sravani ◽  
Marco Ruggeri ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Crystalline Lens ◽  
Age Related ◽  
Age Related Changes

Age-Related Changes in Tear Menisci Imaged by Optical Coherence Tomography

2011 ◽  
Vol 88 (10) ◽  
pp. 1214-1219 ◽  
Author(s):  
Lele Cui ◽  
Meixiao Shen ◽  
Jianhua Wang ◽  
Jun Jiang ◽  
Ming Li ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Age Related ◽  
Age Related Changes

Characterization of biomechanical properties of crystalline lens using Brillouin microscopy and optical coherence elastography

2020 ◽  
Author(s):  
Yogeshwari Ambekar ◽  
Manmohan Singh ◽  
Jitao Zhang ◽  
Achuth Nair ◽  
Salavat R. Aglyamov ◽  
...  
Keyword(s):  
Crystalline Lens ◽  
Biomechanical Properties ◽  
Optical Coherence

Age-Related Changes in Biomechanical Properties of the Thoracic Aorta in Horses

2016 ◽  
Vol 154 (1) ◽  
pp. 92
Author(s):  
V. Saey ◽  
N. Famaey ◽  
M. Smoljkic ◽  
E. Claeys ◽  
G. van Loon ◽  
...  
Keyword(s):  
Thoracic Aorta ◽  
Biomechanical Properties ◽  
Age Related ◽  
Age Related Changes
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