Dynamic diffuse optical tomography for assessing changes of breast tumors during neoadjuvant chemotherapy

2015 ◽  
Author(s):  
Jacqueline E. Gunther ◽  
Emerson Lim ◽  
Hyun Keol Kim ◽  
Mindy Brown ◽  
Susan Refice ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Breast Tumors

scholarly journals Ultrasound-Guided Diffuse Optical Tomography for Predicting and Monitoring Neoadjuvant Chemotherapy of Breast Cancers

2015 ◽  
Vol 38 (1) ◽  
pp. 5-18 ◽  
Author(s):  
Chen Xu ◽  
Hamed Vavadi ◽  
Alex Merkulov ◽  
Hai Li ◽  
Mohsen Erfanzadeh ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Breast Cancers ◽  
Ultrasound Guided

scholarly journals Effects of neoadjuvant chemotherapy on the contralateral non-tumor-bearing breast assessed by diffuse optical tomography

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Mirella L. Altoe ◽  
Kevin Kalinsky ◽  
Alessandro Marone ◽  
Hyun K. Kim ◽  
Hua Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Optical Tomography ◽  
Pathologic Complete Response ◽  
Negative Relationship ◽  
Diffuse Optical Tomography ◽  
Complete Response ◽  
Normal Breast ◽  
Mixed Effect ◽  
Tumor Bearing

Abstract Background The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR). Methods In this retrospective evaluation of 105 patients with stage II–III breast cancer, oxy-hemoglobin (ctO2Hb) from the contralateral non-tumor-bearing breast was collected and analyzed at different time points during NAC. The earliest monitoring imaging time point was after 2–3 weeks receiving taxane. Longitudinal data were analyzed using linear mixed-effects modeling to evaluate the contralateral breast ctO2Hb changes across chemotherapy when corrected for pCR status, age, and BMI. Results Patients who achieved pCR to NAC had an overall decrease of 3.88 μM for ctO2Hb (95% CI, 1.39 to 6.37 μM), p = .004, after 2–3 weeks. On the other hand, non-pCR subjects had a non-significant mean reduction of 0.14 μM (95% CI, − 1.30 to 1.58 μM), p > .05. Mixed-effect model results indicated a statistically significant negative relationship of ctO2Hb levels with BMI and age. Conclusions This study demonstrates that the contralateral normal breast tissue assessed by DOTBIS is modifiable after NAC, with changes associated with pCR after only 2–3 weeks of chemotherapy.

scholarly journals Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography

2009 ◽  
Vol 14 (2) ◽  
pp. 024020 ◽  
Author(s):  
Regine Choe ◽  
Soren D. Konecky ◽  
Alper Corlu ◽  
Kijoon Lee ◽  
Turgut Durduran ◽  
...  
Keyword(s):  
Parallel Plate ◽  
Optical Tomography ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Breast Tumors ◽  
Malignant Breast

scholarly journals Breast Tumor Detection Instrument Through Mammography Based NIR DOT

2010 ◽  
Vol 4 (2) ◽  
Author(s):  
Jun-Yu Chen ◽  
H.-Z. Jiang ◽  
L.-Y. Chen ◽  
Min-Chun Pan ◽  
Ch.-T. Wu ◽  
...  
Keyword(s):  
Near Infrared ◽  
Multimodality Imaging ◽  
Imaging Modality ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Breast Tumors ◽  
Imaging Method ◽  
Channel Switching ◽  
X Ray ◽  
Multiple Channel

X-ray mammography has been used in the early detection of breast tumors for decades. Related techniques to enhance preventive screenings are still demanding. Since the 1990s, near infrared diffuse optical tomography (NIR DOT), a functional medical imaging modality, is being exploited and developed to reconstruct optical-coefficient images of tissues. Much endeavor to improve the spatial resolution and contrast of DOT images has been exerted for clinic applications in the diagnosis of breast tumors. The study aims at the design, implementation, and verification of a mammography based NIR DOT. This multimodality imaging method is able to provide information that neither X-ray nor diffuse optical tomography can give alone. To this end, a device with multiple-channel switching of NIR sources and translational scanning of out-emitted intensity constructed on a commercialized mammography system is being designed and built up. We employ the mammography image as structure information that is used as an initial guess for the image reconstruction of optical properties of tissues. Preliminary numerical trials are performed using heterogeneous phantoms made of high-scattering Intralipid. Promising results are obtained with various spatial resolutions due to partial NIR detected intensity.

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