Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

2015 ◽  
Author(s):  
Shaozhen Song ◽  
Nhan Minh Le ◽  
Ruikang K. Wang ◽  
Zhihong Huang
Keyword(s):  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Phase Array ◽  
Optical Coherence ◽  
Array Transducer ◽  
Phase Array Transducer

scholarly journals Development of optical coherence tomography technique for clinical diagnostics and monitoring

2021 ◽  
Author(s):  
Marjan Razani
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Optical Coherence ◽  
Swept Source ◽  
Tissue Equivalent ◽  
Oct Imaging

This dissertation describes techniques that use Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of such waves to enhance the transport of nanoparticles in tissue equivalent phantoms. In the first study, we explored the potential of measuring shear wave propagation using optical co-herence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, syn-chronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were com-posed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. In the second study, we present a technique to image the enhanced particle displacement generated using an acoustic radiation force (ARF) excitation source. A MEMS-VCSEL swept source Optical Coherence Tomography (SS-OCT) system with a center wavelength of 1310 nm, a bandwidth of 100nm, and an A-scan rate of 100 kHz was used to detect gold nanoparticle displacement. ARF was applied after the nanoparticles diffused into a collagen matrix (of different collagen concen-trations and for a tissue engineered MCF-7 breast cancer cell construct). Differential OCT speckle variance images with and without the ARF were used to estimate the particle dis-placement. The images were used to detect the microscopic enhancement of nanoparticle displacement generated by the ARF. Using this OCT imaging technique, the enhanced transport of particles though a collagen gel after using an ARF excitation was imaged and analysed.

scholarly journals Optical Coherence Tomography Detection of Shear Wave

2021 ◽  
Author(s):  
Marjan Razani
Keyword(s):  
Wave Propagation ◽  
Titanium Dioxide ◽  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Sine Wave ◽  
Acoustic Radiation Force ◽  
Optical Coherence ◽  
Swept Source ◽  
Wave Speeds

In this work, we explored the potential of measuring shear wave propagation using Optical Coherence Elastography (OCE). Shear waves were generated using a 20 MHz piezoelectric transducer transmitting sine-wave bursts of 400 μs, synchronized with the OCT swept source wavelength sweep. The acoustic radiation force was applied to two gelatin phantoms (differing in gelatin concentration by weight, 8% vs 14%, respectively). Differential OCT phase maps, measured with and without the acoustic radiation force, demonstrate microscopic displacement generated by shear wave propagation in these phantoms of different stiffness. The shear wave speeds for the 14% and 8% gelatin-titanium dioxide phantoms were 2.24 0.06 m/s and 1.49 0.05 m/s and also the shear modulus estimated using SW-OCE was 5.3±0.2 kPa and 2.3±0.1 kPa for the 14% and 8% gelatin-titanium dioxide phantoms, respectively. The results demonstrate the feasibility of this technique for measuring the mechanical properties of tissue.

scholarly journals Development of optical coherence tomography technique for clinical diagnostics and monitoring

2021 ◽  
Author(s):  
Marjan Razani
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Artery ◽  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Optical Coherence ◽  
Swept Source ◽  
Tissue Equivalent ◽  
Oct Imaging

This dissertation describes techniques that use Optical Coherence Tomography techniques developed for the detection of shear wave propagation in different phantoms, and the use of such waves to enhance the transport of nanoparticles in tissue equivalent phantoms. In the first study, we explored the potential of measuring shear wave propagation using optical co-herence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, syn-chronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were com-posed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. In the second study, we present a technique to image the enhanced particle displacement generated using an acoustic radiation force (ARF) excitation source. A MEMS-VCSEL swept source Optical Coherence Tomography (SS-OCT) system with a center wavelength of 1310 nm, a bandwidth of 100nm, and an A-scan rate of 100 kHz was used to detect gold nanoparticle displacement. ARF was applied after the nanoparticles diffused into a collagen matrix (of different collagen concen-trations and for a tissue engineered MCF-7 breast cancer cell construct). Differential OCT speckle variance images with and without the ARF were used to estimate the particle dis-placement. The images were used to detect the microscopic enhancement of nanoparticle displacement generated by the ARF. Using this OCT imaging technique, the enhanced transport of particles though a collagen gel after using an ARF excitation was imaged and analysed.

scholarly journals Optical Coherence Tomography Detection of Shear Wave

2021 ◽  
Author(s):  
Marjan Razani
Keyword(s):  
Wave Propagation ◽  
Titanium Dioxide ◽  
Shear Wave ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Sine Wave ◽  
Acoustic Radiation Force ◽  
Optical Coherence ◽  
Swept Source ◽  
Wave Speeds

In this work, we explored the potential of measuring shear wave propagation using Optical Coherence Elastography (OCE). Shear waves were generated using a 20 MHz piezoelectric transducer transmitting sine-wave bursts of 400 μs, synchronized with the OCT swept source wavelength sweep. The acoustic radiation force was applied to two gelatin phantoms (differing in gelatin concentration by weight, 8% vs 14%, respectively). Differential OCT phase maps, measured with and without the acoustic radiation force, demonstrate microscopic displacement generated by shear wave propagation in these phantoms of different stiffness. The shear wave speeds for the 14% and 8% gelatin-titanium dioxide phantoms were 2.24 0.06 m/s and 1.49 0.05 m/s and also the shear modulus estimated using SW-OCE was 5.3±0.2 kPa and 2.3±0.1 kPa for the 14% and 8% gelatin-titanium dioxide phantoms, respectively. The results demonstrate the feasibility of this technique for measuring the mechanical properties of tissue.

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