High-sensitivity explosives detection using dual-excitation-wavelength resonance-Raman detector

2014 ◽  
Author(s):  
Balakishore Yellampalle ◽  
William B. McCormick ◽  
Hai-Shan Wu ◽  
Mikhail Sluch ◽  
Robert Martin ◽  
...  
Keyword(s):  
Resonance Raman ◽  
High Sensitivity ◽  
Explosives Detection ◽  
Excitation Wavelength

Multiple-excitation-wavelength resonance-Raman explosives detection

2011 ◽  
Author(s):  
Balakishore Yellampelle ◽  
Mikhail Sluch ◽  
Sanford Asher ◽  
Brian Lemoff
Keyword(s):  
Resonance Raman ◽  
Explosives Detection ◽  
Excitation Wavelength

Photonic crystals: A platform for label-free and enhanced fluorescence biomolecular and cellular assays

2008 ◽  
Vol 1133 ◽  
Author(s):  
Brian T. Cunningham ◽  
Leo Chan ◽  
Patrick C. Mathias ◽  
Nikhil Ganesh ◽  
Sherine George ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Photonic Crystals ◽  
High Throughput Screening ◽  
High Sensitivity ◽  
Excitation Wavelength ◽  
Label Free ◽  
Crystal Surfaces ◽  
Enhanced Fluorescence ◽  
Preferred Direction ◽  
Label Free Detection

Abstract Photonic crystal surfaces represent a class of resonant optical structures that are capable of supporting high intensity electromagnetic standing waves with near-field and far-field properties that can be exploited for high sensitivity detection of biomolecules and cells. While modulation of the resonant wavelength of a photonic crystal by the dielectric permittivity of adsorbed biomaterials enables label-free detection, the resonance can also be tuned to coincide with the excitation wavelength of common fluorescent tags - including organic molecules and semiconductor quantum dots. Photonic crystals are also capable of efficiently channeling fluorescent emission into a preferred direction for enhanced extraction efficiency. Photonic crystals can be designed to support multiple resonant modes that can perform label free detection, enhanced fluorescence excitation, and enhanced fluorescence extraction simultaneously on the same device. Because photonic crystal surfaces may be inexpensively produced over large surface areas by nanoreplica molding processes, they can be incorporated into disposable labware for applications such as pharmaceutical high throughput screening. In this talk, the optical properties of surface photonic crystals will be reviewed and several applications will be described, including results from screening a 200,000-member chemical compound library for inhibitors of protein-DNA interactions, gene expression microarrays, and high sensitivity of protein biomarkers.

scholarly journals Time-resolved surface-enhanced resonance Raman spectro-electrochemistry of heme proteins

2010 ◽  
Vol 24 (1-2) ◽  
pp. 125-129 ◽  
Author(s):  
Marc Grosserueschkamp ◽  
Christoph Nowak ◽  
Wolfgang Knoll ◽  
Renate L. C. Naumann
Keyword(s):  
Heme Proteins ◽  
High Performance ◽  
Resonance Raman Spectroscopy ◽  
Resonance Raman ◽  
Excitation Wavelength ◽  
Silver Surface ◽  
Rotating Disc ◽  
Measuring Cell ◽  
Surface Enhanced ◽  
Silver Substrate

Heme proteins such as cytochrome c (cc) play a fundamental role in many biological processes. Surface-enhanced resonance Raman spectroscopy (SERRS) combined with electrochemical methods is an ideal tool to study the redox processes of heme proteins. In this context we designed a new measuring cell allowing for simultaneous electrochemical manipulation and high sensitive SERRS measurements of heme proteins. The measuring cell is based on an inverted rotating disc electrode for excitation by using a confocal Raman microscope. Furthermore, we developed a SER(R)S-active silver modified silver substrate for spectro-electrochemical applications. For this purpose silver nanoparticles (AgNPs) were adsorbed on top of a planar silver surface. The substrate was optimized for an excitation wavelength of 413 nm corresponding to the resonance frequency of heme structures. An enhancement factor of 105was achieved. The high performance of the new measuring cell in combination with the new silver substrate was demonstrated using cc as a reference system.

Identification of Metalloporphyrins with High Sensitivity Using Graphene-Enhanced Resonance Raman Scattering

Langmuir ◽  
2014 ◽  
Vol 30 (10) ◽  
pp. 2960-2967 ◽  
Author(s):  
Bo-Hyun Kim ◽  
Daechul Kim ◽  
Sungho Song ◽  
DongHyuk Park ◽  
Il-Suk Kang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Resonance Raman ◽  
High Sensitivity ◽  
Resonance Raman Scattering

Performance comparison of single and dual-excitation-wavelength resonance-Raman explosives detectors

2017 ◽  
Author(s):  
Balakishore Yellampalle ◽  
Robert Martin ◽  
Kenneth Witt ◽  
William McCormick ◽  
Hai-Shan Wu ◽  
...  
Keyword(s):  
Resonance Raman ◽  
Performance Comparison ◽  
Excitation Wavelength

scholarly journals A Review on Surface-Enhanced Raman Scattering

Biosensors ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 57 ◽  
Author(s):  
Pilot ◽  
Signorini ◽  
Durante ◽  
Orian ◽  
Bhamidipati ◽  
...  
Keyword(s):  
Raman Scattering ◽  
High Sensitivity ◽  
Surface Enhanced Raman Scattering ◽  
Fingerprint Recognition ◽  
Excitation Wavelength ◽  
User Friendliness ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
The Cost

Surface-enhanced Raman scattering (SERS) has become a powerful tool in chemical, material and life sciences, owing to its intrinsic features (i.e., fingerprint recognition capabilities and high sensitivity) and to the technological advancements that have lowered the cost of the instruments and improved their sensitivity and user-friendliness. We provide an overview of the most significant aspects of SERS. First, the phenomena at the basis of the SERS amplification are described. Then, the measurement of the enhancement and the key factors that determine it (the materials, the hot spots, and the analyte-surface distance) are discussed. A section is dedicated to the analysis of the relevant factors for the choice of the excitation wavelength in a SERS experiment. Several types of substrates and fabrication methods are illustrated, along with some examples of the coupling of SERS with separation and capturing techniques. Finally, a representative selection of applications in the biomedical field, with direct and indirect protocols, is provided. We intentionally avoided using a highly technical language and, whenever possible, intuitive explanations of the involved phenomena are provided, in order to make this review suitable to scientists with different degrees of specialization in this field.

Self-Absorption in Resonance Raman and Rayleigh Scattering: A Numerical Solution

1988 ◽  
Vol 42 (8) ◽  
pp. 1458-1466 ◽  
Author(s):  
Michael Ludwig ◽  
Sanford A. Asher
Keyword(s):  
Rayleigh Scattering ◽  
Resonance Raman Spectroscopy ◽  
Resonance Raman ◽  
Excitation Wavelength ◽  
Signal Attenuation ◽  
Scattering Geometry ◽  
Capillary Sample ◽  
Spectral Signal ◽  
Spectral Detection ◽  
First Time

We have numerically calculated the parameters necessary to correct Raman intensities for self-absorption for Raman measurements utilizing a 90° scattering geometry and a cylindrical capillary sample cell. We display curves that can be used to extract these parameters for any sample absorbances at the incident laser excitation wavelength and the Raman scattered wavelength. These results make it possible, for the first time, to quantitatively utilize resonance Raman spectroscopy to determine concentrations of analytes. These parameters can also be used to numerically correct resonance Raman excitation profile measurements for self-absorption. These results clearly illustrate the dependence of spectral signal-to-noise ratios and spectral detection limits upon signal attenuation due to self-absorption.

scholarly journals Rapid Raman Spectroscopic Analysis of Stress Induced Degradation of the Pharmaceutical Drug Tetracycline

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1866 ◽  
Author(s):  
Christian Domes ◽  
Timea Frosch ◽  
Juergen Popp ◽  
Torsten Frosch
Keyword(s):  
Raman Spectroscopy ◽  
Resonance Raman Spectroscopy ◽  
Resonance Raman ◽  
Pharmaceutical Products ◽  
Small Sample ◽  
Small Concentration ◽  
Stress Factors ◽  
Excitation Wavelength ◽  
Raman Spectroscopic ◽  
Concentration Changes

Stress factors caused by inadequate storage can induce the unwanted degradation of active compounds in pharmaceutical formulations. Resonance Raman spectroscopy is presented as an analytical tool for rapid monitoring of small concentration changes of tetracycline and the metabolite 4˗epianhydrotetracycline. These degradation processes were experimentally induced by changes in temperature, humidity, and irradiation with visible light over a time period of up to 23 days. The excitation wavelength λexc = 413 nm was proven to provide short acquisition times for the simultaneous Raman spectroscopic detection of the degradation of tetracycline and production of its impurity in small sample volumes. Small concentration changes could be detected (down to 1.4% for tetracycline and 0.3% for 4-epianhydrotetracycline), which shows the potential of resonance Raman spectroscopy for analyzing the decomposition of pharmaceutical products.

POSS-based luminescent porous polymers for carbon dioxide sorption and nitroaromatic explosives detection

RSC Advances ◽  
2014 ◽  
Vol 4 (104) ◽  
pp. 59877-59884 ◽  
Author(s):  
Dengxu Wang ◽  
Liguo Li ◽  
Wenyan Yang ◽  
Yujing Zuo ◽  
Shengyu Feng ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
High Sensitivity ◽  
Explosives Detection ◽  
Porous Polymers ◽  
Nitroaromatic Explosives ◽  
Carbon Dioxide Sorption

Luminescent porous polymers based on octavinylsilsequioxane and triphenylamine units show tunable porosity and luminescence, a moderate uptake of CO2 and high sensitivity for TNT.

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