Detection, modeling and matching of pleural thickenings from CT data towards an early diagnosis of malignant pleural mesothelioma

2014 ◽  
Author(s):  
Kraisorn Chaisaowong ◽  
Thomas Kraus
Keyword(s):  
Early Diagnosis ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Ct Data

scholarly journals Extracellular Vesicles-Based Drug Delivery Systems: A New Challenge and the Exemplum of Malignant Pleural Mesothelioma

2020 ◽  
Vol 21 (15) ◽  
pp. 5432 ◽  
Author(s):  
Stefano Burgio ◽  
Leila Noori ◽  
Antonella Marino Gammazza ◽  
Claudia Campanella ◽  
Mariantonia Logozzi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Early Diagnosis ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Malignant Pleural Mesothelioma ◽  
Cell Communication ◽  
Cell Types ◽  
Delivery Systems ◽  
Pleural Mesothelioma ◽  
Potential Use

Research for the most selective drug delivery to tumors represents a fascinating key target in science. Alongside the artificial delivery systems identified in the last decades (e.g., liposomes), a family of natural extracellular vesicles (EVs) has gained increasing focus for their potential use in delivering anticancer compounds. EVs are released by all cell types to mediate cell-to-cell communication both at the paracrine and the systemic levels, suggesting a role for them as an ideal nano-delivery system. Malignant pleural mesothelioma (MPM) stands out among currently untreatable tumors, also due to the difficulties in achieving an early diagnosis. Thus, early diagnosis and treatment of MPM are both unmet clinical needs. This review looks at indirect and direct evidence that EVs may represent both a new tool for allowing an early diagnosis of MPM and a potential new delivery system for more efficient therapeutic strategies. Since MPM is a relatively rare malignant tumor and preclinical MPM models developed to date are very few and not reliable, this review will report data obtained in other tumor types, suggesting the potential use of EVs in mesothelioma patients as well.

scholarly journals Clues to the Early Diagnosis of Malignant Pleural Mesothelioma -Evaluation of Cytological Features at the Molecular Level-

Haigan ◽  
2012 ◽  
Vol 52 (2) ◽  
pp. 196-200
Author(s):  
Tohru Tsujimura ◽  
Ayuko Sato ◽  
Ikuko Torii ◽  
Toshiaki Kamei ◽  
Seiki Hasegawa ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Malignant Pleural Mesothelioma ◽  
Molecular Level ◽  
Pleural Mesothelioma ◽  
Cytological Features

scholarly journals Three-Dimensional Stereoscopic Volume Rendering of Malignant Pleural Mesothelioma

2012 ◽  
Vol 97 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Nathan M Mollberg ◽  
Nigel M Parsad ◽  
Samuel G Armato ◽  
Janani Vigneswaran ◽  
Hedy L Kindler ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Volume Rendering ◽  
Accurate Determination ◽  
Three Dimensional ◽  
Volumetric Analysis ◽  
Preoperative Imaging ◽  
Multidetector Row Computed Tomography ◽  
Pleural Mesothelioma ◽  
Data Sets ◽  
Ct Data

Abstract Our objective was to investigate the application of three-dimensional (3D) stereoscopic volume rendering with perceptual colorization on preoperative imaging for malignant pleural mesothelioma. At present, we have prospectively enrolled 6 patients being considered for resection of malignant pleural mesothelioma that have undergone a multidetector-row computed tomography (CT) scan of the chest. The CT data sets were volume rendered without preprocessing. The resultant 3D rendering was displayed stereoscopically and used to provide information regarding tumor extent, morphology, and anatomic involvement. To demonstrate this technique, this information was compared with the corresponding two-dimensional CT grayscale axial images from two of these patients. Three-dimensional stereoscopic reconstructions of the CT data sets provided detailed information regarding the local extent of tumor that could be used for preoperative surgical planning. Three-dimensional stereoscopic volume rendering for malignant pleural mesothelioma is a novel approach. Combined with our innovative perceptual colorization algorithm, stereoscopic volumetric analysis potentially allows for the accurate determination of the extent of pleural mesothelioma with results difficult to duplicate using grayscale, multiplanar CT images.

scholarly journals Serum Mesothelin for Diagnosing Malignant Pleural Mesothelioma: An Individual Patient Data Meta-Analysis

2012 ◽  
Vol 30 (13) ◽  
pp. 1541-1549 ◽  
Author(s):  
Kevin Hollevoet ◽  
Johannes B. Reitsma ◽  
Jenette Creaney ◽  
Bogdan D. Grigoriu ◽  
Bruce W. Robinson ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Malignant Pleural Mesothelioma ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Pleural Mesothelioma ◽  
Histologic Subtype

Purpose Mesothelin is currently considered the best available serum biomarker of malignant pleural mesothelioma. To examine the diagnostic accuracy and use of serum mesothelin in early diagnosis, we performed an individual patient data (IPD) meta-analysis. Methods The literature search identified 16 diagnostic studies of serum mesothelin, measured with the Mesomark enzyme-linked immunosorbent assay. IPD of 4,491 individuals were collected, including several control groups and 1,026 patients with malignant pleural mesothelioma. Mesothelin levels were standardized for between-study differences and age, after which the diagnostic accuracy and the factors affecting it were examined with receiver operating characteristic (ROC) regression analysis. Results At a common diagnostic threshold of 2.00 nmol/L, the sensitivities and specificities of mesothelin in the different studies ranged widely from 19% to 68% and 88% to 100%, respectively. This heterogeneity can be explained by differences in study population, because type of control group, mesothelioma stage, and histologic subtype significantly affected the diagnostic accuracy. The use of mesothelin in early diagnosis was evaluated by differentiating 217 patients with stage I or II epithelioid and biphasic mesothelioma from 1,612 symptomatic or high-risk controls. The resulting area under the ROC curve was 0.77 (95% CI, 0.73 to 0.81). At 95% specificity, mesothelin displayed a sensitivity of 32% (95% CI, 26% to 40%). Conclusion In patients suspected of having mesothelioma, a positive blood test for mesothelin at a high-specificity threshold is a strong incentive to urge further diagnostic steps. However, the poor sensitivity of mesothelin clearly limits its added value to early diagnosis and emphasizes the need for further biomarker research.

The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

2021 ◽  
pp. 096032712110173
Author(s):  
Zübeyde Tanrıverdi ◽  
Fatih Meteroglu ◽  
Hande Yüce ◽  
Abdurrahman Şenyiğit ◽  
Mümtaz Işcan ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Early Diagnosis ◽  
Malignant Pleural Mesothelioma ◽  
Asbestos Exposure ◽  
Diagnostic Value ◽  
Control Group ◽  
Pleural Mesothelioma ◽  
Spearman Correlation ◽  
Non Invasive ◽  
Noninvasive Markers

Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group ( p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters ( p > 0.05) in the patient group. All biomarkers were positively correlated with each other ( p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.

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