Label-free optical sensing on hybrid plasmonic-nanobiosilica platforms

2014 ◽  
Author(s):  
Fanghui Ren ◽  
Jeremy Campbell ◽  
Gregory L. Rorrer ◽  
Alan X. Wang
Keyword(s):  
Optical Sensing ◽  
Label Free

scholarly journals Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review

Micromachines ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 72 ◽  
Author(s):  
Da-Quan Yang ◽  
Bing Duan ◽  
Xiao Liu ◽  
Ai-Qiang Wang ◽  
Xiao-Gang Li ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Optical Waveguides ◽  
Optical Sensing ◽  
Early Stage ◽  
Disease Diagnosis ◽  
Label Free ◽  
Quality Factors ◽  
Integrated Sensor ◽  
Early Stage Disease ◽  
Wide Range

The ability to detect nanoscale objects is particular crucial for a wide range of applications, such as environmental protection, early-stage disease diagnosis and drug discovery. Photonic crystal nanobeam cavity (PCNC) sensors have attracted great attention due to high-quality factors and small-mode volumes (Q/V) and good on-chip integrability with optical waveguides/circuits. In this review, we focus on nanoscale optical sensing based on PCNC sensors, including ultrahigh figure of merit (FOM) sensing, single nanoparticle trapping, label-free molecule detection and an integrated sensor array for multiplexed sensing. We believe that the PCNC sensors featuring ultracompact footprint, high monolithic integration capability, fast response and ultrahigh sensitivity sensing ability, etc., will provide a promising platform for further developing lab-on-a-chip devices for biosensing and other functionalities.

scholarly journals Active Delivery of Single DNA Molecules into a Plasmonic Nanopore for Label-Free Optical Sensing

Nano Letters ◽  
2018 ◽  
Vol 18 (12) ◽  
pp. 8003-8010 ◽  
Author(s):  
Xin Shi ◽  
Daniel V. Verschueren ◽  
Cees Dekker
Keyword(s):  
Optical Sensing ◽  
Label Free ◽  
Dna Molecules ◽  
Single Dna Molecules

Graphene oxide-based nanohybrid for label-free optical sensing

2014 ◽  
Author(s):  
Anna Borriello ◽  
Lucia Sansone ◽  
Giovanna De Luca ◽  
Pietro La Manna ◽  
Pellegrino Musto ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Optical Sensing ◽  
Label Free

Nanochemical fabrication of a graphene oxide-based nanohybrid for label-free optical sensing with fiber optics

2014 ◽  
Vol 202 ◽  
pp. 523-526 ◽  
Author(s):  
Lucia Sansone ◽  
Viera Malachovska ◽  
Pietro La Manna ◽  
Pellegrino Musto ◽  
Anna Borriello ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Fiber Optics ◽  
Optical Sensing ◽  
Label Free

scholarly journals Label-free, optical sensing of the supramolecular assembly into fibrils of a ditryptophan–DNA hybrid

2014 ◽  
Vol 50 (52) ◽  
pp. 6863-6865 ◽  
Author(s):  
Nidhi Gour ◽  
Jancy Nixon Abraham ◽  
Mohamed Chami ◽  
Axel Castillo ◽  
Sandeep Verma ◽  
...  
Keyword(s):  
Optical Sensing ◽  
Supramolecular Assembly ◽  
Label Free

Label free optical sensing of the formation of WW–DNA fibrillar structures.

scholarly journals A Label-free Optical Sensing Platform for Beta-glucosidase Activity Using Protein-inorganic Hybrid Nanoflowers

2021 ◽  
Author(s):  
Ziping Liu ◽  
Shasha Liu ◽  
Decai Gao ◽  
Yanan Li ◽  
Ye Tian ◽  
...  
Keyword(s):  
Optical Sensing ◽  
Enzymatic Reaction ◽  
Label Free ◽  
Inorganic Hybrid ◽  
Sensing System ◽  
Amplex Red ◽  
Sensing Platform ◽  
Synthesis Strategy ◽  
Beta Glucosidase

Abstract In this work, a convenient, label-free and dual-signal readout optical sensing platform for the sensitively and selectively determination of beta-glucosidase (β-Glu) activity was reported using protein-inorganic hybrid nanoflowers [BSA-Cu3(PO4)2·3H2O] possessing peroxidase-mimicking activity. The nanoflowers (NFs) were facilely synthesized through a self-assembled synthesis strategy at room temperature. The as-prepared NFs could catalytically convert the colorless and non-fluorescent Amplex Red into colored and highly fluorescent resorufin in the presence of hydrogen peroxide via electron transfer process. β-Glu could hydrolyze cyanogenic glycoside, using amygdalin (Amy) as a model, into cyanide ions (CN-), which can subsequently efficiently suppress the catalytic activity of NFs, accompanied with the fluorescence decrease and the color fading. The concentration of CN- was controlled by β-Glu-triggered enzymatic reaction of Amy. Thus, a sensing system was established for fluorescent and visual determination of β-Glu activity. Under the optimum conditions, the present fluorescent and visual bimodal sensing platform exhibited good sensitivity for β-Glu activity assay with a detection limit of 0.33 U·L-1. The sensing platform was further applied to determinate β-Glu in real samples and satisfactory results were attained. Additionally, the label-free optical sensing system can potentially be a promising candidate for β-Glu inhibitors screening.

scholarly journals Development of a Microfluidic-Based Optical Sensing Device for Label-Free Detection of Circulating Tumor Cells (CTCs) Through Their Lactic Acid Metabolism

Sensors ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 6789-6806 ◽  
Author(s):  
Tzu-Keng Chiu ◽  
Kin-Fong Lei ◽  
Chia-Hsun Hsieh ◽  
Hung-Bo Hsiao ◽  
Hung-Ming Wang ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Acid Metabolism ◽  
Optical Sensing ◽  
Label Free ◽  
Label Free Detection ◽  
Lactic Acid Metabolism

Thermally Carbonized Porous Silicon for Robust Label-Free DNA Optical Sensing

2019 ◽  
Vol 3 (1) ◽  
pp. 622-627 ◽  
Author(s):  
Rabeb Layouni ◽  
Moinul H. Choudhury ◽  
Paul E. Laibinis ◽  
Sharon M. Weiss
Keyword(s):  
Porous Silicon ◽  
Optical Sensing ◽  
Label Free ◽  
Free Dna
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