Investigation of effective system designs for transcranial photoacoustic tomography of the brain

Three cooperative mechanisms required for recovery after brain damage

Scientific Reports ◽

10.1038/s41598-019-50946-y ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

D. Berger ◽

E. Varriale ◽

L. Michiels van Kessenich ◽

H. J. Herrmann ◽

L. de Arcangelis

Keyword(s):

Neural Network ◽

Spontaneous Activity ◽

Brain Damage ◽

Functional Activity ◽

System Size ◽

Limited Extent ◽

Combined Application ◽

Effective System ◽

Recovery Mechanisms ◽

The Brain

Abstract Stroke is one of the main causes of human disabilities. Experimental observations indicate that several mechanisms are activated during the recovery of functional activity after a stroke. Here we unveil how the brain recovers by explaining the role played by three mechanisms: Plastic adaptation, hyperexcitability and synaptogenesis. We consider two different damages in a neural network: A diffuse damage that simply causes the reduction of the effective system size and a localized damage, a stroke, that strongly alters the spontaneous activity of the system. Recovery mechanisms observed experimentally are implemented both separately and in a combined way. Interestingly, each mechanism contributes to the recovery to a limited extent. Only the combined application of all three together is able to recover the spontaneous activity of the undamaged system. This explains why the brain triggers independent mechanisms, whose cooperation is the fundamental ingredient for the system’s recovery.

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Optimizing Photoacoustic Tomography: Lymphatic Drainage from the Brain in Pigmented Mice

10.1007/978-3-030-88163-4_2 ◽

2021 ◽

pp. 13-24

Author(s):

Balal Mian ◽

Vladislav Toronov ◽

Xun Zhou ◽

Yeni H. Yucel

Keyword(s):

Lymphatic Drainage ◽

Photoacoustic Tomography ◽

The Brain

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Photoacoustic Tomography of the Brain

Optical Methods and Instrumentation in Brain Imaging and Therapy ◽

10.1007/978-1-4614-4978-2_6 ◽

2012 ◽

pp. 137-156 ◽

Cited By ~ 2

Author(s):

Jun Xia ◽

Lihong V. Wang

Keyword(s):

Photoacoustic Tomography ◽

The Brain

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Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain

Nature Biotechnology ◽

10.1038/nbt839 ◽

2003 ◽

Vol 21 (7) ◽

pp. 803-806 ◽

Cited By ~ 1076

Author(s):

Xueding Wang ◽

Yongjiang Pang ◽

Geng Ku ◽

Xueyi Xie ◽

George Stoica ◽

...

Keyword(s):

In Vivo Imaging ◽

Photoacoustic Tomography ◽

The Brain

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Making Brittle Technologies Useful

Proceedings of the Human Factors and Ergonomics Society Annual Meeting ◽

10.1177/1541931213601533 ◽

2017 ◽

Vol 61 (1) ◽

pp. 198-201

Author(s):

Michael Rayo ◽

Philip J. Smith ◽

Emilie Roth ◽

Nadine Sarter ◽

Kathleen L. Mosier ◽

...

Keyword(s):

Systems Engineering ◽

Human Performance ◽

Cognitive Systems ◽

Cognitive Tools ◽

Cognitive Systems Engineering ◽

Joint Cognitive Systems ◽

Technological Support ◽

Effective System ◽

Joint Cognitive System ◽

System Designs

Across a wide variety of systems, from aviation and ground transportation to energy and financial systems, there continues to be a move toward introducing more powerful technological support. Research and practice have clearly demonstrated that, for these complex systems, human centered designs are critical, especially when anomalous scenarios arise. As a result, one important focus of research in cognitive systems engineering has dealt with understanding how brittle technologies influence joint cognitive system performance. This panel will address three issues: 1) What do we know about how system design affects human performance when the competence envelope for the incorporated technology is exceeded? 2) What guidance is available for the design of joint cognitive systems so that they are robust or resilient when these competence envelopes are exceeded? 3) What important research questions need to be addressed to further extend our understanding regarding how to design and integrate cognitive tools into the work environment and to translate this understanding into effective system designs.

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