PLGA/PFC particles loaded with gold nanoparticles as dual contrast agents for photoacoustic and ultrasound imaging

2014 ◽  
Author(s):  
Yan J. Wang ◽  
Eric M. Strohm ◽  
Yang Sun ◽  
Chengcheng Niu ◽  
Yuanyi Zheng ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Ultrasound Imaging

scholarly journals Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

Biomaterials ◽  
2016 ◽  
Vol 102 ◽  
pp. 87-97 ◽  
Author(s):  
Rabee Cheheltani ◽  
Rami M. Ezzibdeh ◽  
Peter Chhour ◽  
Kumidini Pulaparthi ◽  
Johoon Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Photoacoustic Imaging

Targeting and ultrasound imaging of microbubble-based contrast agents

1999 ◽  
Vol 8 (3) ◽  
pp. 177-184 ◽  
Author(s):  
Alexander L. Klibanov ◽  
Michael S. Hughes ◽  
Flordeliza S. Villanueva ◽  
Ron J. Jankowski ◽  
William R. Wagner ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging

X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer

2010 ◽  
Vol 21 (24) ◽  
pp. 245104 ◽  
Author(s):  
Chie Kojima ◽  
Yasuhito Umeda ◽  
Mikako Ogawa ◽  
Atsushi Harada ◽  
Yasuhiro Magata ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Seeded Growth ◽  
X Ray ◽  
X Ray Computed

scholarly journals Honey, I shrunk the bubbles: microfluidic vacuum shrinkage of lipid-stabilized microbubbles

2021 ◽  
Author(s):  
Vaskar Gnyawali ◽  
Byeong-Ui Moon ◽  
Jennifer Kieda ◽  
Raffi Karshafian ◽  
Michael C. Kolios ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Scale Up ◽  
Ultrasound Contrast Agents ◽  
Simple Approach ◽  
Vacuum Pressure ◽  
Flow Channels ◽  
Ultrasound Contrast ◽  
Microfluidic Flow ◽  
Microfluidic Technique

We present a microfluidic technique that shrinks lipidstabilized microbubbles from O(100) to O(1) µm in diameter–the size that is desirable in applications as ultrasound contrast agents. We achieve microbubble shrinkage by utilizing vacuum channels that are adjacent to the microfluidic flow channels to extract air from the microbubbles. We tune a single parameter, the vacuum pressure, to accurately control the final microbubble size. Finally, we demonstrate that the resulting O(1) µm diameter microbubbles have similar stability to microfluidics generated microbubbles that are not exposed to vacuum shrinkage. We anticipate that, with additional scale-up, this simple approach to shrink microbubbles generated microfluidically will be desirable in ultrasound imaging and therapeutics applications.

scholarly journals Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

2012 ◽  
Vol 41 (18) ◽  
pp. 5472 ◽  
Author(s):  
M. F. Ferreira ◽  
B. Mousavi ◽  
P. M. Ferreira ◽  
C. I. O. Martins ◽  
L. Helm ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Contrast Agents ◽  
High Relaxivity

scholarly journals Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging

2017 ◽  
Vol 6 ◽  
pp. 26-36 ◽  
Author(s):  
Shengtao Lin ◽  
Anant Shah ◽  
Javier Hernández-Gil ◽  
Antonio Stanziola ◽  
Bethany I. Harriss ◽  
...  
Keyword(s):  
Phase Change ◽  
Contrast Agents ◽  
Ultrasound Imaging

Functional and Molecular Ultrasound Imaging: Concepts and Contrast Agents

2009 ◽  
Vol 16 (5) ◽  
pp. 627-642 ◽  
Author(s):  
F. Kiessling ◽  
J. Huppert ◽  
M. Palmowski
Keyword(s):  
Contrast Agents ◽  
Ultrasound Imaging ◽  
Molecular Ultrasound

Gold Nanoparticle-Optimized Computed Tomography Imaging Combined with Transcranial Magnetic Stimulation on Rehabilitation Training of Children with Cerebral Palsy

2021 ◽  
Vol 13 (9) ◽  
pp. 1674-1684
Author(s):  
Yangfan Zhang ◽  
Yuanyuan Luo ◽  
Xinglei Wu ◽  
Liuqiong Yang ◽  
Dandan Cui ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Transcranial Magnetic Stimulation ◽  
Contrast Agents ◽  
Magnetic Stimulation ◽  
Ct Imaging ◽  
Nude Mouse Model ◽  
Children With Cerebral Palsy ◽  
Movement Function ◽  
Ct Contrast

Traditional computed tomography (CT) contrast agents, such as iodine-containing small molecules (omnipaque), have limitations in some applications. The development of nanotechnology has made it possible to develop CT contrast agents based on this technology. In this study, a large number of surface functional groups of the fifth-generation polyamide-amine dendrimer (P5-NH2) were applied to functionally modify polyethylene glycol (PEG), targeting molecules, or drugs, which were used as the carrier of CT contrast agents. With the help of sodium borohydride (NaBH4), there was a rapid reduction. The fluorescein thiocyanate (FT) and PEG modified with lactobionic acid (PEG-LA) weres connected before gold coating to obtain gold nanoparticles coated with targeted dendrimer (Au(P5-LA)DENPs). In the experiment, the gold nanoparticles were characterized, and the liver cancer nude mouse model was established, so as to analyze the CT imaging performance of the material. Besides, the above was applied in the motor function of children with cerebral palsy, and the improvement effect of CT imaging combined with transcranial magnetic stimulation based on the preparation of nanomaterials on the movement function of children was analyzed and demonstrated with the help of graph theory. The results showed that the average particle size of gold nanoparticles was 1.88 nm. Within the range of 5 °C–50 °C and pH = 4–7, the physical properties of the aqueous solution of this material were stable. What’s more, the cell activity still exceeded 80% when the material concentration reached 2000 nm. The nude mouse model of liver cancer indicated that the CT imaging based on this material enhanced the image contrast effect of the tumor part, and the material had no obvious toxic and side effects. CT imaging based on the preparation of nanomaterials can promote transcranial magnetic stimulation to accelerate the efficiency of brain movement, accelerate the global and local information exchange and integration speed of brain network, thereby improving the movement function of children.

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