7, 12 dimethylbenz(a)anthracene(DMBA)-induced "early" Squamous Cell carcinoma in the Golden Syrian hamster: evaluation of an animal model and comparison with "early" forms of human Squamous Cell car

1994 ◽  
Author(s):  
Snezana Andrejevic-Blant ◽  
Jean-Francois Savary ◽  
Charlotte Fontolliet ◽  
Philippe Monnier
Keyword(s):  
Squamous Cell Carcinoma ◽  
Animal Model ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Syrian Hamster ◽  
Golden Syrian Hamster ◽  
Title 7 ◽  
Early Squamous Cell Carcinoma

scholarly journals DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Diana A. Martínez B. ◽  
Paola Andrea Barato Gómez ◽  
Carlos Arturo Iregui Castro ◽  
Jaiver E. Rosas Pérez
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Syrian Hamster ◽  
Mineral Oil ◽  
Carcinogenic Effect ◽  
Group A ◽  
Immunomodulatory Action ◽  
Group B

Objectives. To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters’ right buccal pouches in group A (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n = 4) were painted with mineral oil only. Two animals were sacrificed every three weeks to obtain histological samples and to evaluate pathological abnormalities. After 12 weeks of exposition and with no macroscopic evidence of neoplasms, dexamethasone DM (1 mg/kg) was administered daily for 7 days to the last two animals in the study. In the second experiment, DM was administered since DMBA exposition, following the same protocol as the first experiment. Results. The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10–12 weeks of exposition. In addition, the frequency of histopathological lesions was higher. Conclusion. Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed.

scholarly journals Photobiomodulation effects on head and neck squamous cell carcinoma (HNSCC) in an orthotopic animal model

2019 ◽  
Vol 28 (6) ◽  
pp. 2721-2727 ◽  
Author(s):  
Andrei Barasch ◽  
Hongyan Li ◽  
Vinagolu K. Rajasekhar ◽  
Judith Raber-Durlacher ◽  
Joel B. Epstein ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Animal Model ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma

Animal model and bioinformatics analyses suggest the TIMP1/MMP9 axis as a potential biomarker in oral squamous cell carcinoma

2020 ◽  
Vol 59 (11) ◽  
pp. 1302-1316
Author(s):  
Guoqiang Xu ◽  
Jianing Wei ◽  
Bing Huangfu ◽  
Jiping Gao ◽  
Xiaotang Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Animal Model ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bioinformatics Analyses ◽  
Potential Biomarker

scholarly journals Clinical characteristics of precancerous lesions and early squamous cell carcinoma in the oral cavity.

1999 ◽  
Vol 11 (4) ◽  
pp. 357-363 ◽  
Author(s):  
Teruo Amagasa ◽  
Eiji Fujii ◽  
Tetsuo Suzuki ◽  
Masashi Yamashiro ◽  
Ichiro Ogura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Characteristics ◽  
Precancerous Lesions ◽  
Early Squamous Cell Carcinoma
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