Polarization-coded coherent anti-Stokes Raman scattering microscopy for nonresonant background suppression

2013 ◽  
Author(s):  
Jian Lin ◽  
Paul Kumar Upputuri ◽  
Gong Li ◽  
Haifeng Wang ◽  
Zhiwei Huang
Keyword(s):  
Raman Scattering ◽  
Background Suppression ◽  
Nonresonant Background ◽  
Anti Stokes

scholarly journals Nonresonant background suppression for coherent anti-Stokes Raman scattering microscopy using a multi-wavelength time-lens source

2016 ◽  
Vol 24 (23) ◽  
pp. 26687 ◽  
Author(s):  
Bo Li ◽  
Kriti Charan ◽  
Ke Wang ◽  
Tomás Rojo ◽  
David Sinefeld ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Background Suppression ◽  
Multi Wavelength ◽  
Nonresonant Background ◽  
Anti Stokes

scholarly journals Surface-enhanced FAST CARS: en route to quantum nano-biophotonics

Nanophotonics ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 523-548 ◽  
Author(s):  
Dmitri V. Voronine ◽  
Zhenrong Zhang ◽  
Alexei V. Sokolov ◽  
Marlan O. Scully
Keyword(s):  
Raman Scattering ◽  
Near Field ◽  
Biological Systems ◽  
Spectroscopic Techniques ◽  
Label Free ◽  
Optical Signals ◽  
Surface Enhanced ◽  
Bio Imaging ◽  
Nonresonant Background ◽  
Anti Stokes

AbstractQuantum nano-biophotonics as the science of nanoscale light-matter interactions in biological systems requires developing new spectroscopic tools for addressing the challenges of detecting and disentangling weak congested optical signals. Nanoscale bio-imaging addresses the challenge of the detection of weak resonant signals from a few target biomolecules in the presence of the nonresonant background from many undesired molecules. In addition, the imaging must be performed rapidly to capture the dynamics of biological processes in living cells and tissues. Label-free non-invasive spectroscopic techniques are required to minimize the external perturbation effects on biological systems. Various approaches were developed to satisfy these requirements by increasing the selectivity and sensitivity of biomolecular detection. Coherent anti-Stokes Raman scattering (CARS) and surface-enhanced Raman scattering (SERS) spectroscopies provide many orders of magnitude enhancement of chemically specific Raman signals. Femtosecond adaptive spectroscopic techniques for CARS (FAST CARS) were developed to suppress the nonresonant background and optimize the efficiency of the coherent optical signals. This perspective focuses on the application of these techniques to nanoscale bio-imaging, discussing their advantages and limitations as well as the promising opportunities and challenges of the combined coherence and surface enhancements in surface-enhanced coherent anti-Stokes Raman scattering (SECARS) and tip-enhanced coherent anti-Stokes Raman scattering (TECARS) and the corresponding surface-enhanced FAST CARS techniques. Laser pulse shaping of near-field excitations plays an important role in achieving these goals and increasing the signal enhancement.

Three‐color coherent anti‐Stokes Raman scattering with optical nonresonant background removal

2019 ◽  
Vol 50 (9) ◽  
pp. 1303-1310 ◽  
Author(s):  
Brad Littleton ◽  
Priyank Shah ◽  
Thomas Kavanagh ◽  
David Richards
Keyword(s):  
Raman Scattering ◽  
Background Removal ◽  
Nonresonant Background ◽  
Anti Stokes
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