FullMonte: a framework for high-performance Monte Carlo simulation of light through turbid media with complex geometry

2013 ◽  
Author(s):  
Jeffrey Cassidy ◽  
Lothar Lilge ◽  
Vaughn Betz
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
High Performance ◽  
Complex Geometry ◽  
Turbid Media

scholarly journals PK/PD Analysis of Marbofloxacin by Monte Carlo Simulation against Mycoplasma agalactiae in Plasma and Milk of Lactating Goats after IV, SC and SC-Long Acting Formulations Administration

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1104
Author(s):  
Emilio Fernández-Varón ◽  
Edgar García-Romero ◽  
Juan M. Serrano-Rodríguez ◽  
Carlos M. Cárceles ◽  
Ana García-Galán ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
High Performance ◽  
Small Ruminants ◽  
Area Under The Curve ◽  
Hplc Method ◽  
Surrogate Markers ◽  
Contagious Agalactia ◽  
Lactating Goats ◽  
Long Acting

Contagious agalactia is a mycoplasmosis affecting small ruminants that have become an important issue in many countries. However, PK/PD studies of antibiotics to treat this problem in lactating goats affected by Mycoplasma (M.) agalactiae, the main CA-causing mycoplasma are almost non-existent. The aims of this study were to evaluate the plasma and milk disposition of marbofloxacin in lactating goats after intravenous (IV), subcutaneous (SC) and subcutaneous poloxamer P407 formulations with and without carboxy-methylcellulose (SC-P407-CMC and SC-P407) administration. Marbofloxacin concentrations were analysed by the High Performance Liquid Chromatography (HPLC) method. Minimum inhibitory concentrations (MIC) of M. agalactiae field isolates from mastitic goat’s milk were used to calculate surrogate markers of efficacy. Terminal half-lives of marbofloxacin after IV, SC, SC-P407 and SC-P407-CMC administration were 7.12, 6.57, 13.92 and 12.19 h in plasma, and the half-lives of elimination of marbofloxacin in milk were 7.22, 7.16, 9.30 and 7.74 h after IV, SC, SC-P407 and SC-P407-CMC administration, respectively. Marbofloxacin penetration from the blood into the milk was extensive, with Area Under the Curve (AUCmilk/AUCplasma) ratios ranged 1.04–1.23, and maximum concentrations (Cmax-milk/Cmax-plasma) ratios ranged 0.72–1.20. The PK/PD surrogate markers of efficacy fAUC24/MIC and the Monte Carlo simulation show that marbofloxacin ratio (fAUC24/MIC > 125) using a 90% of target attainment rate (TAR) need a dose regimen between 8.4 mg/kg (SC) and 11.57 mg/kg (P407CMC) and should be adequate to treat contagious agalactia in lactating goats.

scholarly journals Laser light scattering in turbid media Part II: Spatial and temporal analysis of individual scattering orders via Monte Carlo simulation

2009 ◽  
Vol 17 (16) ◽  
pp. 13792 ◽  
Author(s):  
Edouard Berrocal ◽  
David L. Sedarsky ◽  
Megan E. Paciaroni ◽  
Igor V. Meglinski ◽  
Mark A. Linne
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Light Scattering ◽  
Laser Light ◽  
Temporal Analysis ◽  
Laser Light Scattering ◽  
Turbid Media ◽  
Spatial And Temporal Analysis

Fast and accurate new Monte Carlo simulation for light propagation through turbid media

1993 ◽  
Author(s):  
Eric Tinet ◽  
Laurent Servant ◽  
F. Carmona ◽  
Sigrid Avrillier ◽  
Jean-Pierre Ollivier
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Light Propagation ◽  
Turbid Media

scholarly journals Laser optoacoustic imaging of turbid media: determination of optical properties by comparison with diffusion theory and Monte Carlo simulation

1996 ◽  
Author(s):  
Alexander A. Oraevsky ◽  
Rinat O. Esenaliev ◽  
Frank K. Tittel ◽  
Martin R. Ostermeyer ◽  
Lihong V. Wang ◽  
...  
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Optical Properties ◽  
Diffusion Theory ◽  
Turbid Media ◽  
Optoacoustic Imaging
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