scholarly journals Multicolor probe-based confocal laser endomicroscopy: a new world for in vivo and real-time cellular imaging

2013 ◽  
Author(s):  
Tom Vercauteren ◽  
François Doussoux ◽  
Matthieu Cazaux ◽  
Guillaume Schmid ◽  
Nicolas Linard ◽  
...  
Keyword(s):  
Real Time ◽  
New World ◽  
Cellular Imaging ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser

Real-time in-vivo microscopic imaging of the cervix using confocal laser endomicroscopy

2016 ◽  
Vol 25 (4) ◽  
pp. 335-343 ◽  
Author(s):  
Michel Degueldre ◽  
Jean Vandromme ◽  
Alexander de Wind ◽  
Francesco Feoli
Keyword(s):  
Real Time ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Microscopic Imaging

Highlighting Crypt Necrosis by Using Confocal Laser Endomicroscopy for the In Vivo and Real-Time Diagnosis of GI Graft-Versus-Host Disease

2012 ◽  
Vol 30 (35) ◽  
pp. e368-e369 ◽  
Author(s):  
Gheorghe Hundorfean ◽  
Abbas Agaimy ◽  
Mircea T. Chiriac ◽  
Wolf Rösler ◽  
Andreas Mackensen ◽  
...  
Keyword(s):  
Real Time ◽  
Graft Versus Host Disease ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Host Disease ◽  
Graft Versus Host ◽  
Time Diagnosis

scholarly journals Confocal Laser Endomicroscopy and Optical Coherence Tomography for the Diagnosis of Prostate Cancer: A Needle-Based, In Vivo Feasibility Study Protocol (IDEAL Phase 2A) (Preprint)

2018 ◽  
Author(s):  
Abel Swaan ◽  
Christophe K Mannaerts ◽  
Matthijs J V Scheltema ◽  
Jakko A Nieuwenhuijzen ◽  
C Dilara Savci-Heijink ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Optical Coherence Tomography ◽  
Real Time ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Optical Coherence ◽  
Optical Coherence Tomography Imaging

BACKGROUND Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. OBJECTIVE This study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of in vivo focal imaging with confocal laser endomicroscopy and optical coherence tomography. The second is to identify and define characteristics of prostate cancer and normal prostate tissue in confocal laser endomicroscopy and optical coherence tomography imaging by comparing these images with the corresponding histopathology. METHODS In this prospective, in vivo feasibility study, needle-based confocal laser endomicroscopy and optical coherence tomography imaging will be performed before transperineal template mapping biopsy or radical prostatectomy. First, confocal laser endomicroscopy and optical coherence tomography will be performed in 4 patients (2 for each imaging modality) undergoing transperineal template mapping biopsy to assess the feasibility and safety of confocal laser endomicroscopy and optical coherence tomography. If proven to be safe and feasible, confocal laser endomicroscopy and optical coherence tomography will be performed in 10 patients (5 for each imaging modality) undergoing radical prostatectomy. Confocal laser endomicroscopy and optical coherence tomography images will be analyzed by independent, blinded observers. Confocal laser endomicroscopy– and optical coherence tomography–based qualitative and quantitative characteristics and histopathology will be compared. The study complies with the IDEAL (Idea, Development, Exploration, Assessment, Long-term study) stage 2a recommendations. RESULTS At present, the study is enrolling patients and results and outcomes are expected in 2019. CONCLUSIONS Confocal laser endomicroscopy and optical coherence tomography are promising optical imaging techniques that can visualize and analyze tissue structure, possible tumor grade, and architecture in real time. They can potentially provide real-time, high-resolution microscopic imaging and tissue characteristics of prostate cancer in conjunction with magnetic resonance imaging or transrectal ultrasound fusion-guided biopsy procedures. This study will provide insight into the feasibility and tissue-specific characteristics of confocal laser endomicroscopy and optical coherence tomography for real-time optical analysis of prostate cancer. CLINICALTRIAL ClinicalTrials.gov NCT03253458; https://clinicaltrials.gov/ct2/show/NCT03253458 (Archived by WebCite at http://www.webcitation.org/6z9owM66B) REGISTERED REPORT IDENTIFIER RR1-10.2196/9813

Intraoperative confocal laser endomicroscopy for real-time in vivo tissue characterization during surgical procedures

2018 ◽  
Vol 33 (5) ◽  
pp. 1544-1552 ◽  
Author(s):  
David Fuks ◽  
Angelo Pierangelo ◽  
Pierre Validire ◽  
Marine Lefevre ◽  
Abdelali Benali ◽  
...  
Keyword(s):  
Real Time ◽  
Surgical Procedures ◽  
Tissue Characterization ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser
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