Photodynamic therapy and the treatment of neoplastic diseases of the larynx, oral cavity, pharynx, and tracheobronchial tree

1993 ◽  
Author(s):  
Merrill A. Biel
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cavity ◽  
Tracheobronchial Tree ◽  
Neoplastic Diseases

scholarly journals Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients

2010 ◽  
Vol 268 (2) ◽  
pp. 281-288 ◽  
Author(s):  
Baris Karakullukcu ◽  
Kim van Oudenaarde ◽  
Marcel P. Copper ◽  
W. M. C. Klop ◽  
Robert van Veen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cavity ◽  
Early Stage ◽  
Outcome Analysis

scholarly journals Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies

2012 ◽  
Vol 3 (9) ◽  
pp. 2142 ◽  
Author(s):  
Daniel J. Rohrbach ◽  
Nestor Rigual ◽  
Erin Tracy ◽  
Andrew Kowalczewski ◽  
Kenneth L. Keymel ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cavity ◽  
Therapy Response

scholarly journals Photodynamic Therapy for 101 Early Cancers of the Upper Aerodigestive Tract, the Esophagus, and the Bronchi: A Single-Institution Experience

1999 ◽  
Vol 5 (3) ◽  
pp. 145-154 ◽  
Author(s):  
A. Radu ◽  
P. Grosjean ◽  
Ch. Fontolliet ◽  
G. Wagnieres ◽  
A. Woodtli ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Early Stage ◽  
Red Light ◽  
Green Light ◽  
Tracheobronchial Tree ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Photofrin Ii ◽  
Significant Difference ◽  
Radical Therapy

Cancer, when detected at an early stage, has a very good probability of being eradicated by surgery or radiotherapy. However, less aggressive treatments also tend to provide high rates of cure without the side effects of radical therapy. We report on the results of our clinical experience with photodynamic therapy (PDT) for the treatment of early carcinomas in the upper aerodigestive tract, the esophagus, and the tracheobronchial tree. Sixty-four patients with 101 squamous cell carcinomas were treated with three different photosensitizers: hematoporphyrin derivative (HPD), Photofrin II, and tetra (m-hydroxyphenyl)chlorin (mTHPC). Seventy-seven (76%) tumors showed a complete rsponse with no recurrence after a mean follow-up period of 27 months. There was no significant difference in terms of cure rates among the three dyes. However, mTHPC has a stronger phototoxicity and induces a shorter skin photosensitization than either of the other photosensitizers. There were eight major complications: three esophagotracheal fistulae after illumination with red light in the esophagus, two esophageal stenoses following 360° circumferential irradiation, and three bronchial stenoses. Illumination with the less penetrating green light and the use of a 180° or 240° windowed cylindrical light distributor render the risk of complications in the esophagus essentially impossible, without reducing the efficacy of the treatment. Therefore, PDT may be considered as a safe and effective treatment for early carcinomas of the upper aerodigestive tract, the esophagus, and the tracheobronchial tree.

Illumination devices for uniform delivery of light to the oral cavity for photodynamic therapy

2011 ◽  
Author(s):  
Cristina Canavesi ◽  
William J. Cassarly ◽  
Thomas H. Foster ◽  
Jannick P. Rolland
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cavity

scholarly journals Photodynamic Therapy in Advanced Tracheobronchial Cancers

1999 ◽  
Vol 5 (4) ◽  
pp. 245-251 ◽  
Author(s):  
Tom G. Sutedja
Keyword(s):  
Photodynamic Therapy ◽  
Tracheobronchial Tree ◽  
Local Tumor Control ◽  
Treatment Modalities ◽  
Tumor Control ◽  
Tissue Necrosis ◽  
Endoscopic Techniques ◽  
Lung Cancer Patients ◽  
Secondary Tissue ◽  
Effectiveness Studies

Photodynamic therapy (PDT) has been introduced in the early eighties for treating patients with malignancies in the tracheobronchial tract. After intravenous injection of the photosensitizers, the tumor area in the tracheobronchial tree is illuminated bronchoscopically using a laser fiber to transmit light of a specific wavelength during the procedure. Secondary tissue necrosis ensues, because of the thrombosis of the tumor vasculature leading to late tissue hypoxia. Ample data have shown that PDT is effective to obtain full depth tissue necrosis with relative sparing of the normal tissue. Local tumor control can be achieved. Competitive endoscopic techniques such as lasers and electrocautery are applicable to debulk tumor in a less selective but more immediate manner. Skin photosensitivity is a potential morbidity of PDT, especially in using the first generation photosensitizers. This limits its palliative potential. More selective and more phototoxic sensitizers in combination with the use of portable diode laser, may improve the clinical usefulness of PDT in the management of lung cancer patients. However, cost-effectiveness studies comparing PDT and other local bronchoscopic treatment modalities such as thermal lasers, electrocautery, cryotherapy, brachytherapy, whether or not in addition to external radiotherapy and chemotherapy, should be conducted to define its definite role in the palliative treatment of advanced obstructive bronchial cancers.

Photodynamic therapy of recurrent cancer of oral cavity: an alternative to conventional treatment

1996 ◽  
Author(s):  
Eugeny P. Stranadko ◽  
Oleg K. Skobelkin ◽  
Nikolai A. Markichev ◽  
Michail V. Riabov
Keyword(s):  
Photodynamic Therapy ◽  
Oral Cavity ◽  
Conventional Treatment ◽  
Recurrent Cancer
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