High-specificity chemical detection of explosives by tandem mass spectrometry

1993 ◽  
Author(s):  
William R. Stott ◽  
William R. Davidson ◽  
Richard Sleeman
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
High Specificity ◽  
Chemical Detection ◽  
Tandem Mass ◽  
Detection Of Explosives

scholarly journals Analysis of ethylene glycol in animal feed using liquid chromatography electrospray ionization tandem mass spectrometry

2021 ◽  
Vol 4 (4) ◽  
pp. 292-297
Author(s):  
Hong Ngoc Nguyen Thi ◽  
Thanh Nguyen Ha ◽  
Cao Tien Bui ◽  
Cao Son Tran ◽  
Minh Nhat Dinh ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Ethylene Glycol ◽  
Electrospray Ionization ◽  
Animal Feed ◽  
High Specificity ◽  
Tandem Mass ◽  
Esi Ms ◽  
Ionization Tandem Mass Spectrometry

A determination method of ethylene glycol in animal feed by liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was developed. The analysis was performed with a C18 column (150 mm × 4.6 mm, 3.5 µm), and a gradient mobile phase of 0.1 % formic acid solution and acetonitrile. Ethylene glycol and surrogate standard (propylene glycol) were extracted by water at room temperature, derivatized with benzoyl chloride in alkaline medium, and analyzed by LC-ESI-MS/MS. The method has high specificity and selectivity with a detection limit of 0.1 mg/kg, linearity range of 1 - 20 µg/mL, repeatability of 3.08 - 4.41 %, and recovery of  91.1 - 102.0 %, which meet AOAC requirements. This method has been applied to analyze some marketed animal feed samples.

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