Kinetics of carotenoid distribution in human skin in vivo after exogenous stress: disinfectant and wIRA-induced carotenoid depletion recovers from outside to inside

2011 ◽  
Vol 16 (3) ◽  
pp. 035002 ◽  
Author(s):  
Joachim W. Fluhr ◽  
Peter Caspers ◽  
J. Andre van der Pol ◽  
Heike Richter ◽  
Wolfram Sterry ◽  
...  
Keyword(s):  
Human Skin ◽  
Exogenous Stress ◽  
Kinetics Of

Kinetics of optical clearing of human skin studied in vivo using portable Raman spectroscopy

2020 ◽  
Vol 17 (10) ◽  
pp. 105601
Author(s):  
Qingyu Lin ◽  
Ekaterina N Lazareva ◽  
Vyacheslav I Kochubey ◽  
Yixiang Duan ◽  
Valery V Tuchin
Keyword(s):  
Raman Spectroscopy ◽  
Human Skin ◽  
Optical Clearing ◽  
Portable Raman Spectroscopy ◽  
Kinetics Of ◽  
Portable Raman

Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo

2004 ◽  
Vol 200 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Lynn K. Pershing ◽  
Christopher A. Reilly ◽  
Judy L. Corlett ◽  
Dennis J. Crouch
Keyword(s):  
Human Skin ◽  
Elimination Kinetics ◽  
Kinetics Of ◽  
Uptake And Elimination Kinetics

Effect of pH and inhibitors on beta-amyloid fibril assembly

1996 ◽  
Vol 54 ◽  
pp. 752-753
Author(s):  
Beverly E. Maleeff ◽  
Timothy K. Hart ◽  
Stephen J. Wood ◽  
Ronald Wetzel
Keyword(s):  
Amyloid Fibril ◽  
Peptide Fragment ◽  
Hydrophobic Peptides ◽  
Amyloid Fibril Formation ◽  
Effects Of Ph ◽  
Severity Of The Disease ◽  
Kinetics Of ◽  
The Brain

Alzheimer's disease is characterized post-mortem in part by abnormal extracellular neuritic plaques found in brain tissue. There appears to be a correlation between the severity of Alzheimer's dementia in vivo and the number of plaques found in particular areas of the brain. These plaques are known to be the deposition sites of fibrils of the protein β-amyloid. It is thought that if the assembly of these plaques could be inhibited, the severity of the disease would be decreased. The peptide fragment Aβ, a precursor of the p-amyloid protein, has a 40 amino acid sequence, and has been shown to be toxic to neuronal cells in culture after an aging process of several days. This toxicity corresponds to the kinetics of in vitro amyloid fibril formation. In this study, we report the biochemical and ultrastructural effects of pH and the inhibitory agent hexadecyl-N-methylpiperidinium (HMP) bromide, one of a class of ionic micellar detergents known to be capable of solubilizing hydrophobic peptides, on the in vitro assembly of the peptide fragment Aβ.

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