scholarly journals Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles

2009 ◽  
Vol 14 (3) ◽  
pp. 034008 ◽  
Author(s):  
Chang Soo Kim ◽  
Petra Wilder-Smith ◽  
Yeh-Chan Ahn ◽  
Lih-Huei L. Liaw ◽  
Zhongping Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Optical Coherence Tomography ◽  
Oral Cancer ◽  
Early Stage ◽  
Optical Coherence

scholarly journals Detection of Oral Dysplastic and Early Cancerous Lesions by Polarization-Sensitive Optical Coherence Tomography

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2376
Author(s):  
Ping-Hsien Chen ◽  
Hung-Yi Lee ◽  
Yi-Fen Chen ◽  
Yi-Chen Yeh ◽  
Kuo-Wei Chang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Oral Cancer ◽  
Early Stage ◽  
Optical Coherence ◽  
Predictive Values ◽  
Early Stage Cancer ◽  
Oral Cancers ◽  
Cancerous Lesions ◽  
Oral Malignancy

Detection of oral dysplastic and early-stage cancerous lesions is difficult with the current tools. Half of oral cancers are diagnosed in a late stage. Detection of early stromal change to predict malignant transformation is a new direction in the diagnosis of early-stage oral cancer. The application of new optical tools to image stroma in vivo is under investigation, and polarization-sensitive optical coherence tomography (PS-OCT) is potentially one of those tools. This is a preliminary study to sequentially image oral stromal changes from normal, hyperplasia, and dysplasia to early-stage cancer by PS-OCT in vivo. We used 4-Nitroquinoline-1-oxide drinking water to induce dysplasia and early-stage oral cancer in 19 K14-EGFP-miR-211-GFP transgenic mice. A total of 8 normal, 12 hyperplastic, 11 dysplastic, and 4 early-stage cancerous lesions were enrolled. A new analytic process of PS-OCT imaging was proposed, called an en-face birefringence map. From the birefringence map, the sensitivity, specificity, positive predictive value, and negative predictive values to detect dysplasia and early-stage cancer were 100.00%, 95.00%, 93.75%, and 100.00%, respectively, and the kappa value of these images between two investigators was 0.942. The mean size of malignant lesions detected in this study is 1.66 ± 0.93 mm. This pilot animal study validates the use of PS-OCT to detect small and early-stage oral malignancy with high accuracy and consistency.

scholarly journals Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography

2018 ◽  
Vol 5 (1) ◽  
Author(s):  
Chang Soo Kim ◽  
Dominique Ingato ◽  
Petra Wilder-Smith ◽  
Zhongping Chen ◽  
Young Jik Kwon
Keyword(s):  
Optical Coherence Tomography ◽  
Oral Cancer ◽  
Early Stage ◽  
Gold Nanoclusters ◽  
Optical Coherence

In vivo study of contrasting properties of gold nanoparticles for optical coherence tomography

2007 ◽  
Author(s):  
E. V. Zagaynova ◽  
M. V. Shirmanova ◽  
A. G. Orlova ◽  
I. V. Balalaeva ◽  
M. Y. Kirillin ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Optical Coherence Tomography ◽  
In Vivo Study ◽  
Optical Coherence

scholarly journals Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography

2010 ◽  
Vol 1 (1) ◽  
pp. 106 ◽  
Author(s):  
Chang Soo Kim ◽  
Yeh-Chan Ahn ◽  
Petra Wilder-Smith ◽  
Seajin Oh ◽  
Zhongping Chen ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Contrast Enhanced

scholarly journals Optical Coherence Tomography Angiography of Early Stage 1a Retinal Hemangioblastoma in Von-Hippel-Lindau

2021 ◽  
Vol 8 (3) ◽  
pp. 15-18
Author(s):  
Ananya Goswami ◽  
Abhidnya Surve ◽  
Pradeep Venkatesh
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Early Stage ◽  
Optical Coherence ◽  
Von Hippel Lindau ◽  
Retinal Capillary ◽  
Capillary Plexus ◽  
Retinal Hemangioblastoma ◽  
Retinal Capillaries

Von-Hippel-Lindau (VHL) syndrome is characterized by focal vasoproliferative tumors of retinal capillaries called retinal capillary hemangio-blastomas (RCH). These tumors are initially small and can be easily missed if not looked for carefully. As they grow, these tumors are more demanding to treat and hence the importance of detecting them early and treating them. Herein, we describe and review the optical coherence tomography angiography (OCTA) of the early-stage lesion, which suggested the involvement of superficial and a deeper retinal capillary plexus. In addition, to helping us detect these lesions earlier, OCTA may also help to understand the in vivo changes occurring at an earlier phase.

In vivo study of contrasting properties of gold nanoparticles for optical coherence tomography

2007 ◽  
Author(s):  
E.V. Zagaynova ◽  
M.V. Shirmanova ◽  
A.G. Orlova ◽  
I.V. Balalaeva ◽  
M.Yu. Kirillin ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Optical Coherence Tomography ◽  
In Vivo Study ◽  
Optical Coherence

scholarly journals Early detection of enamel demineralization by optical coherence tomography

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Meng-Tsan Tsai ◽  
Yen-Li Wang ◽  
Ting-Wei Yeh ◽  
Hsiang-Chieh Lee ◽  
Wen-Ju Chen ◽  
...  
Keyword(s):  
Surface Roughness ◽  
Optical Coherence Tomography ◽  
Early Stage ◽  
Scattering Coefficient ◽  
Tooth Surface ◽  
Acidic Environment ◽  
Optical Coherence ◽  
Tooth Demineralization

AbstractEnamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study, a high-resolution optical coherence tomography (OCT) system with the axial and transverse resolutions of 2.0 and 2.7 μm in teeth has been utilized for characterizing the effect of the acidic environment (simulated by phosphoric acid) on the enamel topology. The scattering coefficient and the surface roughness of enamel can be directly derived from the OCT results, enabling a quantitative evaluation of the topology changes with demineralization. The dynamic process induced by the acid application is also recorded and analyzed with OCT, depicting the evolution of the demineralization process on enamel. Notably, the estimated enamel scattering coefficient and surface roughness significantly increase with the application time of acid and the results illustrate that the values of both parameters after demineralization are significantly larger than those obtained before the demineralization, illustrating both parameters could be effective to differentiate the healthy and demineralized teeth and determine the severity. The obtained results unambiguously illustrate that demineralization of the tooth surface can be successfully detected by OCT and further used as an indicator of early-stage cavity formation.

APPLICATION OF DOPPLER OPTICAL COHERENCE TOMOGRAPHY IN RHEOLOGICAL STUDIES: BLOOD FLOW AND VESSELS MECHANICAL PROPERTIES EVALUATION

2009 ◽  
Vol 02 (04) ◽  
pp. 431-440 ◽  
Author(s):  
MARCO BONESI ◽  
ANEURIN J. KENNERLEY ◽  
IGOR MEGLINSKI ◽  
STEPHEN MATCHER
Keyword(s):  
Mechanical Properties ◽  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Early Stage ◽  
Diagnostic Technique ◽  
Feasibility Studies ◽  
Optical Coherence ◽  
Blood Flow Dynamics ◽  
Doppler Optical Coherence Tomography

Doppler Optical Coherence Tomography (DOCT) is a noninvasive optical diagnostic technique, which is well suited for the quantitative mapping of microflow velocity profiles and the analysis of flow-vessel interactions. The noninvasive imaging and quantitative analysis of blood flow in the complex-structured vascular bed is required in many biomedical applications, including those where the determination of mechanical properties of vessels or the knowledge of the mechanic interactions between the flow and the housing medium plays a key role. The change of microvessel wall elasticity could be a potential indicator of cardiovascular disease at the very early stage, whilst monitoring the blood flow dynamics and associated temporal and spatial variations in vessel's wall shear stress could help predicting the possible rupture of atherosclerotic plaques. The results of feasibility studies of application of DOCT for the evaluation of mechanical properties of elastic vessel model are presented. The technique has also been applied for imaging of sub-cranial rat blood flow in vivo.

Absolute Blood Flow Measurement of early Stage Chicken Embryo Heart Using High Speed 4D Optical Coherence Tomography

2012 ◽  
Vol 532-533 ◽  
pp. 243-247
Author(s):  
Zhen He Ma ◽  
Xu Liu ◽  
Qiao Yun Wang ◽  
Zhong Hai He
Keyword(s):  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Heart Development ◽  
Chicken Embryo ◽  
High Speed ◽  
Early Stage ◽  
Optical Coherence ◽  
Stage Embryo ◽  
Embryo Heart

The measurement of blood-plasma absolute velocity distributions with spatial and temporal resolution in vivo is important for research on early stage embryo heart development. We introduce a novel method to measure absolute blood flow velocity based on high speed spectral domain Optical Coherence Tomography (OCT) and applied it to measure velocities on the heart outflow tract (OFT) of a chicken embryo (stage HH18).

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