Colloidal mesoporous silica nanoparticles with protoporphyrin IX encapsulated for photodynamic therapy

2009 ◽  
Vol 14 (1) ◽  
pp. 014012 ◽  
Author(s):  
Jun Qian ◽  
Arash Gharibi ◽  
Sailing He
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protoporphyrin Ix

Mannose-Functionalized Mesoporous Silica Nanoparticles for Efficient Two-Photon Photodynamic Therapy of Solid Tumors

2011 ◽  
Vol 123 (48) ◽  
pp. 11627-11631 ◽  
Author(s):  
Magali Gary-Bobo ◽  
Youssef Mir ◽  
Cédric Rouxel ◽  
David Brevet ◽  
Ilaria Basile ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Solid Tumors ◽  
Mesoporous Silica Nanoparticles ◽  
Two Photon ◽  
Functionalized Mesoporous Silica

Small Mesoporous Silica Nanoparticles as Carriers for Enhanced Photodynamic Therapy

2011 ◽  
Vol 6 (9) ◽  
pp. 2332-2338 ◽  
Author(s):  
Jie Zhu ◽  
Huixiang Wang ◽  
Lei Liao ◽  
Lingzhi Zhao ◽  
Liang Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

Core-Shell-structured Dendritic Mesoporous Silica Nanoparticles for Combined Photodynamic Therapy and Antibody Delivery

2017 ◽  
Vol 12 (13) ◽  
pp. 1465-1469 ◽  
Author(s):  
Prasanna Lakshmi Abbaraju ◽  
Yannan Yang ◽  
Meihua Yu ◽  
Jianye Fu ◽  
Chun Xu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Core Shell ◽  
Antibody Delivery

Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy

2010 ◽  
Vol 402 (1-2) ◽  
pp. 221-230 ◽  
Author(s):  
Ouahiba Hocine ◽  
Magali Gary-Bobo ◽  
David Brevet ◽  
Marie Maynadier ◽  
Simon Fontanel ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

Continuous O2-Evolving MnFe2O4 Nanoparticle-Anchored Mesoporous Silica Nanoparticles for Efficient Photodynamic Therapy in Hypoxic Cancer

2017 ◽  
Vol 139 (32) ◽  
pp. 10992-10995 ◽  
Author(s):  
Jonghoon Kim ◽  
Hye Rim Cho ◽  
Hyejin Jeon ◽  
Dokyoon Kim ◽  
Changyeong Song ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

scholarly journals Hydrophobicity-Tuned Periodic Mesoporous Organo-Silica Nanoparticles for Photodynamic Therapy

2020 ◽  
Vol 21 (7) ◽  
pp. 2586
Author(s):  
Chia-Hui Lin ◽  
Ranjith Kumar Kankala ◽  
Prabhakar Busa ◽  
Chia-Hung Lee
Keyword(s):  
Photodynamic Therapy ◽  
Physicochemical Properties ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Membrane Damage ◽  
Protoporphyrin Ix ◽  
Hybrid Nanocomposites ◽  
Cell Membrane Damage

Since their invention, periodic mesoporous organosilicas (PMOs), an innovative class of materials based on organic as well as inorganic hybrid nanocomposites, have gathered enormous interest owing to their advantageous physicochemical attributes over the pristine mesoporous silica nanoparticles (MSNs). To further increase the interactions with the therapeutic guest species and subsequent compatibility as well as the physicochemical properties of PMOs, we demonstrate the post-hydroxylation of benzene-bridged PMO-based nanoparticles for photodynamic therapy (PDT). Initially, the hydrophobic benzene group in the PMO framework is modified through electrophilic substitution-assisted hydroxylation mediated by Fenton as well as Fenton-like reactions utilizing divalent and trivalent metal salts, respectively. These post-grafted PMOs with tuned hydrophobicity resulted in improved biocompatibility as well as drug loading efficiency through governing the interactions in host–guest chemistry by changing the physicochemical properties of the PMO frameworks. Furthermore, the photosensitizer, protoporphyrin IX (PpIX) molecules, encapsulated in the PMO frameworks showed a significant PDT effect in colon carcinoma (HT-29 cell line) and Gram-negative bacterial strain, Escherichia coli (E. coli). Furthermore, the light-induced cytotoxic properties in vitro are confirmed by various tests, including lactate dehydrogenase (LDH) assay for cell membrane damage and caspase assay for apoptosis determination. Indeed, the delivered PpIX molecules from PMOs generated deadly singlet oxygen species intracellularly under visible light irradiation, resulting in cell death through concomitantly triggered apoptotic caspases. Together, our findings demonstrate that this post-modified PMO design is highly advantageous and can be used as an effective PDT platform.

scholarly journals Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy

2009 ◽  
pp. 1475 ◽  
Author(s):  
David Brevet ◽  
Magali Gary-Bobo ◽  
Laurence Raehm ◽  
Sébastien Richeter ◽  
Ouahiba Hocine ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles
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