Raman microscopy for dynamic molecular imaging of living cells

2008 ◽  
Vol 13 (4) ◽  
pp. 044027 ◽  
Author(s):  
Keisaku Hamada ◽  
Katsumasa Fujita ◽  
Nicholas Isaac Smith ◽  
Minoru Kobayashi ◽  
Yasushi Inouye ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Living Cells ◽  
Raman Microscopy

scholarly journals Innentitelbild: Catalytic Molecular Imaging of MicroRNA in Living Cells by DNA-Programmed Nanoparticle Disassembly (Angew. Chem. 9/2016)

2016 ◽  
Vol 128 (9) ◽  
pp. 3000-3000 ◽  
Author(s):  
Xuewen He ◽  
Tao Zeng ◽  
Zhi Li ◽  
Ganglin Wang ◽  
Nan Ma
Keyword(s):  
Molecular Imaging ◽  
Living Cells

scholarly journals 1N1412 Multifocal plane microscopy for three-dimensional molecular imaging and quantificationin living cells(Bioimaging 1,The 49th Annual Meeting of the Biophysical Society of Japan)

2011 ◽  
Vol 51 (supplement) ◽  
pp. S67
Author(s):  
Ryuta Okada ◽  
Katsuo Ichinomiya ◽  
Yasushi Fujimoto ◽  
Katsuyuki Abe ◽  
Yoshihiro Ue ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Annual Meeting ◽  
Three Dimensional ◽  
Living Cells ◽  
Biophysical Society

Gold nanoshell bioconjugates for molecular imaging in living cells

2005 ◽  
Vol 30 (9) ◽  
pp. 1012 ◽  
Author(s):  
Christopher Loo ◽  
Leon Hirsch ◽  
Min-Ho Lee ◽  
Emmanuel Chang ◽  
Jennifer West ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Living Cells ◽  
Gold Nanoshell

Nanomedicine and Early Cancer Diagnosis: Molecular Imaging using Fluorescence Nanoparticles

2020 ◽  
Vol 20 (30) ◽  
pp. 2737-2761
Author(s):  
Ke-Tao Jin ◽  
Jia-Yu Yao ◽  
Xiao-Jiang Ying ◽  
Yan Lin ◽  
Yun-Fang Chen
Keyword(s):  
Molecular Imaging ◽  
Cancer Diagnosis ◽  
Early Cancer ◽  
Living Cells ◽  
Fluorescent Imaging ◽  
Molecular Probe ◽  
Response Monitoring ◽  
Synthesis Methods ◽  
Diagnosis And Therapy ◽  
Early Cancer Diagnosis

Incorporating nanotechnology into fluorescent imaging and magnetic resonance imaging (MRI) has shown promising potential for accurate diagnosis of cancer at an earlier stage than the conventional imaging modalities. Molecular imaging (MI) aims to quantitatively characterize, visualize, and measure the biological processes or living cells at molecular and genetic levels. MI modalities have been exploited in different applications including noninvasive determination and visualization of diseased tissues, cell trafficking visualization, early detection, treatment response monitoring, and in vivo visualization of living cells. High-affinity molecular probe and imaging modality to detect the probe are the two main requirements of MI. Recent advances in nanotechnology and allied modalities have facilitated the use of nanoparticles (NPs) as MI probes. Within the extensive group of NPs, fluorescent NPs play a prominent role in optical molecular imaging. The fluorescent NPs used in molecular and cellular imaging can be categorized into three main groups including quantum dots (QDs), upconversion, and dyedoped NPs. Fluorescent NPs have great potential in targeted theranostics including cancer imaging, immunoassay- based cells, proteins and bacteria detections, imaging-guided surgery, and therapy. Fluorescent NPs have shown promising potentials for drug and gene delivery, detection of the chromosomal abnormalities, labeling of DNA, and visualizing DNA replication dynamics. Multifunctional NPs have been successfully used in a single theranostic modality integrating diagnosis and therapy. The unique characteristics of multifunctional NPs make them potential theranostic agents that can be utilized concurrently for diagnosis and therapy. This review provides the state of the art of the applications of nanotechnologies in early cancer diagnosis focusing on fluorescent NPs, their synthesis methods, and perspectives in clinical theranostics.

scholarly journals Imaging Small Molecules in Living Cells with a Tiny Tag and Raman Microscopy

2012 ◽  
Vol 52 (1) ◽  
pp. 034-035
Author(s):  
Katsumasa FUJITA ◽  
Mikiko SODEOKA
Keyword(s):  
Small Molecules ◽  
Living Cells ◽  
Raman Microscopy

scholarly journals Label-free detection of anticancer drug paclitaxel in living cells by confocal Raman microscopy

2013 ◽  
Vol 102 (11) ◽  
pp. 113701 ◽  
Author(s):  
H. Salehi ◽  
L. Derely ◽  
A.-G. Vegh ◽  
J.-C. Durand ◽  
C. Gergely ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Living Cells ◽  
Raman Microscopy ◽  
Confocal Raman Microscopy ◽  
Label Free ◽  
Label Free Detection ◽  
Confocal Raman
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