White Monte Carlo for time-resolved photon migration

The Monte Carlo code MCML (Monte Carlo modeling of light transport in multi-layered tissue) has been the gold standard for simulations of light transport in multi-layer tissue, but it is ineffective in the presence of three-dimensional (3D) heterogeneity. New techniques have been attempted to resolve this problem, such as MCLS, which is derived from MCML, and tMCimg, which draws upon image datasets. Nevertheless, these approaches are insufficient because of their low precision or simplistic modeling. We report on the development of a novel model for photon migration in voxelized media (MCVM) with 3D heterogeneity. Voxel crossing detection and refractive-index-unmatched boundaries were considered to improve the precision and eliminate dependence on refractive-index-matched tissue. Using a semi-infinite homogeneous medium, steady-state and time-resolved simulations of MCVM agreed well with MCML, with high precision (~100%) for the total diffuse reflectance and total fractional absorption compared to those of tMCimg (< 70%). Based on a refractive-index-matched heterogeneous skin model, the results of MCVM were found to coincide with those of MCLS. Finally, MCVM was applied to a two-layered sphere with multi-inclusions, which is an example of a 3D heterogeneous media with refractive-index-unmatched boundaries. MCVM provided a reliable model for simulation of photon migration in voxelized 3D heterogeneous media, and it was developed to be a flexible and simple software tool that delivers high-precision results.

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Monte Carlo simulation of transit time dependence of Doppler spectra in dynamic time-resolved tomography

10.1117/12.260834 ◽

1996 ◽

Author(s):

Vladimir G. Kolinko ◽

Alexander V. Priezzhev ◽

Frits F. M. de Mul

Keyword(s):

Monte Carlo Simulation ◽

Monte Carlo ◽

Time Dependence ◽

Transit Time ◽

Time Resolved ◽

Dynamic Time

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Research on the Near-Infrared (NIR) Photon Migration in the Knee

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.760-762.388 ◽

2013 ◽

Vol 760-762 ◽

pp. 388-391

Author(s):

Yan Ping Chen ◽

Xiong Ma ◽

Chun Bin Li ◽

Song Qing Chen

Keyword(s):

Monte Carlo ◽

Muscle Tissue ◽

Layered Structure ◽

Near Infrared ◽

Propagation Model ◽

Osteoarthritis Of The Knee ◽

Photon Migration ◽

Photon Propagation ◽

Non Invasive ◽

Distribution Rule

To study the phenomena of photon migration in the knee joint is very important in the field of non-invasive near-infrared optical early diagnosis of osteoarthritis of the knee (KOA). In this paper, a photon propagation model of the knee layered structure based on Monte Carlo method is proposed. The migration trace and distribution rule of the photons in knee layered structure are simulated by the Monte Carlo modeling. The proportion of photons which collide with bone tissue then migrate out of the muscle tissue and photons directly migrate out of muscle tissue is calculated and analyzed. The conclusion is that the MC method provided in this study is useful to analyze the photon migration in knee layered structure and to place the detector in a suitable position.

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Monte Carlo Modeling of Photon Migration for the Needs of Biomedical Optics and Biophotonics

Advanced Biophotonics - Series in Optics and Optoelectronics ◽

10.1201/b15256-2 ◽

2013 ◽

pp. 1-72 ◽

Cited By ~ 1

Author(s):

Igor Meglinski ◽

Alexander Doronin

Keyword(s):

Monte Carlo ◽

Biomedical Optics ◽

Photon Migration ◽

Monte Carlo Modeling

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