scholarly journals In vivo determination of skin near-infrared optical properties using diffuse optical spectroscopy

2008 ◽  
Vol 13 (1) ◽  
pp. 014016 ◽  
Author(s):  
Sheng-Hao Tseng ◽  
Alexander Grant ◽  
Anthony J. Durkin
Keyword(s):  
Optical Properties ◽  
Optical Spectroscopy ◽  
Near Infrared ◽  
Diffuse Optical Spectroscopy ◽  
Infrared Optical Properties

scholarly journals Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopy

2006 ◽  
Vol 100 (2) ◽  
pp. 615-622 ◽  
Author(s):  
Jangwoen Lee ◽  
Naglaa El-Abaddi ◽  
Andrew Duke ◽  
Albert E. Cerussi ◽  
Matthew Brenner ◽  
...  
Keyword(s):  
Real Time ◽  
Optical Spectroscopy ◽  
Near Infrared ◽  
Ex Vivo ◽  
Rabbit Model ◽  
Nir Spectroscopy ◽  
Blood Chemistry ◽  
Diffuse Optical Spectroscopy ◽  
Methemoglobin Formation

We present noninvasive, quantitative in vivo measurements of methemoglobin formation and reduction in a rabbit model using broadband diffuse optical spectroscopy (DOS). Broadband DOS combines multifrequency frequency-domain photon migration (FDPM) with time-independent near infrared (NIR) spectroscopy to quantitatively measure bulk tissue absorption and scattering spectra between 600 nm and 1,000 nm. Tissue concentrations (denoted by brackets) of methemoglobin ([MetHb]), deoxyhemoglobin ([Hb-R]), and oxyhemoglobin ([HbO2]) were determined from absorption spectra acquired in “real time” during nitrite infusions in nine pathogen-free New Zealand White rabbits. As little as 30 nM [MetHb] changes were detected for levels of [MetHb] that ranged from 0.80 to 5.72 μM, representing 2.2 to 14.9% of the total hemoglobin content (%MetHb). These values agreed well with on-site ex vivo cooximetry data ( r2 = 0.902, P < 0.0001, n = 4). The reduction of MetHb to functional hemoglobins was also carried out with intravenous injections of methylene blue (MB). As little as 10 nM changes in [MB] were detectable at levels of up to 150 nM in tissue. Our results demonstrate, for the first time, the ability of broadband DOS to noninvasively quantify real-time changes in [MetHb] and four additional chromophore concentrations ([Hb-R], [HbO2], [H2O], and [MB]) despite significant overlapping spectral features. These techniques are expected to be useful in evaluating dynamics of drug delivery and therapeutic efficacy in blood chemistry, human, and preclinical animal models.

scholarly journals Special Issue on New Horizons in Time Domain Diffuse Optical Spectroscopy and Imaging

2020 ◽  
Vol 10 (8) ◽  
pp. 2752
Author(s):  
Yoko Hoshi
Keyword(s):  
Infrared Spectroscopy ◽  
Optical Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Time Domain ◽  
Near Infrared ◽  
Special Issue ◽  
Diffuse Optical Spectroscopy ◽  
New Horizons

In 1977, Jöbsis first described the in vivo application of near-infrared spectroscopy (NIRS) [...]

In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy

2005 ◽  
Vol 10 (2) ◽  
pp. 024028 ◽  
Author(s):  
Jun Zhao ◽  
Hai Shu Ding ◽  
Xin Lin Hou ◽  
Cong Le Zhou ◽  
Britton Chance
Keyword(s):  
Optical Properties ◽  
Infrared Spectroscopy ◽  
Frequency Domain ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Infant Brain

Effects of the Menstrual Cycle on the Red and Near-infrared Optical Properties of the Human Breast ¶

2000 ◽  
Vol 72 (3) ◽  
pp. 383-391 ◽  
Author(s):  
Rinaldo Cubeddu ◽  
Cosimo D'Andrea ◽  
Antonio Pifferi ◽  
Paola Taroni ◽  
Alessandro Torricelli ◽  
...  
Keyword(s):  
Optical Properties ◽  
Menstrual Cycle ◽  
Near Infrared ◽  
Human Breast ◽  
Infrared Optical Properties

Near-Infrared Optical Properties and Charge Transport in Expanded Porphyrins

2021 ◽  
Vol MA2021-01 (16) ◽  
pp. 761-761
Author(s):  
Gloria Cardenas-Jiron ◽  
Merlys Borges-Martinez ◽  
Nicolas Montenegro-Pohlhammer ◽  
Yoh Yamamoto ◽  
Tunna Baruah ◽  
...  
Keyword(s):  
Optical Properties ◽  
Charge Transport ◽  
Near Infrared ◽  
Expanded Porphyrins ◽  
Infrared Optical Properties

scholarly journals Multi-layered tissue head phantoms for noninvasive optical diagnostics

2015 ◽  
Vol 08 (03) ◽  
pp. 1541005 ◽  
Author(s):  
M. S. Wróbel ◽  
A. P. Popov ◽  
A. V. Bykov ◽  
M. Kinnunen ◽  
M. Jędrzejewska-Szczerska ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Optical Measurement ◽  
Human Head ◽  
Medical Diagnostics ◽  
Optical Parameters ◽  
Measurement Systems ◽  
Tissue Phantoms ◽  
Optical And Mechanical Properties

Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical properties of phantoms depend on their purpose. Nevertheless, they must accurately simulate specific tissues they are supposed to mimic. Many tissues and organs including head possess a multi-layered structure, with specific optical properties of each layer. However, such a structure is not always addressed in the present-day phantoms. In this paper, we focus on the development of a plain-parallel multi-layered phantom with optical properties (reduced scattering coefficient [Formula: see text] and absorption coefficient μa) corresponding to the human head layers, such as skin, skull, and gray and white matter of the brain tissue. The phantom is intended for use in noninvasive diffuse near-infrared spectroscopy (NIRS) of human brain. Optical parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation method. The results show that polyvinyl chloride-plastisol (PVCP) and zinc oxide ( ZnO ) nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering properties. Good matching was found between optical properties of phantoms and the corresponding values found in the literature.

Transport and near‐infrared optical properties of ErSi2thin films

1992 ◽  
Vol 72 (9) ◽  
pp. 4295-4299 ◽  
Author(s):  
I. Sagnes ◽  
G. Vincent ◽  
P. A. Badoz
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Infrared Optical Properties
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