Approximation of Mie scattering parameters in near-infrared tomography of normal breast tissue in vivo

2005 ◽  
Vol 10 (5) ◽  
pp. 051704 ◽  
Author(s):  
Xin Wang ◽  
Brian W. Pogue ◽  
Shudong Jiang ◽  
Xiaomei Song ◽  
Keith D. Paulsen ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Near Infrared ◽  
Normal Breast Tissue ◽  
Mie Scattering ◽  
Normal Breast ◽  
Scattering Parameters ◽  
Infrared Tomography

In Vivo Imaging of Pressure Effects in Normal Breast Tissue with Quantitative Multi-Spectral Near-Infrared Tomography

2004 ◽  
Author(s):  
Shudong Jiang ◽  
Brian W. Pogue ◽  
Xiaomei Song ◽  
Subhadra Srinivasan ◽  
Keith D. Paulsen ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Breast Tissue ◽  
Near Infrared ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Pressure Effects ◽  
Infrared Tomography

Image reconstruction of effective Mie scattering parameters of breast tissue in vivo with near-infrared tomography

2006 ◽  
Vol 11 (4) ◽  
pp. 041106 ◽  
Author(s):  
Xin Wang ◽  
Brian W. Pogue ◽  
Shudong Jiang ◽  
Hamid Dehghani ◽  
Xiaomei Song ◽  
...  
Keyword(s):  
Image Reconstruction ◽  
Breast Tissue ◽  
Near Infrared ◽  
Mie Scattering ◽  
Scattering Parameters ◽  
Infrared Tomography

scholarly journals Postmenopausal Dense Breasts Maintain Premenopausal Levels of GH and Insulin-like Growth Factor Binding Proteins in Vivo

2020 ◽  
Vol 105 (5) ◽  
pp. 1617-1628 ◽  
Author(s):  
Nina Dabrosin ◽  
Charlotta Dabrosin
Keyword(s):  
Postmenopausal Women ◽  
Breast Density ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Dense Breast ◽  
Breast Cancers ◽  
Dense Breast Tissue ◽  
Dense Breasts

Abstract Context Dense breast tissue is associated with 4 to 6 times higher risk of breast cancer by poorly understood mechanisms. No preventive therapy for this high-risk group is available. After menopause, breast density decreases due to involution of the mammary gland. In dense breast tissue, this process is haltered by undetermined biological actions. Growth hormone (GH) and insulin-like binding proteins (IGFBPs) play major roles in normal mammary gland development, but their roles in maintaining breast density are unknown. Objective To reveal in vivo levels of GH, IGFBPs, and other pro-tumorigenic proteins in the extracellular microenvironment in breast cancer, in normal breast tissue with various breast density in postmenopausal women, and premenopausal breasts. We also sought to determine possible correlations between these determinants. Setting and Design Microdialysis was used to collect extracellular in vivo proteins intratumorally from breast cancers before surgery and from normal human breast tissue from premenopausal women and postmenopausal women with mammographic dense or nondense breasts. Results Estrogen receptor positive breast cancers exhibited increased extracellular GH (P < .01). Dense breasts of postmenopausal women exhibited similar levels of GH as premenopausal breasts and significantly higher levels than in nondense breasts (P < .001). Similar results were found for IGFBP-1, -2, -3, and -7 (P < .01) and for IGFBP-6 (P <.05). Strong positive correlations were revealed between GH and IGFBPs and pro-tumorigenic matrix metalloproteinases, urokinase-type plasminogen activator, Interleukin 6, Interleukin 8, and vascular endothelial growth factor in normal breast tissue. Conclusions GH pathways may be targetable for cancer prevention therapeutics in postmenopausal women with dense breast tissue.

Developments in Quantitative Oxygen-Saturation Imaging of Breast Tissue In Vivo Using Multispectral Near-Infrared Tomography

2007 ◽  
Vol 9 (8) ◽  
pp. 1143-1156 ◽  
Author(s):  
Subhadra Srinivasan ◽  
Brian W. Pogue ◽  
Colin Carpenter ◽  
Shudong Jiang ◽  
Wendy A. Wells ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Breast Tissue ◽  
Near Infrared ◽  
Infrared Tomography

scholarly journals Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography

2016 ◽  
Vol 21 (9) ◽  
pp. 091316 ◽  
Author(s):  
Kelly E. Michaelsen ◽  
Venkataramanan Krishnaswamy ◽  
Linxi Shi ◽  
Srinivasan Vedantham ◽  
Andrew Karellas ◽  
...  
Keyword(s):  
Breast Density ◽  
Breast Tissue ◽  
Near Infrared ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Breast Tomosynthesis ◽  
Infrared Spectral ◽  
Spectral Tomography

scholarly journals Measurement of pressure-displacement kinetics of hemoglobin in normal breast tissue with near-infrared spectral imaging

2009 ◽  
Vol 48 (10) ◽  
pp. D130 ◽  
Author(s):  
Shudong Jiang ◽  
Brian W. Pogue ◽  
Ashley M. Laughney ◽  
Christine A. Kogel ◽  
Keith D. Paulsen
Keyword(s):  
Breast Tissue ◽  
Near Infrared ◽  
Normal Breast Tissue ◽  
Spectral Imaging ◽  
Normal Breast ◽  
Infrared Spectral ◽  
Kinetics Of
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