Atomic force microscopy for nanoscale mechanical property characterization

2020 ◽  
Vol 38 (6) ◽  
pp. 060801
Author(s):  
Gheorghe Stan ◽  
Sean W. King
Keyword(s):  
Mechanical Property ◽  
Atomic Force Microscopy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Property Characterization

Morphology/Mechanical Property Correlations in Multiphase Polyolefin Blends: An Atomic Force Microscopy Study

2004 ◽  
Vol 10 (S02) ◽  
pp. 1084-1085
Author(s):  
Francis M Mirabella
Keyword(s):  
Mechanical Property ◽  
Atomic Force Microscopy ◽  
Microscopy Study ◽  
Atomic Force Microscopy Study ◽  
Force Microscopy ◽  
Polyolefin Blends ◽  
Atomic Force ◽  
Property Correlations

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.

scholarly journals Surface ultrastructure and mechanical property of human chondrocyte revealed by atomic force microscopy

2008 ◽  
Vol 16 (4) ◽  
pp. 480-488 ◽  
Author(s):  
C.-H. Hsieh ◽  
Y.-H. Lin ◽  
S. Lin ◽  
J.-J. Tsai-Wu ◽  
C.H. Herbert Wu ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Atomic Force Microscopy ◽  
Surface Ultrastructure ◽  
Force Microscopy ◽  
Human Chondrocyte ◽  
Atomic Force

scholarly journals NanoScale Quantitative Mechanical Property Mapping Using Peak Force Tapping Atomic Force Microscopy

2010 ◽  
Vol 16 (S2) ◽  
pp. 464-465 ◽  
Author(s):  
SC Minne ◽  
Y Hu ◽  
S Hu ◽  
B Pittenger ◽  
C Su
Keyword(s):  
Mechanical Property ◽  
Atomic Force Microscopy ◽  
Peak Force ◽  
Force Microscopy ◽  
Atomic Force

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.

scholarly journals Mechanical Characterization of Human Corneal Epithelial Cells using Atomic Force Microscopy

2021 ◽  
Author(s):  
Wenyan Yu ◽  
Tong Liu ◽  
Jianqing Mi ◽  
hyock ju Kwon
Keyword(s):  
Mechanical Properties ◽  
Mechanical Property ◽  
Atomic Force Microscopy ◽  
Epithelial Cells ◽  
Corneal Epithelial Cells ◽  
Corneal Epithelial ◽  
Force Microscopy ◽  
Nano Indentation ◽  
Atomic Force ◽  
Human Corneal Epithelial Cells

Abstract Background Cell mechanics focuses on the mechanical properties of the cells and how they affect biological behaviors of cells. Mechanical property change of cells can reflect specific diseases and conditions. Therefore, detecting the changes in cell mechanical properties can potentially be associated with diagnosis and treatment of diseases.MethodsMechanical properties of living and dead human corneal epithelial cells (HCECs) were investigated with nano-indentation method using atomic force microscopy (AFM). Sneddon model was adopted to analyze the contacts between pyramidal AFM tip and soft materials. Polyacrylamide (PAAm) substrates with different stiffness were fabricated and human corneal epithelial cells (HCECs) were cultured on them. By applying nano-indentation to HCECs, we examined the distribution of elasticity across cells, and studied the differences between living and dead cells. Findings The central part of a cell, closer to nucleus, was more compliant than the outer regions, toward the surface of the cell’s lipid bilayer. Also, HCECs became stiffer as the stiffness of the substrate increased. Moreover, it was found that dead cells have much higher elastic moduli and exhibited elastic behavior, while living cells showed highly viscoelastic behavior.InterpretationAFM probing is an effective tool for characterizing cell mechanical behavior. More indentation results should be made in further studies to form statistical model of elasticity distribution for HCECs. This study can be extended to investigate the mechanical behaviors of benign and malignant cells or drug interactions on cells, which can establish more probable mechanical property–disease connections.

Atomic Force Microscopy of Mechanical Property of Natural Rubber

2005 ◽  
Vol 44 (7B) ◽  
pp. 5393-5396 ◽  
Author(s):  
Hiroyuki Watabe ◽  
Motonori Komura ◽  
Ken Nakajima ◽  
Toshio Nishi
Keyword(s):  
Mechanical Property ◽  
Atomic Force Microscopy ◽  
Natural Rubber ◽  
Force Microscopy ◽  
Atomic Force
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