scholarly journals Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery

2018 ◽  
Vol 13 (6) ◽  
pp. 06D407 ◽  
Author(s):  
Sean Harvey ◽  
David Yuen Wah Ng ◽  
Jolanta Szelwicka ◽  
Lisa Hueske ◽  
Lothar Veith ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Cellular Delivery ◽  
Facile Synthesis

Facile synthesis and self-assembly behaviour of pH-responsive degradable polyacetal dendrimers

2016 ◽  
Vol 7 (40) ◽  
pp. 6154-6158 ◽  
Author(s):  
Da Huang ◽  
Fei Yang ◽  
Xing Wang ◽  
Hong Shen ◽  
Yezi You ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Self Assembly ◽  
Ph Responsive ◽  
Facile Synthesis

Well-defined POSS hybrid polyacetal dendrimers functionalized with terminal polyethylene glycol and zwitterion could assemble into pH-responsive degradable micelles and nanofibers.

Evaluation of in situ gelling chitosan-PEG copolymer for use in the spinal cord

2018 ◽  
Vol 33 (3) ◽  
pp. 435-446 ◽  
Author(s):  
Ashley E Mohrman ◽  
Mahmoud Farrag ◽  
Rachel K Grimm ◽  
Nic D Leipzig
Keyword(s):  
Spinal Cord ◽  
Polyethylene Glycol ◽  
Spinal Cord Injuries ◽  
Similar Response ◽  
Cellular Delivery ◽  
Thiolated Chitosan ◽  
Cord Injury ◽  
In Situ Gelling

The goal of the present work was to characterize a hydrogel material for localized spinal cord delivery. To address spinal cord injuries, an injectable in situ gelling system was tested utilizing a simple, effective, and rapid cross-linking method via Michael addition. Thiolated chitosan material and maleimide-terminated polyethylene glycol material were mixed to form a hydrogel and evaluated in vitro and in vivo. Three distinct thiolated chitosan precursors were made by varying reaction conditions; a modification of chitosan with Traut’s reagent (2-iminothiolane) displayed the most attractive hydrogel properties once mixed with polyethylene glycol. The final hydrogel chosen for animal testing had a swelling ratio (Q) of 57.5 ± 3.4 and elastic modulus of 378 ± 72 Pa. After confirming low cellular toxicity in vitro, the hydrogel was injected into the spinal cord of rats for 1 and 2 weeks to assess host reaction. The rats displayed no overt functional deficits due to injection following initial surgical recovery and throughout the 2-week period after for both the saline-injected sham group and hydrogel-injected group. The saline and hydrogel-injected animals both showed a similar response from ED1+ microglia and GFAP overexpression. No significant differences were found between saline-injected and hydrogel-injected groups for any of the measures studied, but there was a trend toward decreased affected area size from 1 to 2 weeks in both groups. Access to the central nervous system is limited by the blood–brain barrier for noninvasive therapies; further development of the current system for localized drug or cellular delivery has the potential to shape treatments of spinal cord injury.

A facile synthesis method of nickel nanotubes assisted by polyethylene glycol

2009 ◽  
Vol 50 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Feifei Tao ◽  
Cuiling Gao ◽  
Zheng Xu ◽  
Ziling Xue
Keyword(s):  
Polyethylene Glycol ◽  
Synthesis Method ◽  
Facile Synthesis

Facile synthesis of Fe-baicalein nanoparticles for photothermal/chemodynamic therapy with accelerated Fe(III)/Fe(II) conversion

2021 ◽  
Author(s):  
Zhendong Liu ◽  
Chunling Hu ◽  
Sainan Liu ◽  
Lihan Cai ◽  
Ying Zhou ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Conversion Efficiency ◽  
Chemical Method ◽  
Room Temperature ◽  
Antitumor Efficacy ◽  
Wet Chemical Method ◽  
Facile Synthesis ◽  
Photothermal Conversion ◽  
Wet Chemical

Fe(II)-baicalein-polyethylene glycol (Fe-BaP) nanoparticles were synthesized by a room temperature wet chemical method via coordination between Fe(II) and baicalein. Fe-BaP possessed high photothermal conversion efficiency (η=45.6%) and excellent antitumor efficacy...

scholarly journals Dense hydroxyl polyethylene glycol dendrimer targets activated glia in multiple CNS disorders

2020 ◽  
Vol 6 (4) ◽  
pp. eaay8514 ◽  
Author(s):  
Anjali Sharma ◽  
Rishi Sharma ◽  
Zhi Zhang ◽  
Kevin Liaw ◽  
Siva P. Kambhampati ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Surface Density ◽  
Age Related Macular Degeneration ◽  
Cns Injury ◽  
Facile Synthesis ◽  
Cns Disorders ◽  
Age Related ◽  
Therapeutic Outcomes ◽  
Anti Oxidant

Poor transport of neuropharmaceutics through central nervous system (CNS) barriers limits the development of effective treatments for CNS disorders. We present the facile synthesis of a novel neuroinflammation-targeting polyethylene glycol–based dendrimer (PEGOL-60) using an efficient click chemistry approach. PEGOL-60 reduces synthetic burden by achieving high hydroxyl surface density at low generation, which plays a key role in brain penetration and glia targeting of dendrimers in CNS disorders. Systemically administered PEGOL-60 crosses impaired CNS barriers and specifically targets activated microglia/macrophages at the injured site in diverse animal models for cerebral palsy, glioblastoma, and age-related macular degeneration, demonstrating its potential to overcome impaired blood-brain, blood-tumor-brain, and blood-retinal barriers and target key cells in the CNS. PEGOL-60 also exhibits powerful intrinsic anti-oxidant and anti-inflammatory effects in inflamed microglia in vitro. Therefore, PEGOL-60 is an effective vehicle to specifically deliver therapies to sites of CNS injury for enhanced therapeutic outcomes in a range of neuroinflammatory diseases.

Facile synthesis and chiral recognition of block and star copolymers containing stereoregular helical poly(phenyl isocyanide) and polyethylene glycol blocks

2017 ◽  
Vol 8 (14) ◽  
pp. 2152-2163 ◽  
Author(s):  
Na Liu ◽  
Cui-Hong Ma ◽  
Rui-Wen Sun ◽  
Jian Huang ◽  
Chonglong Li ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Chiral Recognition ◽  
Facile Synthesis ◽  
Star Copolymers

A new Pd(ii) initiator bearing an alkyne headgroup was designed and synthesized.

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