scholarly journals Role of RhoA/Rho kinase signaling pathway in microgroove induced stem cell myogenic differentiation

2015 ◽  
Vol 10 (2) ◽  
pp. 021003 ◽  
Author(s):  
Huaqiong Li ◽  
Feng Wen ◽  
Xincai Wang ◽  
Lay Poh Tan
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Myogenic Differentiation ◽  
Rho Kinase ◽  
Kinase Signaling ◽  
Kinase Signaling Pathway

scholarly journals Angiotensin II Silencing Alleviates Erectile Dysfunction Through Down-Regulating the Rhoa/Rho Kinase Signaling Pathway in Rats with Diabetes Mellitus

2018 ◽  
Vol 45 (1) ◽  
pp. 419-427 ◽  
Author(s):  
Ying Zhang ◽  
Linpei Jia ◽  
Ying Zhang ◽  
Wei Ji ◽  
Hai Li
Keyword(s):  
Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Signaling Pathway ◽  
Corpus Cavernosum ◽  
Rho Kinase ◽  
Control Group ◽  
Kinase Signaling ◽  
Sprague Dawley ◽  
Kinase Signaling Pathway

Background/Aims: We aim to explore the role of angiotensin (Ang)II and the RhoA/Rho kinase signaling pathway in the pathogenesis of erectile dysfunction in diabetes mellitus (DM). Methods: Male Sprague-Dawley (SD) rats were used for experiments and short hairpin RNA (shRNA) was used to silence the AngII gene. The erectile function of rats was observed and intracavernous pressure and mean arterial pressure (ICP/MAP) were measured after electrical stimulation. Relaxation and contraction of smooth muscle in the corpus cavernosum were tested. Western blotting and quantitative RT-PCR were applied to measure the expressions of RhoA, Rho-associated kinase (ROCK)1 and ROCK2. Radioimmunoassay was applied to detect the levels of AngII. Results: Rats in the control group had the most erectile times, followed by AngII-silenced rats with DMED and rats with DMED. Rats with DMED had worse ICP and MAP than AngII-silenced rats. The contraction ability was markedly improved and relaxation ability was decreased in AngII-silenced rats with DMED as compared with rats with DMED. The levels of AngII were significantly increased in DMED rats while significantly decreased after AngII silencing. The mRNA and proteins of RhoA and ROCK2 were expressed in a similar way. Conclusion: AngII silencing improves erectile dysfunction via down-regulating the RhoA/Rho kinase signaling pathway.

Role of the p38 MAP-Kinase Signaling Pathway for Cx32 and Claudin-1 in the Rat Liver

2003 ◽  
Vol 10 (4-6) ◽  
pp. 437-443 ◽  
Author(s):  
Takashi Kojima ◽  
Toshinobu Yamamoto ◽  
Masaki Murata ◽  
Mengdong Lan ◽  
Ken-ichi Takano ◽  
...  
Keyword(s):  
Map Kinase ◽  
Signaling Pathway ◽  
Rat Liver ◽  
P38 Map Kinase ◽  
Kinase Signaling ◽  
Map Kinase Signaling ◽  
Kinase Signaling Pathway ◽  
Map Kinase Signaling Pathway

Distinct functions of erythropoietin and stem cell factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors

Cytokine ◽  
2013 ◽  
Vol 61 (1) ◽  
pp. 329-335 ◽  
Author(s):  
Renaud Geslain ◽  
Shahab Uddin ◽  
Hui Liu ◽  
Hongmei Jiang ◽  
Koen van Besien ◽  
...  
Keyword(s):  
Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Factor ◽  
Kinase Signaling ◽  
Erythroid Progenitors ◽  
Mtor Kinase ◽  
Kinase Signaling Pathway
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