scholarly journals Anterior Cingulate-induced Inhibition of Activities of Descending Periaqueductal Gray Matter Neurons in Rats

PAIN RESEARCH ◽  
1991 ◽  
Vol 7 (2) ◽  
pp. 71-79 ◽  
Author(s):  
Kazuo Toda
Keyword(s):  
Gray Matter ◽  
Periaqueductal Gray ◽  
Anterior Cingulate ◽  
Periaqueductal Gray Matter

scholarly journals The Recovery of Cognitive and Affective Deficiencies Linked with Chronic Osteoarthritis Pain and Implicated Pathways by Slow-Releasing Hydrogen Sulfide Treatment

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1632
Author(s):  
Gerard Batallé ◽  
Xue Bai ◽  
Enric Pouso-Vázquez ◽  
Gerad Roch ◽  
Laura Rodríguez ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Grip Strength ◽  
Gray Matter ◽  
Periaqueductal Gray ◽  
Anterior Cingulate ◽  
Diallyl Disulfide ◽  
Infralimbic Cortex ◽  
Periaqueductal Gray Matter ◽  
Osteoarthritis Pain ◽  
Osteoarthritic Pain

Chronic osteoarthritis pain is accompanied by several comorbidities whose treatment has not been completely resolved. The anti-inflammatory, analgesic, and antidepressant effects of slow-releasing hydrogen sulfide (H2S) donors during osteoarthritic pain have been shown, but their actions in the accompanying memory impairment and anxious-like behaviors have not yet been demonstrated. Using female mice with chronic osteoarthritic pain, the effects of natural, diallyl disulfide (DADS) or synthetic, morpholin-4-ium 4-methoxyphenyl(morpholino) phosphinodithioate dichloromethane complex (GYY4137) slow-releasing H2S donors, on associated cognitive and grip strength deficits and anxiodepressive-like behaviors, were assessed. Their effects on specific brain areas implicated in the modulation of pain and emotional responses were also determined. Results demonstrated an improvement in memory and grip strength deficits, as well as in the anxious-like behaviors associated with chronic pain in GYY4137 and/or DADS treated mice. The painkiller and antidepressant properties of both treatments were also established. Treatment with DADS and/or GYY4137 inhibited: oxidative stress in the amygdala; phosphoinositide 3-kinase overexpression in the amygdala, periaqueductal gray matter, and anterior cingulate cortex; protein kinase B activation in the amygdala and infralimbic cortex; up-regulation of inducible nitric oxide synthase in the amygdala, periaqueductal gray matter and infralimbic cortex and apoptotic responses in the amygdala. These results might explain the recovery of memory and grip strength and the inhibition of allodynia and associated anxiodepressive-like behaviors by these treatments. In conclusion, this study revealed new properties of slow-releasing H2S donors in cognitive impairment and affective disorders linked with chronic osteoarthritis pain and their effects on the central nervous system.

Anxiogenic-like effect of glycine and d-serine microinjected into dorsal periaqueductal gray matter of rats

1995 ◽  
Vol 189 (2) ◽  
pp. 93-96 ◽  
Author(s):  
M.L. Schmitt ◽  
W. Coelho ◽  
A.S. Lopes-de-Souza ◽  
F.S. Guimarães ◽  
A.P. Carobrez
Keyword(s):  
Gray Matter ◽  
Periaqueductal Gray ◽  
Periaqueductal Gray Matter ◽  
Dorsal Periaqueductal Gray
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