scholarly journals Noninvasive quantitative estimation of hepatic steatosis by ultrasound: a comparison of the hepato-renal index and ultrasound attenuation index.

2016 ◽  
Vol 18 (4) ◽  
pp. 431 ◽  
Author(s):  
Heon-Ju Kwon ◽  
Kyoung Won Kim ◽  
Jin-Hee Jung ◽  
Sang Hyun Choi ◽  
Woo Kyoung Jeong ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Interobserver Agreement ◽  
Quantitative Estimation ◽  
Statistical Significance ◽  
Characteristic Curve ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Ultrasound Attenuation ◽  
Attenuation Index ◽  
The Difference

Aims: To compare the accuracy of the ultrasound attenuation index (USAI) and hepato-renal index (HRI) for the diagnosis of hepatic steatosis (HS). Material and methods: Two hundred and twenty-four potential living hepatic donors underwent US and subsequent US-guided liver biopsy. The USAI was calculated from US images with an 8 MHz transducer and HRI was measured on sagittal images with a clear visualization of both the liver and kidney. Using histological degrees of HS as the reference standard, we compared the performance of USAI and HRI for diagnosing HS ≥ 5% and ≥ 30% by receiver operating characteristic curve analysis. The interobserver agreement was evaluated by using intraclass correlation coefficients (ICCs) or Bland–Altman statistics. Results: Histologic degree of HS was 0–70% (median, 5%). HRI showed a tendency towards higher accuracy than USAI for diagnosing HS ≥ 5% (the area under the ROC curve, 0.856 vs. 0.820; p= 0.279) and ≥ 30% (0.937 vs. 0.909; p = 0.378) without statistical significance. There was an excellent interobserver agreement for both USAI and HRI (ICC = 0.931 and 0.973, respectively). According to the Bland–Altman method, the 95% limits of difference between two readers for HS were −8.5% to 6.6% by USAI and −4.8% to 6.2% by HRI. Most patients would have the difference of calculated HS by USAI (74.0%) and HRI (96.0%) from different operators within a range of ±5%. Conclusions: Although statistically insignificant, HRI was superior to USAI for the diagnosis and quantitative estimation of HS in terms of diagnostic performance, including accuracy and reproducibility.

Value of Ultrasound Attenuation Index in Noninvasive Quantitative Estimation of Hepatic Steatosis

2013 ◽  
Vol 39 (5) ◽  
pp. S80-S81 ◽  
Author(s):  
K.W. Kim ◽  
H.J. Kwon ◽  
S.J. Lee ◽  
S.Y. Kim ◽  
J.S. Lee ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Quantitative Estimation ◽  
Ultrasound Attenuation ◽  
Attenuation Index

scholarly journals Reproducibility and reliability of three-dimensional soft tissue landmark identification using three-dimensional stereophotogrammetry

2016 ◽  
Vol 86 (6) ◽  
pp. 1004-1009 ◽  
Author(s):  
Asli Baysal ◽  
Ahmet Oguz Sahan ◽  
Mehmet Ali Ozturk ◽  
Tancan Uysal
Keyword(s):  
Soft Tissue ◽  
Statistical Significance ◽  
Intraclass Correlation ◽  
Three Dimensional ◽  
Correlation Coefficients ◽  
Intraclass Correlation Coefficients ◽  
Paired Samples ◽  
Landmark Identification ◽  
The Difference ◽  
Intraexaminer Reliability

ABSTRACT Objective: To evaluate the intraexaminer repeatability and interexaminer reproducibility of soft tissue landmarks on three-dimensional (3-D) stereophogrammetric images. Materials and Methods: Thirty-four stereophotogrammetric images were taken and 19 soft tissue points were identified. The images were obtained using the 3-DMD Face (3-DMD TM Ltd, Atlanta, Ga) system. Two examiners marked 34 images manually with a mouse-driven cursor 4 weeks apart. Intraexaminer marking differences were calculated and classified as <0.5 mm, 0.5–1 mm, and >1 mm. Intraclass correlation coefficients were calculated for intraexaminer reliability. A paired-samples t-test was used to evaluate the difference between the examiners. Interexaminer reproducibility was evaluated by kappa analysis. Statistical significance was set at P < .05. Results: Only one landmark (labiale superior) had an intraexaminer marking difference less than 0.5 mm. Existing landmarks had an intraexaminer difference less than 1 mm, but higher than 0.5 mm. The intraclass correlation coefficients (ICCs) indicated good intraexaminer repeatability for both observers. The ICC range for examiners 1 and 2 was 0.986–1.000 and 0.990–1.000, respectively. Kappa scores showed good interexaminer agreement, especially on the z-axis. Conclusions: Except labiale superior, the soft tissue landmarks used in this study were shown to have moderate reproducibility, but the difference between the landmarks was less than 1 mm, and they had clinically acceptable reproducibility.

Value of the Ultrasound Attenuation Index for Noninvasive Quantitative Estimation of Hepatic Steatosis

2013 ◽  
Vol 32 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Heon-Ju Kwon ◽  
Kyoung Won Kim ◽  
So Jung Lee ◽  
So Yeon Kim ◽  
Jong Seok Lee ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Quantitative Estimation ◽  
Ultrasound Attenuation ◽  
Attenuation Index

scholarly journals Assessment of reliability and validity of the 5-scale grading system of the point-of-care immunoassay for tear matrix metalloproteinase-9

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Minjeong Kim ◽  
Ja Young Oh ◽  
Seon Ha Bae ◽  
Seung Hyeun Lee ◽  
Won Jun Lee ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Calibration Curve ◽  
Point Of Care ◽  
Interobserver Reliability ◽  
Intraclass Correlation ◽  
Reliability And Validity ◽  
Correlation Coefficients ◽  
Grading System ◽  
Intraclass Correlation Coefficients ◽  
The Difference

AbstractWe evaluated the reliability and validity of the 5-scale grading system to interpret the point-of-care immunoassay for tear matrix metalloproteinase (MMP)-9. Six observers graded red bands of photographs of the readout window in MMP-9 immunoassay kit (InflammaDry) two times with 2-week interval based on the 5-scale grading system (i.e. grade 0–4). Interobserver and intraobserver reliability were evaluated using intraclass correlation coefficients. The interobserver agreements were analyzed according to the severity of tear MMP-9 expression. To validate the system, a concentration calibration curve was made using MMP-9 solutions with reference concentrations, then the distribution of MMP-9 concentrations was analyzed according to the 5-scale grading system. Both intraobserver and interobserver reliability was excellent. The readout grades were significantly correlated with the quantified colorimetric densities. The interobserver variance of readout grades had no correlation with the severity of the measured densities. The band density continued to increase up to a maximal concentration (i.e. 5000 ng/mL) according to the calibration curve. The difference of grades reflected the change of MMP-9 concentrations sensitively, especially between grade 2 and 4. Together, our data indicate that the subjective 5-scale grading system in the point-of-care MMP-9 immunoassay is an easy and reliable method with acceptable accuracy.

scholarly journals Comparison of 1-Repetition-Maximum Performance Across 3 Weightlifting Overhead Pressing Exercises and Sport Groups

2020 ◽  
Vol 15 (6) ◽  
pp. 862-867
Author(s):  
Marcos A. Soriano ◽  
Amador García-Ramos ◽  
Antonio Torres-González ◽  
Joaquín Castillo-Palencia ◽  
Pedro J. Marín ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Assessment Method ◽  
Exercise Group ◽  
Mixed Group ◽  
Training Experience ◽  
Strength And Conditioning ◽  
Repetition Maximum ◽  
Main Effect

Objective: To (1) compare the 1-repetition-maximum (1RM) performance between the push press, push jerk, and split jerk and (2) explore these differences between weightlifters, CrossFit athletes, and a mixed group of athletes. Methods: Forty-six resistance-trained males (age 28.8 [6.4] y; height 180.0 [6.0] cm; body mass 84.1 [10.2] kg; weightlifting training experience 3.64 [3.14] y) participated in this study. The 1RM performance of the push press, push jerk, and split jerk was assessed during the same session in a sequential order (ie, combined 1RM assessment method). Thirty-six participants were retested to determine between-sessions reliability of the 1RM values. Results: Intraclass correlation coefficients (ICCs) and associated 95% confidence intervals (CIs) showed a high between-sessions reliability for the push press (ICC = .98; 95% CI, .95–.99), push jerk (ICC = .99; 95% CI, .98–1.00), and split jerk (ICC = .99; 95% CI, .98–1.00). There was a significant main effect of exercise (η2 = .101) and exercise × group interaction (η2 = .012) on 1RM performance (P < .001), whereas the main effect of group did not reach statistical significance (P = .175). Conclusions: This study provides evidence that the weightlifting overhead press derivatives affect 1RM performance. In addition, the interaction of exercise and sport group was caused by the higher differences in 1RM performance between exercises for weightlifters compared with CrossFit and a mixed group of athletes. Therefore, strength and conditioning professionals should be aware that the differences in 1RM performance between weightlifting overhead-press derivatives may be affected by sport group.

scholarly journals Evaluation of the Usefulness of CO-RADS for Chest CT in Patients Suspected of Having COVID-19

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 608 ◽  
Author(s):  
Tomoyuki Fujioka ◽  
Marie Takahashi ◽  
Mio Mori ◽  
Junichi Tsuchiya ◽  
Emi Yamaga ◽  
...  
Keyword(s):  
Interobserver Agreement ◽  
Characteristic Curve ◽  
Intraclass Correlation ◽  
Ct Images ◽  
Chest Ct ◽  
Rt Pcr ◽  
Radiological Society ◽  
Significant Difference ◽  
The Individual ◽  
Sensitivity Specificity

The purpose of this study was to use the Coronavirus Disease 2019 (COVID-19) Reporting and Data System (CO-RADS) to evaluate the chest computed tomography (CT) images of patients suspected of having COVID-19, and to investigate its diagnostic performance and interobserver agreement. The Dutch Radiological Society developed CO-RADS as a diagnostic indicator for assessing suspicion of lung involvement of COVID-19 on a scale of 1 (very low) to 5 (very high). We investigated retrospectively 154 adult patients with clinically suspected COVID-19, between April and June 2020, who underwent chest CT and reverse transcription-polymerase chain reaction (RT-PCR). The patients’ average age was 61.3 years (range, 21–93), 101 were male, and 76 were RT-PCR positive. Using CO-RADS, four radiologists evaluated the chest CT images. Sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated. Interobserver agreement was calculated using the intraclass correlation coefficient (ICC) by comparing the individual reader’s score to the median of the remaining three radiologists. The average sensitivity was 87.8% (range, 80.2–93.4%), specificity was 66.4% (range, 51.3–84.5%), and AUC was 0.859 (range, 0.847–0.881); there was no significant difference between the readers (p > 0.200). In 325 (52.8%) of 616 observations, there was absolute agreement among observers. The average ICC of readers was 0.840 (range, 0.800–0.874; p < 0.001). CO-RADS is a categorical taxonomic evaluation scheme for COVID-19 pneumonia, using chest CT images, that provides outstanding performance and from substantial to almost perfect interobserver agreement for predicting COVID-19.

scholarly journals Development of a Traditional Chinese Medicine Syndrome-Specific Scale for Ulcerative Colitis: The Large Intestine Dampness-Heat Syndrome Questionnaire

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Xin-lin Chen ◽  
Yi Wen ◽  
Zu-chun Wu ◽  
Bei-ping Zhang ◽  
Zheng-kun Hou ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Large Intestine ◽  
Characteristic Curve ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Diagnostic Efficacy ◽  
Construct Definition ◽  
Traditional Chinese Medicine Syndrome ◽  
Intraclass Correlation Coefficients ◽  
Heat Syndrome

The aim of this study was to develop and validate the large intestine dampness-heat syndrome questionnaire (LIDHSQ) for patients with ulcerative colitis (UC). The domains and items of the LIDHSQ were developed according to standard procedures, namely, construct definition, item generation, language testing, content validity, pilot study, and validation study. At first, a total of 20 items in 3 domains were generated based on literature review and expert consultation. After the item selection, the LIDHSQ contains 11 items in three domains: disease-related domain (diarrhoea, abdominal pain, bloody purulent stool, and mucus stool), heat domain (fever, dry mouth, red tongue, yellow fur, and anal burning), and dampness domain (greasy fur and defecation disorder). The Cronbach's alphas of all domains were greater than 0.6. All of the intraclass correlation coefficients were greater than 0.8. The LIDHSQ and domain scores of the patients with LIDHS were higher than those of the patients with other syndromes (P < 0.001). The area under the receiver operating characteristic curve of the LIDHSQ was 0.900, with a 95% confidence interval of 0.872–0.928. When the cut-off value of the LIDHSQ was ≥ 7, the sensitivity and specificity were 0.867 and 0.854, respectively. The LIDHSQ is valid and reliable for measuring LIDHS in UC patients with good diagnostic efficacy. We recommend the use of the LIDHSQ in Chinese UC patients.

scholarly journals The Novel Technique of using Superb Microvascular Imaging to Determine Carotid Intima-media Thickness

2018 ◽  
Vol 1 ◽  
pp. 16
Author(s):  
Fatima Musarrat Hasan ◽  
Musarrat Hasan
Keyword(s):  
Interobserver Agreement ◽  
Interobserver Reliability ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Superb Microvascular Imaging ◽  
Microvascular Imaging ◽  
Near Wall

Objective The objective of this study was to investigate the interobserver reliability when measuring the carotid intima media thickness (IMT) using superb microvascular imaging (SMI) and B-mode ultrasonography. Methods Two sonologists were selected to scan the left common carotid artery and measure IMT first with B-mode and then with SMI on 20 patients. They were blinded to each other results. Intraclass correlation coefficients (ICCs) were calculated to estimate the inter-rater reliability using both the modes of scanning. Results Interobserver agreement when using SMI, for both near wall and far wall, was almost perfect (ICC, 0.870; 95% confidence interval [CI], 0.700–0.946). Interobserver agreement when using B-mode was poor for near wall (ICC, 0.396; 95% CI, −0.048–0.708) and moderate for far wall (ICC, 0.474, 95% CI, 0.070–0.749). Conclusions SMI proved to be a greatly reliable tool in the measurement of carotid IMT.

scholarly journals The interobserver reliability of the diagnosis and classification of scaphoid fractures using high-resolution peripheral quantitative CT

2020 ◽  
Vol 102-B (4) ◽  
pp. 478-484 ◽  
Author(s):  
Anne M. Daniels ◽  
Caroline E. Wyers ◽  
Heinrich M. J. Janzing ◽  
Sander Sassen ◽  
Daan Loeffen ◽  
...  
Keyword(s):  
High Resolution ◽  
Interobserver Agreement ◽  
Interobserver Reliability ◽  
Scaphoid Fracture ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Kappa Statistics ◽  
Quantitative Ct ◽  
Scaphoid Fractures

Aims Besides conventional radiographs, the use of MRI, CT, and bone scintigraphy is frequent in the diagnosis of a fracture of the scaphoid. However, which techniques give the best results remain unknown. The investigation of a new imaging technique initially requires an analysis of its precision. The primary aim of this study was to investigate the interobserver agreement of high-resolution peripheral quantitative CT (HR-pQCT) in the diagnosis of a scaphoid fracture. A secondary aim was to investigate the interobserver agreement for the presence of other fractures and for the classification of scaphoid fracture. Methods Two radiologists and two orthopaedic trauma surgeons evaluated HR-pQCT scans of 31 patients with a clinically-suspected scaphoid fracture. The observers were asked to determine the presence of a scaphoid or other fracture and to classify the scaphoid fracture based on the Herbert classification system. Fleiss kappa statistics were used to calculate the interobserver agreement for the diagnosis of a fracture. Intraclass correlation coefficients (ICCs) were used to assess the agreement for the classification of scaphoid fracture. Results A total of nine (29%) scaphoid fractures and 12 (39%) other fractures were diagnosed in 20 patients (65%) using HR-pQCT across the four observers. The interobserver agreement was 91% for the identification of a scaphoid fracture (95% confidence interval (CI) 0.76 to 1.00) and 80% for other fractures (95% CI 0.72 to 0.87). The mean ICC for the classification of a scaphoid fracture in the seven patients diagnosed with scaphoid fracture by all four observers was 73% (95% CI 0.42 to 0.94). Conclusion We conclude that the diagnosis of scaphoid and other fractures is reliable when using HR-pQCT in patients with a clinically-suspected fracture. Cite this article: Bone Joint J 2020;102-B(4):478–484.

scholarly journals Reliability of Measuring the Cervical Sagittal Translation Mobility with a Simple Method in a Clinical Setting

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Yvonne Severinsson ◽  
Lena Elisson ◽  
Olle Bunketorp
Keyword(s):  
Clinical Setting ◽  
Intraclass Correlation ◽  
Correlation Coefficients ◽  
Practical Method ◽  
Systematic Difference ◽  
Reference Plane ◽  
Rank Test ◽  
Rater Agreement ◽  
Simple Method ◽  
The Difference

Introduction. The cervical sagittal translation mobility is related to neck pain. A practical method for measuring the specific cervical mobility is needed. The aim was to describe a simple method for measuring the cervical sagittal translation mobility and to evaluate its reliability in a clinical setting.Method. The head protraction and retraction ranges of thirty healthy seated subjects were measured from a dorsal reference plane by two physiotherapists utilizing a tape measure. A standard inclinometer/goniometer was used to minimize angular movements of the head during the translational movements. The measurements were made twice for each subject with a two-hours interval between each measurement. The inter-rater and intra-rater agreements were evaluated with intraclass correlation coefficients (ICCs) and with the distribution of the difference of the measurements. The systematic differences were analysed with the Wilcoxon signed rank test.Results. The intra-rater agreement was good. The inter-rater agreement was moderate in the first measurement and good in the second. A systematic difference was noted between raters in the first measurement but not in the second, possibly indicating a learning effect.Discussion. The method used in the study is simple and reliable and can be recommended for clinical use.

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