scholarly journals Mucosa-associated lymphoid tissue lymphoma of the parotid gland – a case report

2021 ◽  
Author(s):  
Delia Muntean ◽  
Sorin Dudea ◽  
Manuela Lenghel ◽  
Carolina Solomon ◽  
Teodora Iuga ◽  
...  
Keyword(s):  
Parotid Gland ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Malt Lymphoma ◽  
Lymphoid Tissue ◽  
Cell Lineage ◽  
Malignant Tumour ◽  
Needle Aspiration ◽  
Non Hodgkin Lymphoma ◽  
Mri Features

Mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland is a rare entity among head and neck tumours. We report a case of a patient with a medical history of diffuse large B-cell Non-Hodgkin Lymphoma with complete remission following chemotherapy, who presented seven years afterwards with a progressive painless hard swelling of the right parotidgland. Ultrasonography followed by contrast-enhanced MRI features was consistent with a malignant tumour. Consequently, fine and core needle aspiration biopsy were performed under ultrasound guidance and the final histopathological result was MALT lymphoma of the parotid gland. The most important particularity of the case is the sequential development of two different histopathological types of Non-Hodgkin Lymphoma, both of B-cell lineage.

E6-Associated Protein (E6-AP): A Potential Tumor Suppressor Protein for Non-Hodgkin Lymphoma.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4336-4336
Author(s):  
Shazia Zafar ◽  
Sathish Srinivasan ◽  
Zafar Nawaz
Keyword(s):  
T Cell ◽  
Tumor Suppressor ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Lymphoid Tissue ◽  
Tumor Suppressor Genes ◽  
Tumor Suppressor Protein ◽  
Non Hodgkin Lymphoma ◽  
T Cell Lymphomas ◽  
Potential Tumor Suppressor

Abstract Over the past decade considerable progress has been made in cloning and characterization of potential tumor suppressor genes. Tumor suppressors have a repressive effect on the regulation of the cell cycle or promote apoptosis and sometimes do both. The function of tumor suppressor proteins fall into several categories, tumor suppressor genes are presumed to encode negative regulator of proliferation and inhibit mitotic activity. Loss of tumor suppressor protein or function of a tumor suppressor protein has been shown to be associated with the cancer formation. Continued investigation into the biochemical and cell biological functions of the tumor suppressor is critical to elucidate the mechanisms by which they normally inhibit proliferation/tumor development and to provide a molecular explanation for their frequent inactivation in cancer. Our laboratory has previously shown that the expression of E6-associated protein (E6-AP), which is an E3 ubiquitin-protein ligase and a coactivator of nuclear hormone receptors, is significantly reduced in human cancers having epithelial cell origin such as breast cancer. In this prospective study, we want to extend our observation to the cancers originating from lymphoid tissue. Non-Hodgkin lymphoma is a cancer of lymphoid tissue. The main cell type found in lymphoid tissue is the lymphocyte. The 2 main types of lymphocytes are B-lymphocytes (B-cells) and T-lymphocytes (T-cells). B-cell lymphomas are much more common than T-cell lymphomas. In the U. S., 85% of all cases of non-Hodgkin lymphoma come from B lymphocytes (B-cell) and 15% from T lymphocytes (T-cell). We performed immunohistochemistry analysis to investigate the expression pattern of E6-AP in normal lymph nodes and lymphoid tumors. Tissue micro arrays representing samples from 60 different patients were analyzed in this study. Our analysis suggest that on an average there was about 55 % reduction in E6-AP protein levels in B-cell lymphomas (P =0.0001) and 98.5 % reduction in E6-AP levels in T-cell lymphomas (P =0.0002) compared to normal lymph node. Based on our previous studies in breast and prostate tumors and considering our current finding of reduced/loss of E6-AP in lymphoid tumors, we propose that E6-AP may act as a potential tumor suppressor protein. This proposed idea is consistent with our in vivo data generated from E6-AP null mice which shows that the number of B- and T-cells are significantly increased in spleen compared to normal wild-type animals. Taken together our data establish the role of E6-AP as a potential growth and tumor suppressor protein.

scholarly journals Gastrointestinal Tract Lymphomas: A Review of the Most Commonly Encountered Lymphomas

2021 ◽  
Author(s):  
Jessica Alvarez-Lesmes ◽  
Jennifer R. Chapman ◽  
Daniel Cassidy ◽  
Yi Zhou ◽  
Monica Garcia-Buitrago ◽  
...  
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lineage ◽  
B Cell Lymphoma ◽  
Gi Tract ◽  
Common Site ◽  
Anatomic Site ◽  
Non Hodgkin Lymphoma ◽  
Pubmed Database ◽  
Data Source

Context.— The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin lymphoma, accounting for 20% to 40% of all extranodal lymphomas. The majority of these are systemic processes secondarily involving the GI tract. Primary GI lymphomas are less common, accounting for approximately 10% to 15% of all non-Hodgkin lymphoma. Most non-Hodgkin lymphoma involving the GI tract are of B-cell lineage, of which diffuse large B-cell lymphoma is the most common subtype, irrespective of location. Objective.— To review the lymphoproliferative neoplasms of B-cell and T-cell lineage involving the luminal GI tract according to the most prevalent subtypes at each anatomic site. Data Source.— Systematic search of the PubMed database for updated literature on GI lymphomas epidemiology, subtypes, clinical, endoscopic, and genetic findings. Histologic images are derived from our collection of clinical cases. Conclusions.— The GI tract is the most common site of extranodal lymphoproliferative neoplasms. Recognition of the most frequently encountered GI lymphomas is imperative for patient management and treatment.

The Value of Fluorescence In Situ Hybridization and Polymerase Chain Reaction in the Diagnosis of B-Cell Non-Hodgkin Lymphoma by Fine-Needle Aspiration

2004 ◽  
Vol 128 (12) ◽  
pp. 1395-1403 ◽  
Author(s):  
Anne M. Safley ◽  
Patrick J. Buckley ◽  
Andrew J. Creager ◽  
Rajesh C. Dash ◽  
Leslie G. Dodd ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Fine Needle Aspiration ◽  
Cell Lymphoma ◽  
Molecular Genetic ◽  
Needle Aspiration ◽  
Low Grade ◽  
Fine Needle ◽  
Non Hodgkin Lymphoma

Abstract Context.—Molecular genetic analyses have been predicted to improve the diagnostic accuracy of fine-needle aspiration of B-cell non-Hodgkin lymphoma. Objective.—To determine the value of routine molecular genetic assays, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH), in the diagnosis of B-cell non-Hodgkin lymphoma by fine-needle aspiration (FNA). Design.—A multiparametric method, including cytology, flow cytometry, PCR, and FISH, was prospectively evaluated in the diagnosis of B-cell non-Hodgkin lymphoma by FNA. Aspirates from 30 consecutive patients with suspected hematolymphoid malignancies were collected. All aspirates were triaged through a uniform program including cell-size analysis, B- and T-cell clonality studies, flow cytometric immunophenotyping, and bcl-1 and bcl-2 gene rearrangements by PCR and FISH. After completion of FNA evaluations, FNA results were compared with diagnoses from prior or subsequent surgical biopsies. Results.—Monoclonal B-cell populations were detected in 18 of 20 B-cell non-Hodgkin lymphomas by flow cytometry and PCR. bcl-1 gene rearrangement was detected in 2 of 2 cases of mantle cell lymphoma. bcl-2 rearrangement was detected in 5 cases including 4 of 4 low-grade follicular lymphomas and 1 transformed follicular lymphoma. By incorporating the results of molecular genetic and ancillary diagnostics, a definitive classification was reached in 12 cases of B-cell non-Hodgkin lymphoma by FNA, including all cases of low-grade follicular lymphoma (4/4) and mantle cell lymphoma (2/2) and approximately 50% of small lymphocytic lymphoma (2/4) and large B-cell lymphoma (4/8). Ten of the 12 cases with a final classification reached by FNA had either prior or follow-up surgical biopsies, and all 10 cases showed agreement between the diagnoses rendered on FNA and surgical biopsies. Conclusions.—With proper handling and management of specimens, FNA can routinely provide samples adequate for molecular genetic studies, in addition to cytomorphology and flow cytometry, making it possible to consistently render accurate and definitive diagnoses in a subset of B-cell non-Hodgkin lymphomas. By incorporating FISH and PCR methods, FNA may assume an expanded role for the primary diagnosis of B-cell non-Hodgkin lymphoma.

scholarly journals Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1019
Author(s):  
Paola Parente ◽  
Magda Zanelli ◽  
Francesca Sanguedolce ◽  
Luca Mastracci ◽  
Paolo Graziano
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Cell Lineage ◽  
Clinicopathological Correlation ◽  
Therapeutic Approaches ◽  
Similar Morphology ◽  
Non Hodgkin Lymphoma ◽  
Classic Hodgkin Lymphoma ◽  
Lineage Markers ◽  
Small Clusters

Reed–Sternberg cells (RSCs) are hallmarks of classic Hodgkin lymphoma (cHL). However, cells with a similar morphology and immunophenotype, so-called Reed–Sternberg-like cells (RSLCs), are occasionally seen in both B cell and T cell non-Hodgkin Lymphomas (NHLs). In NHLs, RSLCs are usually present as scattered elements or in small clusters, and the typical background microenviroment of cHL is usually absent. Nevertheless, in NHLs, the phenotype of RSLCs is very similar to typical RSCs, staining positive for CD30 and EBV, and often for B cell lineage markers, and negative for CD45/LCA. Due to different therapeutic approaches and prognostication, it is mandatory to distinguish between cHL and NHLs. Herein, NHL types in which RSLCs can be detected along with clinicopathological correlation are described. Moreover, the main helpful clues in the differential diagnosis with cHL are summarized.

B-cell non-Hodgkin lymphoma and pseudo-Gaucher cells in a lymph node fine needle aspiration

Cytopathology ◽  
2015 ◽  
Vol 27 (2) ◽  
pp. 134-136 ◽  
Author(s):  
I. Cozzolino ◽  
M. Picardi ◽  
S. Pagliuca ◽  
G. Ciancia ◽  
L. Luigia ◽  
...  
Keyword(s):  
Lymph Node ◽  
B Cell ◽  
Hodgkin Lymphoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Non Hodgkin Lymphoma

scholarly journals Mucosa-associated lymphoid tissue lymphoma arising from the kidney

2014 ◽  
Vol 8 (1-2) ◽  
pp. 86 ◽  
Author(s):  
Naoya Niwa ◽  
Nobuyuki Tanaka ◽  
Minoru Horinaga ◽  
Hiroshi Hongo ◽  
Yujiro Ito ◽  
...  
Keyword(s):  
B Cell ◽  
Malt Lymphoma ◽  
Burkitt Lymphoma ◽  
Lymphoid Tissue ◽  
Cell Lymphoma ◽  
Cell Lineage ◽  
B Cell Lymphoma ◽  
Low Grade ◽  
High Grade ◽  
Renal Lymphoma

Primary renal lymphoma is rare, and most are intermediate- and high-grade lymphomas of B-cell lineage, such as diffuse large B-cellor Burkitt lymphoma. We report a case of low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) arising from the kidney. Only a few cases of primary renal MALT lymphoma have been published.

scholarly journals Ocular non-Hodgkin lymphoma: a report of two cases and review of the literature

Mediscope ◽  
2018 ◽  
Vol 5 (2) ◽  
pp. 36-41
Author(s):  
R Paul ◽  
UK Kundu ◽  
E Kabir ◽  
MN Islam
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Review Of The Literature ◽  
Unusual Site ◽  
Fine Needle ◽  
Non Hodgkin Lymphoma ◽  
First Case ◽  
Left Eyelid

In this article, two cases of non-Hodgkin lymphomas (NHL) occurring at an unusual site were reported. The first case was a male patient aged 60 years hailing from Debidwar, Comilla came with the complaint of gradually increasing mass in the left eyelid for two years. Fine-needle aspiration (FNA) and histopathology of his lesion revealed NHL, which on immunohistochemistry showed to be of B-cell origin. A debulking operation was done in National Institute of Ophthalmology & Hospital, Dhaka and he was sent for chemotherapy. The second case was also a male aged 35 years from Muladi, Barisal who presented with gradually increasing bilateral masses on both the upper eyelids for six months. The results of FNA of the eyelid tumors were suggestive of NHL that was subsequently confirmed by histopathology. Immunohistochemistry showed the tumor to be of B-cell origin.Mediscope Vol. 5, No. 2: Jul 2018, Page 36-41

Fine needle aspiration as a diagnostic technique in B-cell non-hodgkin lymphoma

2014 ◽  
Vol 42 (8) ◽  
pp. S61
Author(s):  
Amani Sorour ◽  
Maged Mikhail ◽  
Nahala Farahat ◽  
Ashraf Elghandour ◽  
Hanna Donia
Keyword(s):  
B Cell ◽  
Hodgkin Lymphoma ◽  
Fine Needle Aspiration ◽  
Diagnostic Technique ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Non Hodgkin Lymphoma
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