scholarly journals Transfer learning with pre-trained deep convolutional neural networks for the automatic assessment of liver steatosis in ultrasound images

2020 ◽  
Author(s):  
Elena Codruta Constantinescu ◽  
Anca-Loredana Udriștoiu ◽  
Ștefan Cristinel Udriștoiu ◽  
Andreea Valentina Iacob ◽  
Lucian Gheorghe Gruionu ◽  
...  

Aim: In this paper we proposed different architectures of convolutional neural network (CNN) to classify fatty liver disease in images using only pixels and diagnosis labels as input. We trained and validated our models using a dataset of 629 images consisting of 2 types of liver images, normal and liver steatosis. Material and methods: We assessed two pre-trained models of convolutional neural networks, Inception-v3 and VGG-16 using fine-tuning. Both models were pre-trained on ImageNet dataset to extract features from B-mode ultrasound liver images. The results obtained through these methods were compared for selecting the predictive model with the best performance metrics. We trained the two models using a dataset of 262 images of liver steatosis and 234 images of normal liver. We assessed the models using a dataset of 70 liver steatosis im-ages and 63 normal liver images. Results. The proposed model that used Inception v3 obtained a 93.23% test accuracy with a sensitivity of 89.9%% and a precision of 96.6%, and areas under each receiver operating characteristic curves (ROC AUC) of 0.93. The other proposed model that used VGG-16, obtained a 90.77% test accuracy with a sensitivity of 88.9% and a precision of 92.85%, and areas under each receiver operating characteristic curves (ROC AUC) of 0.91. Conclusion. The deep learning algorithms that we proposed to detect steatosis and classify the images in normal and fatty liver images, yields an excellent test performance of over 90%. However, future larger studies are required in order to establish how these algorithms can be implemented in a clinical setting.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yanfei Li ◽  
Xianying Feng ◽  
Yandong Liu ◽  
Xingchang Han

AbstractThis work researched apple quality identification and classification from real images containing complicated disturbance information (background was similar to the surface of the apples). This paper proposed a novel model based on convolutional neural networks (CNN) which aimed at accurate and fast grading of apple quality. Specific, complex, and useful image characteristics for detection and classification were captured by the proposed model. Compared with existing methods, the proposed model could better learn high-order features of two adjacent layers that were not in the same channel but were very related. The proposed model was trained and validated, with best training and validation accuracy of 99% and 98.98% at 2590th and 3000th step, respectively. The overall accuracy of the proposed model tested using an independent 300 apple dataset was 95.33%. The results showed that the training accuracy, overall test accuracy and training time of the proposed model were better than Google Inception v3 model and traditional imaging process method based on histogram of oriented gradient (HOG), gray level co-occurrence matrix (GLCM) features merging and support vector machine (SVM) classifier. The proposed model has great potential in Apple’s quality detection and classification.


Author(s):  
Wanyun Zhang ◽  
Zhijun Chen ◽  
Han Zhang ◽  
Guannan Su ◽  
Rui Chang ◽  
...  

Fuchs’ uveitis syndrome (FUS) is one of the most under- or misdiagnosed uveitis entities. Many undiagnosed FUS patients are unnecessarily overtreated with anti-inflammatory drugs, which may lead to serious complications. To offer assistance for ophthalmologists in the screening and diagnosis of FUS, we developed seven deep convolutional neural networks (DCNNs) to detect FUS using slit-lamp images. We also proposed a new optimized model with a mixed “attention” module to improve test accuracy. In the same independent set, we compared the performance between these DCNNs and ophthalmologists in detecting FUS. Seven different network models, including Xception, Resnet50, SE-Resnet50, ResNext50, SE-ResNext50, ST-ResNext50, and SET-ResNext50, were used to predict FUS automatically with the area under the receiver operating characteristic curves (AUCs) that ranged from 0.951 to 0.977. Our proposed SET-ResNext50 model (accuracy = 0.930; Precision = 0.918; Recall = 0.923; F1 measure = 0.920) with an AUC of 0.977 consistently outperformed the other networks and outperformed general ophthalmologists by a large margin. Heat-map visualizations of the SET-ResNext50 were provided to identify the target areas in the slit-lamp images. In conclusion, we confirmed that a trained classification method based on DCNNs achieved high effectiveness in distinguishing FUS from other forms of anterior uveitis. The performance of the DCNNs was better than that of general ophthalmologists and could be of value in the diagnosis of FUS.


2021 ◽  
pp. 096228022199595
Author(s):  
Yalda Zarnegarnia ◽  
Shari Messinger

Receiver operating characteristic curves are widely used in medical research to illustrate biomarker performance in binary classification, particularly with respect to disease or health status. Study designs that include related subjects, such as siblings, usually have common environmental or genetic factors giving rise to correlated biomarker data. The design could be used to improve detection of biomarkers informative of increased risk, allowing initiation of treatment to stop or slow disease progression. Available methods for receiver operating characteristic construction do not take advantage of correlation inherent in this design to improve biomarker performance. This paper will briefly review some developed methods for receiver operating characteristic curve estimation in settings with correlated data from case–control designs and will discuss the limitations of current methods for analyzing correlated familial paired data. An alternative approach using conditional receiver operating characteristic curves will be demonstrated. The proposed approach will use information about correlation among biomarker values, producing conditional receiver operating characteristic curves that evaluate the ability of a biomarker to discriminate between affected and unaffected subjects in a familial paired design.


Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1263
Author(s):  
Zhaojun Wang ◽  
Jiangning Wang ◽  
Congtian Lin ◽  
Yan Han ◽  
Zhaosheng Wang ◽  
...  

With the rapid development of digital technology, bird images have become an important part of ornithology research data. However, due to the rapid growth of bird image data, it has become a major challenge to effectively process such a large amount of data. In recent years, deep convolutional neural networks (DCNNs) have shown great potential and effectiveness in a variety of tasks regarding the automatic processing of bird images. However, no research has been conducted on the recognition of habitat elements in bird images, which is of great help when extracting habitat information from bird images. Here, we demonstrate the recognition of habitat elements using four DCNN models trained end-to-end directly based on images. To carry out this research, an image database called Habitat Elements of Bird Images (HEOBs-10) and composed of 10 categories of habitat elements was built, making future benchmarks and evaluations possible. Experiments showed that good results can be obtained by all the tested models. ResNet-152-based models yielded the best test accuracy rate (95.52%); the AlexNet-based model yielded the lowest test accuracy rate (89.48%). We conclude that DCNNs could be efficient and useful for automatically identifying habitat elements from bird images, and we believe that the practical application of this technology will be helpful for studying the relationships between birds and habitat elements.


2021 ◽  
Author(s):  
Xinshi Huang ◽  
Xiaobing Wang ◽  
Dinglai Yu

Abstract Objective To establish and validate a nomogram for individualized prediction of renal involvement in pSS patients. Methods A total of 1293 patients with pSS from the First Affiliated Hospital of Wenzhou Medical University between January 2008 to January 2020 were recruited and further analyzed retrospectively. The patients were randomly divided into a development set (70%, n = 910) and a validation set (30%, n = 383). The univariable and multivariate logistic regression were performed to analyze the risk factors of renal involvement in pSS. Based on the regression β coefficients derived from multivariate logistic analysis, an individualized nomogram prediction model was developed. The prediction model of discrimination and calibration was evaluated with the area under the receiver operating characteristic curves and Calibration plot. Results Multivariate logistic analysis showed that hypertension, anemia, albumin, uric acid, anti-Ro52, hematuria and Chisholm-Mason grade were independent risk factors of renal involvement in pSS. The area under the receiver operating characteristic curves were 0.797 and 0.750 respectively in development set and validation set, indicating the nomogram had a good discrimination capacity. The Calibration plot showed nomogram had a strong concordance performance between the prediction probability and the actual probability. Conclusion The individualized nomogram for pSS patients those who had renal involvement could be used by clinicians to predict the risk of pSS patients developing into renal involvement and improve early screening and intervention.


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