Capture of Magnetic Microspheres in Electrokinetic Flow for Application in Lab-on-Chip Devices

2012 ◽  
Author(s):  
Debarun Das ◽  
Marwan Al-Rjoub ◽  
Jagjit S. Yadav ◽  
Rupak K. Banerjee
Keyword(s):  
Magnetic Field ◽  
Electric Fields ◽  
Magnetic Beads ◽  
Magnetic Microspheres ◽  
Electrokinetic Flow ◽  
Lab On Chip ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
On Chip ◽  
The Magnetic Field

Isolation of bio-molecules, cells and pathogens for immunoassays is a critical component in micro total analysis systems (μTAS). Magnetophoretic technique is often used for separation of such target species, where magnetic beads tagged with specific antibodies against cell surface epitopes, are captured in the microfluidic device. In this study, a numerical model is developed for capture of beads under an external magnetic field in electrokinetically driven flow. The results indicate an increase in the number of beads captured when the magnetic field is higher and the flow is driven by lower electric fields.

scholarly journals Mapping of steady-state electric fields and convective drifts in geomagnetic fields – Part 1: Elementary models

2016 ◽  
Vol 34 (1) ◽  
pp. 55-65 ◽  
Author(s):  
A. D. M. Walker ◽  
G. J. Sofko
Keyword(s):  
Magnetic Field ◽  
Steady State ◽  
Electric Field ◽  
Electric Fields ◽  
Magnetic Field Line ◽  
Geomagnetic Field ◽  
Geomagnetic Field Models ◽  
Spatial Derivatives ◽  
Field Lines ◽  
The Magnetic Field

Abstract. When studying magnetospheric convection, it is often necessary to map the steady-state electric field, measured at some point on a magnetic field line, to a magnetically conjugate point in the other hemisphere, or the equatorial plane, or at the position of a satellite. Such mapping is relatively easy in a dipole field although the appropriate formulae are not easily accessible. They are derived and reviewed here with some examples. It is not possible to derive such formulae in more realistic geomagnetic field models. A new method is described in this paper for accurate mapping of electric fields along field lines, which can be used for any field model in which the magnetic field and its spatial derivatives can be computed. From the spatial derivatives of the magnetic field three first order differential equations are derived for the components of the normalized element of separation of two closely spaced field lines. These can be integrated along with the magnetic field tracing equations and Faraday's law used to obtain the electric field as a function of distance measured along the magnetic field line. The method is tested in a simple model consisting of a dipole field plus a magnetotail model. The method is shown to be accurate, convenient, and suitable for use with more realistic geomagnetic field models.

The Research of a New Method for Manipulating Magnetic Beads through Multi-Layered Flat Micro-Coils Coupled with Permanent Magnet

2013 ◽  
Vol 753-755 ◽  
pp. 1571-1575
Author(s):  
Zhi Hua Liu ◽  
Yu Feng Huang ◽  
Jian Peng Li ◽  
Xin Wei Xu
Keyword(s):  
Magnetic Field ◽  
Permanent Magnet ◽  
Flow Velocity ◽  
Magnetic Beads ◽  
Magnetic Bead ◽  
New Method ◽  
Viscous Resistance ◽  
Main Factors ◽  
The Magnetic Field

Magnetic bead droplet's non-contacted manipulation can be realized in Electromagnetic MEMS, but how to achieve magnetic beads manipulation is the major problem. A new method of multi-layered flat coils coupled with permanent magnet was proposed. Firstly, the theory of magnetic bead manipulation was analyzed and the main factors affected the magnetic beads manipulation was identified; then the magnetic field of multi-layered flat coils and Stokes viscous resistance of magnetic beads were analyzed and simulated quantificationally; finally the magnetic bead capture area was got under different flow velocity. Consequently the feasibility and correctness of this method was verified.

Design Techniques for Microfluidic Devices Implementation Applicable to Chemical Analysis Systems

2019 ◽  
pp. 195-222 ◽  
Author(s):  
Reinaldo Lucas dos Santos Rosa ◽  
Antonio Carlos Seabra
Keyword(s):  
Chemical Analysis ◽  
Solid Phase ◽  
Microfluidic Devices ◽  
Water Quality Monitoring ◽  
Analysis Process ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
On Chip ◽  
Separation Cell ◽  
High Level

This chapter provides a guide for microfluidic devices development and optimization focused on chemical analysis applications, which includes medicine, biology, chemistry, and environmental monitoring, showing high-level performance associated with a specific functionality. Examples are chemical analysis, solid phase extraction, chromatography, immunoassay analysis, protein and DNA separation, cell sorting and manipulation, cellular biology, and mass spectrometry. In this chapter, most information is related to microfluidic devices design and fabrication used to perform several steps concerning chemical analysis, process preparation of reagents, samples reaction and detection, regarding water quality monitoring. These steps are especially relevant to lab-on-chip (LOC) and micro-total-analysis-systems (μTAS). μTAS devices are developed in order to simplify analytical chemist work, incorporating several analytical procedures into flow systems. In the case of miniaturized devices, the analysis time is reduced, and small volumes (nL) can be used.

INFLUENCE OF THE MAGNETIC FIELD ON THE TRANSVERSE RUNAWAY THRESHOLD

2007 ◽  
Vol 21 (10) ◽  
pp. 1715-1720 ◽  
Author(s):  
NANA METREVELI ◽  
ZAUR KACHLISHVILI ◽  
BEKA BOCHORISHVILI
Keyword(s):  
Magnetic Field ◽  
Electric Field ◽  
Electric Fields ◽  
Applied Electric Field ◽  
Nonlinear Oscillations ◽  
Hot Electrons ◽  
Total Field ◽  
Practical Applications ◽  
Energy And Momentum ◽  
The Magnetic Field

The transverse runaway (TR) is a phenomenon whereby for a certain combination of energy and momentum scattering mechanisms of hot electrons, and for a certain threshold of the applied electric field, the internal (total) field tends to infinity. In this work, the effect of the magnetic field on the transverse runaway threshold is considered. It is shown that with increasing magnetic field, the applied critical electric fields relevant to TR decrease. The obtained results are important for practical applications of the TR effect as well as for the investigation of possible nonlinear oscillations that may occur near the TR threshold.

ELECTROMAGNETIC FIELDS IN AN N‐LAYER ANISOTROPIC HALF‐SPACE

Geophysics ◽  
1967 ◽  
Vol 32 (4) ◽  
pp. 668-677 ◽  
Author(s):  
Douglas P. O’Brien ◽  
H. F. Morrison
Keyword(s):  
Magnetic Field ◽  
Experimental Data ◽  
Plane Wave ◽  
Half Space ◽  
Electric Fields ◽  
Field Measurements ◽  
Large Scatter ◽  
Tensor Impedance ◽  
The Magnetic Field ◽  
Made In

From Maxwell’s equations and Ohm’s law for a horizontally anisotropic medium, it may be shown that two independent plane wave modes propagate perpendicular to the plane of the anisotropy. Boundary conditions at the interfaces in an n‐layered model permit the calculation, through successive matrix multiplications, of the fields at the surface in terms of the fields propagated into the basal infinite half space. Specifying the magnetic field at the surface allows the calculation of the resultant electric fields, and the calculation of the entries of a tensor impedance relationship. These calculations have been programmed for the digital computer and an interpretation of impedances obtained from field measurements may thus be made in terms of the anisotropic layering. In addition, apparent resistivities in orthogonal directions have been calculated for specific models and compared to experimental data. It is apparent that the large scatter of observed resistivities can be caused by small changes in the polarization of the magnetic field.

scholarly journals Ion energy increase in laser-generated plasma expanding through axial magnetic field trap

2007 ◽  
Vol 25 (3) ◽  
pp. 453-464 ◽  
Author(s):  
L. Torrisi ◽  
D. Margarone ◽  
S. Gammino ◽  
L. Andò
Keyword(s):  
Magnetic Field ◽  
Electric Field ◽  
Electric Fields ◽  
Axial Magnetic Field ◽  
Ion Beam ◽  
High Vacuum ◽  
Target Surface ◽  
Axial Direction ◽  
Ion Interactions ◽  
The Magnetic Field

Laser-generated plasma is obtained in high vacuum (10−7 mbar) by irradiation of metallic targets (Al, Cu, Ta) with laser beam with intensities of the order of 1010 W/cm2. An Nd:Yag laser operating at 1064 nm wavelength, 9 ns pulse width, and 500 mJ maximum pulse energy is used. Time of flight measurements of ion emission along the direction normal to the target surface were performed with an ion collector. Measurements with and without a 0.1 Tesla magnetic field, directed along the normal to the target surface, have been taken for different target-detector distances and for increasing laser pulse intensity. Results have demonstrated that the magnetic field configuration creates an electron trap in front of the target surface along the axial direction. Electric fields inside the trap induce ion acceleration; the presence of electron bundles not only focuses the ion beam but also increases its energy, mean charge state and current. The explanation of this phenomenon can be found in the electric field modification inside the non-equilibrium plasma because of an electron bunching that increases the number of electron-ion interactions. The magnetic field, in fact, modifies the electric field due to the charge separation between the clouds of fast electrons, many of which remain trapped in the magnetic hole, and slow ions, ejected from the ablated target; moreover it increases the number of electron-ion interactions producing higher charge states.

scholarly journals Time development of electric fields and currents in space plasmas

2006 ◽  
Vol 24 (3) ◽  
pp. 1137-1143
Author(s):  
A. T. Y. Lui
Keyword(s):  
Magnetic Field ◽  
Electric Current ◽  
Electric Fields ◽  
Time Development ◽  
Space Plasmas ◽  
Simplifying Assumptions ◽  
Electric Fields And Currents ◽  
Definition Of ◽  
The Magnetic Field ◽  
Made In

Abstract. Two different approaches, referred to as Bu and Ej, can be used to examine the time development of electric fields and currents in space plasmas based on the fundamental laws of physics. From the Bu approach, the required equation involves the generalized Ohm's law with some simplifying assumptions. From the Ej approach, the required equation can be derived from the equation of particle motion, coupled self-consistently with Maxwell's equation, and the definition of electric current density. Recently, some strong statements against the Ej approach have been made. In this paper, we evaluate these statements by discussing (1) some limitations of the Bu approach in solving the time development of electric fields and currents, (2) the procedure in calculating self-consistently the time development of the electric current in space plasmas without taking the curl of the magnetic field in some cases, and (3) the dependency of the time development of magnetic field on electric current. It is concluded that the Ej approach can be useful to understand some magnetospheric problems. In particular, statements about the change of electric current are valid theoretical explanations of change in magnetic field during substorms.

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