Longitudinal Variation in the Mechanical Properties of the Posterior Side of Thoracic Aorta is Larger Than Those of the Anterior Side During the Inflation Test

2012 ◽  
Author(s):  
Jungsil Kim ◽  
Alexander Dupay ◽  
Seungik Baek
Keyword(s):  
Mechanical Properties ◽  
Regional Difference ◽  
Arterial Wall ◽  
Vascular Diseases ◽  
The Elderly ◽  
Biomechanical Properties ◽  
Still Life ◽  
Computational Biomechanics ◽  
Aortic Aneurysm And Dissection ◽  
Life Threatening

The mechanical properties of arterial wall have been assumed isotropic and homogeneous, but advances in biomedical imaging and computational biomechanics bring a need for understanding regional difference in the biomechanical properties of arties. Particularly, vascular diseases such as aortic aneurysm and dissection are likely to be developed in the elderly and they are still life-threatening. Thus understanding of the regional variation in the mechanical behavior of arteries is critical for the clinical treatments and biomedical engineering applications.

Biomechanical Properties of the Stifle Joint Lateral Collateral Ligament in Dogs

1992 ◽  
Vol 05 (04) ◽  
pp. 158-162 ◽  
Author(s):  
D. Blackketter ◽  
J Harari ◽  
J. Dupuis
Keyword(s):  
Mechanical Properties ◽  
Cruciate Ligament ◽  
Lateral Collateral Ligament ◽  
Biomechanical Properties ◽  
Fibular Head ◽  
Joint Stability ◽  
Collateral Ligament ◽  
Cranial Cruciate Ligament ◽  
Stifle Joint

Bone/lateral collateral ligament/bone preparations were tested and structural mechanical properties compared to properties of cranial cruciate ligament in 15 dogs. The lateral collateral ligament has sufficient stiffness to provide stifle joint stability and strength to resist acute overload following fibular head transposition.

scholarly journals New and emerging yeast pathogens.

1995 ◽  
Vol 8 (4) ◽  
pp. 462-478 ◽  
Author(s):  
K C Hazen
Keyword(s):  
Systemic Disease ◽  
Venous Catheter ◽  
The Elderly ◽  
Emerging Pathogens ◽  
Central Venous Catheter Removal ◽  
Hansenula Anomala ◽  
Life Threatening ◽  
Rhodotorula Species ◽  
Seriously Ill Patients ◽  
Trichosporon Beigelii

The most common yeast species that act as agents of human disease are Candida albicans, Candida tropicalis, Candida glabrata, Candida parapsilosis, and Cryptococcus neoformans. The incidence of infections by other yeasts has increased during the past decade. The most evident emerging pathogens are Malassezia furfur, Trichosporon beigelii, Rhodotorula species, Hansenula anomala, Candida lusitaniae, and Candida krusei. Organisms once considered environmental contaminants or only industrially important, such as Candida utilis and Candida lipolytica, have now been implicated as agents of fungemia, onychomycosis, and systemic disease. The unusual yeasts primarily infect immunocompromised patients, newborns, and the elderly. The role of central venous catheter removal and antifungal therapy in patient management is controversial. The antibiograms of the unusual yeasts range from resistant to the most recent azoles and amphotericin B to highly susceptible to all antifungal agents. Current routine methods for yeast identification may be insufficient to identify the unusual yeasts within 2 days after isolation. The recognition of unusual yeasts as agents of sometimes life-threatening infection and their unpredictable antifungal susceptibilities increase the burden on the clinical mycology laboratory to pursue complete species identification and MIC determinations. Given the current and evolving medical practices for management of seriously ill patients, further evaluations of the clinically important data about these yeasts are needed.

MECHANICAL PROPERTIES CHANGE IN THE RAT XENOGRAFT MODEL TREATED BY MESENCHYMAL CELLS CULTURED IN AN HYALURONIC ACID-BASED HYDROGEL

2018 ◽  
Vol 18 (05) ◽  
pp. 1850047
Author(s):  
MUSTAPHA ZIDI ◽  
ERIC ALLAIRE
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Arterial Wall ◽  
Cellular Therapy ◽  
Xenograft Model ◽  
Strain Energy Function ◽  
Aortic Aneurysms ◽  
Large Strains ◽  
Abdominal Aortic ◽  
Wall Stiffness

This study investigated the efficiency of a cellular therapy with mesenchymal stem cells (MSCs) cultured in an hyaluronic acid-based hydrogel on growth of abdominal aortic aneurysms (AAA) obtained in the rat xenograft model. The experimental model was devoted to create an AAA at D14 after grafting of a decellularized abdominal aorta obtained from guinea pigs before being transplanted into rats. At D21, geometrical measurements as radius and length of AAA were performed on untreated ([Formula: see text]) and treated ([Formula: see text]) arteries. When compared to different cases, it was shown that the proposed cellular treatment significantly reduced the expansion of radius and length of AAA. Furthermore, to explore the mechanical properties change of the arterial wall, an inverse finite element method was performed where AAA is represented by an elliptical geometry with varying thicknesses. To identify the material parameters, the AAA tissue was assumed to behave isochoric and isotropic undergoing large strains and described by the Yeoh’s strain energy function. Although limitations exist in this study such as the time of the experimental protocol, the isotropic behavior law of the AAA wall and the axisymmetric geometry of the artery, the results revealed that arterial wall stiffness change and the maximum effective stress decreased during expansion of AAA when cellular treatment is applied.

Mechanical Properties and Related Histological Alterations of Engineered Tendons In Vivo

2005 ◽  
Vol 288-289 ◽  
pp. 11-14 ◽  
Author(s):  
Ting Wu Qin ◽  
Shujiang Zhang ◽  
Zhi Ming Yang ◽  
Xiang Tao Mo ◽  
Xiu Qun Li
Keyword(s):  
Mechanical Properties ◽  
Collagen Synthesis ◽  
Biomechanical Properties ◽  
Biomechanical Test ◽  
Histological Alterations ◽  
Normal Tendon ◽  
Tendon Cells ◽  
Biomechanical Stimulation

The purpose of this research is to find out the interaction between histological alterations and mechanical properties of engineered tendon implanted in situ. Defects of 0.5cm-1.0cm were made at deep flexor tendons by surgical procedure. Engineered tendons using degradable scaffolds polyglytic acid (PGA) mesh and tendon cells were implanted to repair the defects. Chickens were killed respectively at 2 weeks, 4 weeks, 6 weeks, and 8 weeks after surgery. The implants were taken out for histological examination, biomechanical test, and collagen synthesis assay. The results showed that after surgery the PGA scaffolds degraded fast and took precedence of collagen synthesis. There were not enough amount and maturation of the collagen fibers of the new tendon at 2-8 weeks after surgery. The biomechanical properties of new tendons were less than those of the normal tendon. Therefore, it is necessary to construct engineered tendons with better degradation rate of scaffolds and suitable biomechanical stimulation so that more collagen synthesis and better biomechanical properties of new tendons can be developed early after implantation.

Vascular Diseases of the Hepaticopancreaticobiliary System

2018 ◽  
pp. 388-424
Author(s):  
Kyle J. Cooper ◽  
Sara E. Smolinski-Zhao ◽  
Wael E. Saad
Keyword(s):  
Medical Management ◽  
Vascular Diseases ◽  
Biliary Tree ◽  
Natural Course ◽  
Interventional Radiologist ◽  
System P ◽  
Life Threatening ◽  
Enteric Tract ◽  
Clinical Overview

The liver, pancreas, and biliary tree exist within a complex, interconnected relationship among each other and the enteric tract. They play vital roles in endocrine physiology, metabolism, and immunity. These anatomically complex organs can be affected by a variety of vascular conditions, ranging from acute and self-limited to chronic and life-threatening. The clinical workup and management of these conditions are as important to the interventional radiologist as the procedures that they are asked to perform to treat them. Knowledge of the diseases themselves, their natural course, and medical management can help to familiarize proceduralists with the reasons for referral and the complications and comorbidities that one can expect when treating these patients. In this chapter, we present a clinical overview of vascular diseases affecting the hepaticopancreaticobiliary systems.

scholarly journals Drug compliance and the elderly: who is publishing, where, and when?

2000 ◽  
Vol 16 (1) ◽  
pp. 139-144 ◽  
Author(s):  
Jorge Juarez Vieira Teixeira ◽  
Fernando Lefèvre ◽  
Lia Lusitana Cardoso de Castro ◽  
Aracy Witt de Pinho Spínola
Keyword(s):  
Population Aging ◽  
The Elderly ◽  
Descriptive Study ◽  
Drug Prescriptions ◽  
Age Group ◽  
Drug Compliance ◽  
Potential Source ◽  
Health Related ◽  
Life Threatening

Population aging has occurred in a rather heterogeneous way worldwide. The increasing size of the elder age group highlights various health-related problems for the elderly. One such issue is non-compliance with drug prescriptions, a potential source of serious, even life-threatening problems for the patient. The authors have proposed to identify and rank countries that develop research on drug compliance among the elderly, relevant periodicals, and the frequency articles were published between January 1987 and December 1997. A descriptive study was carried out on the basis of a bibliographical review. Three databases were surveyed: MEDLINE, SOCIOFILE e LILACS. The sample included 440 articles, limited to the behavioral sphere. The number of periodicals recorded was 255, varying from one to ten articles. The number of articles published during the study period varied from 23 in 1987 to 49 in 1992, dropping to 29 in 1997. Frequency of the number of articles/year was erratic up to 1992, leveling off from 1993 on at more than double the baseline figure. The authors emphasize the need for developing multi-focused research worldwide.

scholarly journals Long Non-Coding RNA in Vascular Disease and Aging

2019 ◽  
Vol 5 (1) ◽  
pp. 26 ◽  
Author(s):  
Diewertje Bink ◽  
Noelia Lozano-Vidal ◽  
Reinier Boon
Keyword(s):  
Cardiovascular Diseases ◽  
Vascular Disease ◽  
Vascular Diseases ◽  
The Elderly ◽  
Western Society ◽  
Non Coding Rna ◽  
Number Of Patients ◽  
Non Coding Rnas ◽  
Near Future ◽  
Long Non Coding Rna

Cardiovascular diseases are the most prominent cause of death in Western society, especially in the elderly. With the increasing life expectancy, the number of patients with cardiovascular diseases will rise in the near future, leading to an increased healthcare burden. There is a need for new therapies to treat this growing number of patients. The discovery of long non-coding RNAs has led to a novel group of molecules that could be considered for their potential as therapeutic targets. This review presents an overview of long non-coding RNAs that are regulated in vascular disease and aging and which might therefore give insight into new pathways that could be targeted to diagnose, prevent, and/or treat vascular diseases.

Sign in / Sign up

Export Citation Format

Share Document