Enhancing the Mechanical Properties of Articular Cartilage Through Enzyme-Mediated Collagen Crosslinking as Regulated by Low Oxygen Tension
Keyword(s):
The Poor
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The poor ability of articular cartilage to repair following disease and injury makes the tissue a key target for reparative and regenerative medicine strategies. It has been shown that human knee joint resides under hypoxic conditions. Oxygen tension in healthy human synovium is between 7 and 11% and in articular cartilage may therefore be as low as 1–2.5% [1].