Enhancing the Mechanical Properties of Articular Cartilage Through Enzyme-Mediated Collagen Crosslinking as Regulated by Low Oxygen Tension

Author(s):  
Eleftherios A. Makris ◽  
Jerry Hu ◽  
Kyriacos A. Athanasiou

The poor ability of articular cartilage to repair following disease and injury makes the tissue a key target for reparative and regenerative medicine strategies. It has been shown that human knee joint resides under hypoxic conditions. Oxygen tension in healthy human synovium is between 7 and 11% and in articular cartilage may therefore be as low as 1–2.5% [1].

Author(s):  
Deepa R.

Oxygen is one of the most important necessities in our life such as air, water, food and vitamins. Deficiency in either the delivery or the utilization of oxygen at the tissue level leading to changes in functions, metabolisms and structures of cells and tissues of the body. A variety of pathological condition exist where the affected tissues are hypoxic or exhibit a low oxygen tension. Each of the billions of cells that make up the human body requires an adequate supply of oxygen for survival and optimum functioning. Cells and organisms are able to trigger an adaptive response to hypoxic conditions that is aimed to help them to cope with the life threatening conditions.


2004 ◽  
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pp. 1277-1286 ◽  
Author(s):  
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Christian Domm ◽  
Moonsoo Jin ◽  
Roland Sellckau ◽  
Michael Schünke

2004 ◽  
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pp. 1277-1286 ◽  
Author(s):  
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Christian Domm ◽  
Moonsoo Jin ◽  
Roland Sellckau ◽  
Michael Schünke

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