Histology-Based, Lesion-Specific Modeling of Relative Stress Distributions Indicates Plaque Rupture Unlikely in Mice

2012 ◽  
Author(s):  
Ian C. Campbell ◽  
Daiana Weiss ◽  
Renu Virmani ◽  
Raymond P. Vito ◽  
John N. Oshinski ◽  
...  
Keyword(s):  
Finite Element ◽  
Spatial Distribution ◽  
Finite Element Modeling ◽  
Plaque Rupture ◽  
Modern World ◽  
Stress Distributions ◽  
Mechanical Environment ◽  
Relative Stress ◽  
Specific Modeling ◽  
Distribution Of Stresses

Despite decades of research, atherosclerosis remains one of the leading killers in the modern world. Consequently, the atherosclerosis-prone mouse is frequently employed to study the pathophysiology of atherogenesis. To date, no investigator has conclusively observed natural plaque rupture in these commonly-studied strains. A likely explanation for the lack of observation of plaque rupture is that mouse plaques are morphologically different than human plaques and that the consequence of this difference is a solid mechanical environment in the mouse that is unlike that of humans. To investigate this possibility, we used finite element modeling based on histology specimens of mouse and human plaques to examine the spatial distribution of stresses within the walls of plaques in each organism.

Histology-Based, Lesion-Specific Modeling of Stress Differences Between Plaque Rupture and Plaque Erosion

2011 ◽  
Author(s):  
Ian C. Campbell ◽  
Renu Virmani ◽  
John N. Oshinski ◽  
W. Robert Taylor
Keyword(s):  
Finite Element ◽  
Plaque Rupture ◽  
Solid Wall ◽  
Element Model ◽  
Blood Pool ◽  
Future Studies ◽  
Fibrous Cap ◽  
Plaque Disruption ◽  
Plaque Erosion ◽  
Specific Modeling

Plaque erosion is a cause of thrombosis wherein a thrombus forms over an atherosclerotic plaque without any disruption of the fibrous cap. This is in contrast to plaque rupture, traditionally considered the main cause of atherosclerosis-related thrombosis and frequently studied in biomechanics, wherein the fibrous cap becomes disrupted and exposes the lipid core of the plaque to the blood pool. Also unlike plaque rupture, plaque erosion has been observed to happen most frequently in women [1]. Despite identification, the cause of plaque erosion remains unknown and has been virtually unstudied from a biomechanical perspective. In this study, we employ a unique high-resolution, histology-based finite element model of solid wall stresses to investigate biomechanical differences between plaque rupture and plaque erosion. In future studies, this computed stress distribution can be correlated to expression of biomarkers related to the plaque disruption process in order to investigate the cause of plaque erosion.

A New Finite Element Modeling Technique for Disbonded Adhesive Joints

2000 ◽  
Author(s):  
H.-Y. Yen ◽  
M.-H. Herman Shen
Keyword(s):  
Finite Element ◽  
Finite Element Modeling ◽  
Prediction Method ◽  
Adhesive Joints ◽  
Modeling Technique ◽  
Stress Distributions ◽  
Element Modeling ◽  
Spring Element ◽  
Bonded Joint ◽  
Finite Element Procedure

Abstract A new disbonded interface model and a finite element procedure have been developed to calculate the stress distributions of the adhesive joints with imperfectly-bonded interfaces under tensile loading. The finite element modeling of the weakened strength of the disbonded interfaces is accomplished by a new line element and a spring element. The finite element procedure consists of a new modeling technique for assessing the effects of disbonded interfaces on the stress fields of adhesive joints. The results for this work can be used as a basis for the development of the bonded joint reliability prediction method and accept/reject inspection criteria.

Finite Element Analysis of Stress Distributions on the Diamond Pick

2011 ◽  
Vol 487 ◽  
pp. 184-188
Author(s):  
Shu Tao Huang ◽  
Li Zhou ◽  
J. Li
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Finite Element Modeling ◽  
Lateral Pressure ◽  
Normal Pressure ◽  
Three Dimension ◽  
Stress Distributions ◽  
Element Analysis ◽  
Modeling Software ◽  
And Performance

Commercial finite element modeling software ANSYS was used to calculate the stress distributions of diamond pick at different loads. The three-dimension model of the pick was built and the direction and magnitude of load were varied to determine their effect on the stress distributions of diamond pick. The results show that the stresses located on the pick increase with the increasing of the normal and lateral pressure, and if the maximum normal pressure and lateral pressure are not higher than 480 kN and 150 kN, respectively, the diamond pick will not be damaged. The results obtained can provide available data for pick selection, design and performance.

Exact First Order Finite Element Modeling for Eddy Current NDE

1991 ◽  
Vol 3 (1) ◽  
pp. 235-253 ◽  
Author(s):  
L. D. Philipp ◽  
Q. H. Nguyen ◽  
D. D. Derkacht ◽  
D. J. Lynch ◽  
A. Mahmood
Keyword(s):  
Finite Element ◽  
Finite Element Modeling ◽  
Eddy Current ◽  
Element Modeling ◽  
First Order ◽  
Eddy Current Nde
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