Strong Coupled Fluid-Structure Interaction Simulation of Cerebrovascular System Using Multi-Scale Model

2012 ◽  
Author(s):  
Kengo Katagiri ◽  
Absei Krdey ◽  
Sota Yamamoto ◽  
Marie Oshima
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Shear Stress ◽  
Subarachnoid Hemorrhage ◽  
Scale Model ◽  
Cerebrovascular Disorder ◽  
Structure Interaction ◽  
Multi Scale ◽  
Interaction Simulation ◽  
Cerebrovascular System

Cerebrovascular disorder such as subarachnoid hemorrhage is the number 3 cause of death in Japan [1]. Initiation and growth of those diseases depend on hemodynamic factors such as Wall Shear Stress (WSS) or blood pressure induced by blood flow [2]. Therefore the information on the magnitude and the distribution of WSS is important to predict the consequences.

scholarly journals A nonlinear multi-scale model for blood circulation in a realistic vascular system

2021 ◽  
Vol 8 (12) ◽  
Author(s):  
Ulin Nuha A. Qohar ◽  
Antonella Zanna Munthe-Kaas ◽  
Jan Martin Nordbotten ◽  
Erik Andreas Hanson
Keyword(s):  
Blood Flow ◽  
Blood Circulation ◽  
Vascular System ◽  
Scale Model ◽  
Model Framework ◽  
Fluid Exchange ◽  
Multi Scale ◽  
Proposed Model ◽  
Porous Media Model ◽  
Capillary Bed

In the last decade, numerical models have become an increasingly important tool in biological and medical science. Numerical simulations contribute to a deeper understanding of physiology and are a powerful tool for better diagnostics and treatment. In this paper, a nonlinear multi-scale model framework is developed for blood flow distribution in the full vascular system of an organ. We couple a quasi one-dimensional vascular graph model to represent blood flow in larger vessels and a porous media model to describe flow in smaller vessels and capillary bed. The vascular model is based on Poiseuille’s Law, with pressure correction by elasticity and pressure drop estimation at vessels' junctions. The porous capillary bed is modelled as a two-compartment domain (artery and venous) using Darcy’s Law. The fluid exchange between the artery and venous capillary bed compartments is defined as blood perfusion. The numerical experiments show that the proposed model for blood circulation: (i) is closely dependent on the structure and parameters of both the larger vessels and of the capillary bed, and (ii) provides a realistic blood circulation in the organ. The advantage of the proposed model is that it is complex enough to reliably capture the main underlying physiological function, yet highly flexible as it offers the possibility of incorporating various local effects. Furthermore, the numerical implementation of the model is straightforward and allows for simulations on a regular desktop computer.

A Computational Study of Perfusion During the ExtraCorporeal Membrane Oxygenation (ECMO)

2017 ◽  
Vol 5 (1) ◽  
pp. 40-52
Author(s):  
Maria Vittoria Caruso ◽  
Vera Gramigna ◽  
Attilio Renzulli ◽  
Gionata Fragomeni
Keyword(s):  
Shear Stress ◽  
Extracorporeal Membrane Oxygenation ◽  
Computational Study ◽  
Fluid Dynamic ◽  
Scale Model ◽  
Common Procedure ◽  
Multi Scale ◽  
Membrane Oxygenation ◽  
Clinical Complications ◽  
The One

The extracorporeal membrane oxygenation (ECMO) is a common procedure of extracorporeal circulation (ECC) used in case of cardiopulmonary diseases. The major clinical complications are related to hemodynamic changes and to the mechanical shear stress. The aim of this study is to evaluate the effects of the modality of perfusion during ECMO, comparing the hemodynamic behavior generated by constant flow (normal modality) with the one obtained by pulsed perfusion induced by the intra-aortic balloon pump (IABP). To carry out the study, the computational fluid dynamic (CFD) approach was chosen, realizing a multi-scale model. The numerical results have highlighted that the IABP-induced pulsed perfusion increases both flow and pressure in the supraaortic vessels, even if the balloon makes the wall shear stress (WSS) pattern and the hemolysis index worse.

An Approach on Fluid-Structure Interaction for the Prediction of Blood Flow in Aneurysms With Various Shapes

2013 ◽  
Author(s):  
Sang Hyuk Lee ◽  
Nahmkeon Hur ◽  
Seongwon Kang
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Vascular Disease ◽  
Wall Motion ◽  
Fluid Structure Interaction ◽  
Rapid Evolution ◽  
Saccular Aneurysm ◽  
Fluid Structure ◽  
Structure Interaction ◽  
Arterial Hemodynamics

Recently, the rapid evolution of numerical methodologies for CFD and structural analyses has made it possible to predict the arterial hemodynamics closely related to vascular disease. In the present study, a framework for fluid-structure interaction (FSI) analysis was developed to accurately predict the arterial hemodynamics. The numerical results from the FSI analysis of the hemodynamics inside aneurysms of various shapes were compared to the results without FSI analysis. The results showed that FSI analysis needs to be performed in order to accurately predict the blood flow affected by the wall motion of compliant arteries. FSI analysis is essential to predict the hemodynamics in a saccular aneurysm because the arterial wall’s movement, which is a result of the variation of blood pressure in the aneurysmal sac, mainly produces the blood flow to a saccular aneurysm.

Acute cerebral blood flow response to dopamine-induced hypertension after subarachnoid hemorrhage

1994 ◽  
Vol 80 (5) ◽  
pp. 857-864 ◽  
Author(s):  
Joseph M. Darby ◽  
Howard Yonas ◽  
Elizabeth C. Marks ◽  
Susan Durham ◽  
Robert W. Snyder ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Systemic Blood Pressure ◽  
Content Type ◽  
Arterial Blood ◽  
Induced Hypertension ◽  
Fine Print

✓ The effects of dopamine-induced hypertension on local cerebral blood flow (CBF) were investigated in 13 patients suspected of suffering clinical vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The CBF was measured in multiple vascular territories using xenon-enhanced computerized tomography (CT) with and without dopamine-induced hypertension. A territorial local CBF of 25 ml/100 gm/min or less was used to define ischemia and was identified in nine of the 13 patients. Raising mean arterial blood pressure from 90 ± 11 mm Hg to 111 ± 13 mm Hg (p < 0.05) via dopamine administration increased territorial local CBF above the ischemic range in more than 90% of the uninfarcted territories identified on CT while decreasing local CBF in one-third of the nonischemic territories. Overall, the change in local CBF after dopamine-induced hypertension was correlated with resting local CBF at normotension and was unrelated to the change in blood pressure. Of the 13 patients initially suspected of suffering clinical vasospasm, only 54% had identifiable reversible ischemia. The authors conclude that dopamine-induced hypertension is associated with an increase in flow in patients with ischemia after SAH. However, flow changes associated with dopamine-induced hypertension may not be entirely dependent on changes in systemic blood pressure. The direct cerebrovascular effects of dopamine may have important, yet unpredictable, effects on CBF under clinical pathological conditions. Because there is a potential risk of dopamine-induced ischemia, treatment may be best guided by local CBF measurements.

Investigation of two-way fluid-structure interaction of blood flow in a patient-specific left coronary artery

2021 ◽  
pp. 1-18
Author(s):  
Abdulgaphur Athani ◽  
N.N.N. Ghazali ◽  
Irfan Anjum Badruddin ◽  
Sarfaraz Kamangar ◽  
Ali E. Anqi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Coronary Artery ◽  
Wall Shear Stress ◽  
Left Coronary Artery ◽  
Fluid Structure Interaction ◽  
Patient Specific ◽  
Hemodynamic Parameters ◽  
Fluid Structure ◽  
Structure Interaction

BACKGROUND: The blood flow in the human artery has been a subject of sincere interest due to its prime importance linked with human health. The hemodynamic study has revealed an essential aspect of blood flow that eventually proved to be paramount to make a correct decision to treat patients suffering from cardiac disease. OBJECTIVE: The current study aims to elucidate the two-way fluid-structure interaction (FSI) analysis of the blood flow and the effect of stenosis on hemodynamic parameters. METHODS: A patient-specific 3D model of the left coronary artery was constructed based on computed tomography (CT) images. The blood is assumed to be incompressible, homogenous, and behaves as Non-Newtonian, while the artery is considered as a nonlinear elastic, anisotropic, and incompressible material. Pulsatile flow conditions were applied at the boundary. Two-way coupled FSI modeling approach was used between fluid and solid domain. The hemodynamic parameters such as the pressure, velocity streamline, and wall shear stress were analyzed in the fluid domain and the solid domain deformation. RESULTS: The simulated results reveal that pressure drop exists in the vicinity of stenosis and a recirculation region after the stenosis. It was noted that stenosis leads to high wall stress. The results also demonstrate an overestimation of wall shear stress and velocity in the rigid wall CFD model compared to the FSI model.

Fluid–structure interaction simulation of aortic blood flow

2011 ◽  
Vol 43 (1) ◽  
pp. 46-57 ◽  
Author(s):  
Paolo Crosetto ◽  
Philippe Reymond ◽  
Simone Deparis ◽  
Dimitrios Kontaxakis ◽  
Nikolaos Stergiopulos ◽  
...  
Keyword(s):  
Blood Flow ◽  
Fluid Structure Interaction ◽  
Aortic Blood Flow ◽  
Fluid Structure ◽  
Structure Interaction ◽  
Aortic Blood ◽  
Interaction Simulation

scholarly journals Three-dimensional multi-scale model of deformable platelets adhesion to vessel wall in blood flow

2014 ◽  
Vol 372 (2021) ◽  
pp. 20130380 ◽  
Author(s):  
Ziheng Wu ◽  
Zhiliang Xu ◽  
Oleg Kim ◽  
Mark Alber
Keyword(s):  
Blood Flow ◽  
Blood Vessel ◽  
Vessel Wall ◽  
Platelet Adhesion ◽  
Three Dimensional ◽  
Clot Formation ◽  
Scale Model ◽  
Injury Site ◽  
Platelet Receptors ◽  
Multi Scale

When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet–platelet adhesion, tethering and rolling on the injured endothelium is a critical initial step in blood clot formation. A novel three-dimensional multi-scale model is introduced and used in this paper to simulate receptor-mediated adhesion of deformable platelets at the site of vascular injury under different shear rates of blood flow. The novelty of the model is based on a new approach of coupling submodels at three biological scales crucial for the early clot formation: novel hybrid cell membrane submodel to represent physiological elastic properties of a platelet, stochastic receptor–ligand binding submodel to describe cell adhesion kinetics and lattice Boltzmann submodel for simulating blood flow. The model implementation on the GPU cluster significantly improved simulation performance. Predictive model simulations revealed that platelet deformation, interactions between platelets in the vicinity of the vessel wall as well as the number of functional GPIb α platelet receptors played significant roles in platelet adhesion to the injury site. Variation of the number of functional GPIb α platelet receptors as well as changes of platelet stiffness can represent effects of specific drugs reducing or enhancing platelet activity. Therefore, predictive simulations can improve the search for new drug targets and help to make treatment of thrombosis patient-specific.

Increased cardiac output and microvascular blood flow during mild hemoconcentration in hamster window model

2006 ◽  
Vol 291 (1) ◽  
pp. H310-H317 ◽  
Author(s):  
Judith Martini ◽  
Amy G. Tsai ◽  
Pedro Cabrales ◽  
Paul C. Johnson ◽  
Marcos Intaglietta
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Shear Stress ◽  
Cardiac Output ◽  
Cardiac Index ◽  
Systemic Blood Pressure ◽  
Second Order ◽  
Microvascular Blood Flow ◽  
Packed Red Blood Cells ◽  
Order Polynomial

The effect of small hematocrit (Hct) increases on cardiac index (cardiac output/body wt) and oxygen release to the microcirculation was investigated in the awake hamster window chamber model by means of exchange transfusions of homologous packed red blood cells. Increasing Hct between 8 and 13% from baseline increased cardiac index by 5–31% from baseline ( P < 0.05) and significantly lowered systemic blood pressure ( P < 0.05). The relationship between Hct and cardiac index is described by a second-order polynomial ( R2 = 0.84; P < 0.05) showing that Hct increases up to 20% from baseline increase cardiac index, whereas increases over 20% from baseline decrease cardiac index. Combining this data with measurements of blood pressure allowed to determine total peripheral vascular resistance, which was a minimum at 8–13% Hct increase and was described by a second-order polynomial ( R2 = 0.83; P < 0.05). Oxygen measurements in arterioles, venules, and the tissue at 8–13% Hct increase were identical to control; thus, as a consequence of increased flow and oxygen-carrying capacity, oxygen delivery and extraction increased, but the change was not statistically significant. Previous results with the same model showed that the observed effects are related to shear stress-mediated release of nitric oxide, an effect that should be also present in the heart microcirculation, leading to increased blood flow, myocardial oxygen consumption, and contractility. We conclude that a minimum viscosity level is necessary for generating the shear stress required for maintaining normal cardiovascular function.

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