CFD Challenge: Solutions Using the Spectral Element Solver NEKTAR

Author(s):  
Yue Yu ◽  
Hyoungsu Baek ◽  
George Em Karniadakis

Flow problems in cardiovascular mechanics involve complex geometries and pulsatile flow that may give rise to instabilities, especially in pathological cases. High-order methods are particularly suitable for resolving such unsteady phenomena whereas low-order methods may exhibit excessive dissipation and hence suppress any such physical instabilities. This, for example, is the case for certain type of cerebral aneurysms, see [1], for which we have demonstrated that shear layer instabilities may be triggered even at physiological flow rates, giving rise to audible frequencies in the range of 10Hz to 50 Hz. Similar phenomena may be present in stenotic arteries, where a jet type flow may develop that is also susceptible to temporal instabilities, especially during the decelerating systole.

Author(s):  
Kah-Hoe Tan ◽  
Ramkumar N. Parthasarathy ◽  
M. Cengiz Altan ◽  
David L. Johnson ◽  
R. E. Clinkenbeard

The flow distribution and pressure drop of steady airflow in the human central airways were studied experimentally using an anatomically correct, selective laser sintered (SLS) human tracheobronchial airway model. Measurements were made for tracheal flow rates ranging from 0.1 to 2.67 liters per second, which correspond to normal physiological flow ranges. The mean air velocities at the exit orifices of the airway model were detected by means of a pitot static tube connected to a pressure transducer. The flow rates, the average velocities, and the Reynolds numbers in each branch of the airway model were then computed. In addition, the static pressure difference between the trachea and the airway exits was measured. The experimental measurements were used to determine the relationship between pressure drop and flow rate. The ratio of inlet to total exit area of the model was identified as a significant factor that influenced the pressure drop. The results obtained in the present study will be particularly useful for validating computational studies.


1993 ◽  
Vol 264 (5) ◽  
pp. F837-F844 ◽  
Author(s):  
M. F. Flessner ◽  
M. A. Knepper

Ammonium accumulates in the renal medullas of antidiuretic animals, presumably due to countercurrent multiplication, driven by NH4+ absorption from ascending loops of Henle in the outer and inner medulla. Active absorption of NH4+ occurs in the thick ascending limb (TAL). But the passive transport properties of NH3 in the TAL and the transport of ammonium or HCO3- in the ascending thin limb (ATL) have not been studied in rodents. To investigate the potential role of the ascending limb segments in medullary accumulation of ammonium, we perfused isolated subsegments of the chinchilla ATL and of the rat ATL and TAL. After imposing concentration gradients of total ammonia or total CO2 across ATL subsegments, we found very high rates of transfer of both substances, implying that at physiological flow rates the tubule luminal fluid quickly equilibrates with the interstitium. In the medullary TAL, we found a passive NH4+ permeability of 17 x 10(-5) cm/s but a relatively low NH3 permeability of < 0.003 cm/s. The low NH3 permeability prevents backleak of NH3 when NH4+ is actively transported from the lumen. We conclude that the ATL acts as an equilibrating segment and the TAL has special permeability properties that enhance net ammonium absorption and therefore enhance medullary ammonium accumulation.


2012 ◽  
Vol 303 (8) ◽  
pp. F1151-F1156 ◽  
Author(s):  
Nancy J. Hong ◽  
Jeffrey L. Garvin

We previously showed that luminal flow stimulates thick ascending limb (TAL) superoxide (O2−) production by stretching epithelial cells and increasing NaCl transport, and reported that the major source of flow-induced O2− is NADPH oxidase (Nox). However, the specific Nox isoform involved is unknown. Of the three isoforms expressed in the kidney—Nox1, Nox2, and Nox4—we hypothesized that Nox4 is responsible for flow-induced O2− production in TALs. Measurable flow-induced O2− production at physiological flow rates of 0, 5, 10, and 20 nl/min was 5 ± 1, 9 ± 2, 36 ± 6, and 66 ± 8 AU/s, respectively. RT-PCR detected mRNA for all three Nox isoforms in the TAL. The order of RNA abundance was Nox2 > Nox4 >>> Nox1. Since all three isoforms are expressed in TALs and pharmacological inhibitors are not selective, we used rats transduced with siRNA and knockout mice. Nox4 siRNA knocked down Nox4 mRNA expression by 63 ± 7% but did not reduce Nox1 or Nox2 mRNA. Flow-induced O2− was 18 ± 9 AU/s in TALs transduced with Nox4 siRNA compared with 77 ± 9 AU/s in tubules transduced with scrambled siRNA. Flow-induced O2− was 81 ± 5 AU/s in Nox2 knockout mice compared with 83 ± 13 AU/s in wild-type mice. In TALs transduced with Nox1 siRNA, flow-induced O2− was 82 ± 7 AU/s. We conclude that Nox4 mediates flow-induced O2− production in TALs.


1966 ◽  
Vol 6 (02) ◽  
pp. 87-101 ◽  
Author(s):  
H.H. Rachford

Abstract Numerical solutions of immiscible flow problems in which dispersive effects of capillarity are dominated by convection require excessively fine grid spacing with attendant high computing costs. The use of coarser spacing reduces cost but often produces oscillation or undue dispersion associated with displacement fronts. A numerical formulation is proposed here which should be applicable to two - dimensional flow problems. It is in part analogous to an approach previously tested for miscible systems. The convective transport is approximated using a change of variables to yield a coordinate system moving approximately with the local characteristic velocity. The capillarity- induced dispersive terms in the differential system describing the process are approximated with respect to a fixed coordinate system by the usual implicit formulation. One-dimensional tests of the procedure yielded results in which the saturation profiles tended smoothly to the zero-capillary pressure solution as the ratio of viscous to capillary forces was successively increased in a sequence of calculations. This contrasted favorably with solutions by other numerical procedures which would require attendant grid refinements to approach the zero capillary pressure results. INTRODUCTION Numerical solution of displacement problems has until recently relied on applying methods developed primarily for transient heat-flow problems. Such problems are classified as parabolic in type, and where the heat transport is purely by diffusion their solutions are characterized by a high degree of smoothness. It is not surprising, therefore, that for approximating these solutions available finite difference methods are quite adequate. In flow problems the transport is partly by diffusion, partly by convection or flow. Although the problem remains of parabolic type because the dispersive effects of capillary forces or diffusion play some role in every displacement, at high flow rates the problem is dominated by convection, and solutions tend toward those of equations of the hyperbolic type. Solutions of hyperbolic problems are characterized by the translation of fronts, or discontinuities, that may progressively increase in sharpness. Numerical methods for treating parabolic problems become less and less satisfactory as displacement rates increase and the role of dispersion due to concentration or capillary pressure gradients becomes small relative to transport due to flow. In computation the difficulty manifests itself as an error associated with the grid size chosen.1-6 In summary, if the heat-flow type approximations are to include the terms arising due to convection, one of several choices may be made:an upstream (to the direction of flow) approximation for the convection terms may be used;a centered-in-distance (CID) approximation may be used; ora recently developed approximation based on the theory of oscillation matrices may be chosen.6 The last appears to have significant promise for one-dimensional flow problems; its extendibility to two or three dimensions is an open question. In either of the first two approaches, a suitably small ratio of v?x/D must be maintained, where v is the velocity, ?x is the grid spacing and D the effective dispersivity in the direction of flow. In the first choice, the approximation of the convective part is only first-order correct and errors introduced appear as a numerically induced dispersivity of magnitude proportional to v?x. In the CID choice, the approximation can be second - order correct, but the difference formulation fails to satisfy the maximum principle unless a condition on v?x/D is met. Practically, this means that for high flow rates oscillatory solutions may result in the neighborhood of a front unless exceedingly small grid intervals are taken. While the procedure proposed by Stone and Brian4 permits a less severe limitation to be placed on this ratio, ultimately the flow rates increase relative to the dispersivity the oscillation obtains.


2011 ◽  
Vol 39 (6) ◽  
pp. 1643-1653 ◽  
Author(s):  
R. Aidan Jamison ◽  
Stephen Dubsky ◽  
Karen K. W. Siu ◽  
Kerry Hourigan ◽  
Andreas Fouras

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