Realizations of Experimental Hydrocephalus Data Through the Analytical Model of Poroviscoelastic Brain Tissue

2012 ◽  
Author(s):  
Amin Mehrabian ◽  
Younane Abousleiman
Keyword(s):  
Cerebrospinal Fluid ◽  
Rheological Properties ◽  
Brain Tissue ◽  
Analytical Model ◽  
Mechanical Characterization ◽  
Extracellular Fluid ◽  
Fluid Content ◽  
Experimental Hydrocephalus ◽  
Csf Absorption

Despite recent advances in hydro-mechanical characterization of brain tissue [1], existing models remain inadequate due to complexities associated with the brain’s geometry and rheological properties [2] as well as limited knowledge on the mechanisms which control the CerebroSpinal Fluid (CSF) absorption or formation and their impact on the extracellular fluid content changes inside parenchyma [3].

scholarly journals Extracellular fluid, cerebrospinal fluid and plasma biomarkers of axonal and neuronal injury following intracerebral hemorrhage

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lovisa Tobieson ◽  
Henrik Zetterberg ◽  
Kaj Blennow ◽  
Niklas Marklund
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracerebral Hemorrhage ◽  
Brain Tissue ◽  
Single Molecule ◽  
Tissue Injury ◽  
Extracellular Fluid ◽  
Neurofilament Light ◽  
Aβ Peptides ◽  
Post Surgery ◽  
Fluid Compartments

AbstractSpontaneous intracerebral hemorrhage (ICH) is the most devastating form of stroke. To refine treatments, improved understanding of the secondary injury processes is needed. We compared energy metabolic, amyloid and neuroaxonal injury biomarkers in extracellular fluid (ECF) from the perihemorrhagic zone (PHZ) and non-injured (NCX) brain tissue, cerebrospinal fluid (CSF) and plasma. Patients (n = 11; age 61 ± 10 years) undergoing ICH surgery received two microdialysis (MD) catheters, one in PHZ, and one in NCX. ECF was analysed at three time intervals within the first 60 h post- surgery, as were CSF and plasma samples. Amyloid-beta (Aβ) 40 and 42, microtubule associated protein tau (tau), and neurofilament-light (NF-L) were analysed using Single molecule array (Simoa) technology. Median biomarker concentrations were lowest in plasma, higher in ECF and highest in CSF. Biomarker levels varied over time, with different dynamics in the three fluid compartments. In the PHZ, ECF levels of Aβ40 were lower, and tau higher when compared to the NCX. Altered levels of Aβ peptides, NF-L and tau may reflect brain tissue injury following ICH surgery. However, the dynamics of biomarker levels in the different fluid compartments should be considered in the study of pathophysiology or biomarkers in ICH patients.

Dual-porosity poroviscoelasticity and quantitative hydromechanical characterization of the brain tissue with experimental hydrocephalus data

2015 ◽  
Vol 384 ◽  
pp. 19-32 ◽  
Author(s):  
Amin Mehrabian ◽  
Younane N. Abousleiman ◽  
Timothy B. Mapstone ◽  
Christian A. El-Amm
Keyword(s):  
Brain Tissue ◽  
Dual Porosity ◽  
Experimental Hydrocephalus ◽  
The Brain

635 Mechanical Characterization of Porcine Brain Tissue in High-rate Compression

2007 ◽  
Vol 2006.19 (0) ◽  
pp. 452-453
Author(s):  
Atsutaka TAMURA ◽  
Sadayuki HAYASHI ◽  
Isao WATANABE ◽  
Kazuaki NAGAYAMA ◽  
Takeo MATSUMOTO
Keyword(s):  
Brain Tissue ◽  
Mechanical Characterization ◽  
High Rate ◽  
Porcine Brain ◽  
Porcine Brain Tissue

scholarly journals Mechanical Characterization of Human Brain Tissue and Soft Dynamic Gels Exhibiting Electromechanical Neuro‐Mimicry

2019 ◽  
Vol 8 (10) ◽  
pp. 1900068 ◽  
Author(s):  
Anthony Tabet ◽  
Stefan Mommer ◽  
Julian A. Vigil ◽  
Clement Hallou ◽  
Harry Bulstrode ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Mechanical Characterization ◽  
Human Brain Tissue

Mechanical Characterization of an In Vitro Device Designed to Quantitatively Injure Living Brain Tissue

10.1114/1.61 ◽  
1998 ◽  
Vol 26 (3) ◽  
pp. 381-390 ◽  
Author(s):  
Barclay Morrison III ◽  
David F. Meaney ◽  
Tracy K. McIntosh
Keyword(s):  
Brain Tissue ◽  
Mechanical Characterization

scholarly journals Extracellular Fluid, Cerebrospinal Fluid and Plasma Biomarkers of Axonal and Neuronal Injury Following Intracerebral Hemorrhage

2021 ◽  
Author(s):  
Lovisa Tobieson ◽  
Henrik Zetterberg ◽  
Kaj Blennow ◽  
Niklas Marklund
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracerebral Hemorrhage ◽  
Brain Tissue ◽  
Single Molecule ◽  
Tissue Injury ◽  
Extracellular Fluid ◽  
Neurofilament Light ◽  
Aβ Peptides ◽  
Post Surgery ◽  
Fluid Compartments

Abstract Background: Spontaneous intracerebral hemorrhage (ICH) is the most devastating form of stroke. To refine treatments, improved understanding of the secondary injury processes is needed. We compared energy metabolic, amyloid and neuroaxonal injury biomarkers in extracellular fluid (ECF) from the perihemorrhagic zone (PHZ) and non-injured (NCX) brain tissue, cerebrospinal fluid (CSF) and plasma. Method: Patients (n=11, age 61 ± 10 years) undergoing ICH surgery received two microdialysis (MD) catheters, one in PHZ, and one in NCX. ECF was analysed at three time intervals within the first 60 hours post- surgery, as were CSF and plasma samples. Amyloid-beta (Aβ) 40 and 42, microtubule associated protein tau (tau), and neurofilament-light (NF-L) were analysed using Single molecule array (Simoa) technology.Results: Median biomarker concentrations were lowest in plasma, higher in ECF and highest in CSF. Biomarker levels varied over time, with different dynamics in the three fluid compartments. In the PHZ, ECF levels of Aβ40 were lower, and tau higher when compared to the NCX.Conclusion: Altered levels of Aβ peptides, NF-L and tau may reflect brain tissue injury following ICH surgery. However, the different biomarker levels, and their dynamics, in the different fluid compartments should be considered when used to monitor ICH patients.

P2-020: MicroRNA complexity in Alzheimer's disease cerebrospinal fluid, extracellular fluid and brain tissue biopsy

2013 ◽  
Vol 9 ◽  
pp. P351-P352
Author(s):  
Walter Lukiw ◽  
Prerna Dua ◽  
JM Hill ◽  
S Bhattacharjee ◽  
Yuhai Zhao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Brain Tissue ◽  
Extracellular Fluid ◽  
Tissue Biopsy
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