Parameter Correlation in Models of Hyperthermic Cell Death

2011 ◽  
Author(s):  
Neil T. Wright
Keyword(s):  
Cell Death ◽  
Ionizing Radiation ◽  
Mathematical Models ◽  
Environmental Conditions ◽  
First Principle ◽  
Multiple Targets ◽  
Cellular Targets ◽  
Parameter Correlation ◽  
Temperature Ranges ◽  
Definition Of

A number of mathematical models have been developed to predict the survival of cells after heating. Some of these models have been based on first principle arguments, while others have been empirically motivated. Some models have been inspired by analogs of damage to cells by ionizing radiation. Evidence exists for multiple targets leading to cell death, although precise definition of the pathways for the various temperature ranges and environmental conditions remains in question. For reviews of the cellular targets of heating, see [1], [2], or [3].

scholarly journals Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells

Genes ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 925
Author(s):  
Eva-Maria Faulhaber ◽  
Tina Jost ◽  
Julia Symank ◽  
Julian Scheper ◽  
Felix Bürkel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Side Effects ◽  
Ionizing Radiation ◽  
Cell Lines ◽  
Normal Tissue ◽  
Kinase Inhibitors ◽  
Induced Response ◽  
Tumor Control ◽  
Tumor Cell Death

(1) Kinase inhibitors (KI) targeting components of the DNA damage repair pathway are a promising new type of drug. Combining them with ionizing radiation therapy (IR), which is commonly used for treatment of head and neck tumors, could improve tumor control, but could also increase negative side effects on surrounding normal tissue. (2) The effect of KI of the DDR (ATMi: AZD0156; ATRi: VE-822, dual DNA-PKi/mTORi: CC-115) in combination with IR on HPV-positive and HPV-negative HNSCC and healthy skin cells was analyzed. Cell death and cell cycle arrest were determined using flow cytometry. Additionally, clonogenic survival and migration were analyzed. (3) Studied HNSCC cell lines reacted differently to DDRi. An increase in cell death for all of the malignant cells could be observed when combining IR and KI. Healthy fibroblasts were not affected by simultaneous treatment. Migration was partially impaired. Influence on the cell cycle varied between the cell lines and inhibitors; (4) In conclusion, a combination of DDRi with IR could be feasible for patients with HNSCC. Side effects on healthy cells are expected to be limited to normal radiation-induced response. Formation of metastases could be decreased because cell migration is impaired partially. The treatment outcome for HPV-negative tumors tends to be improved by combined treatment.

scholarly journals Fatty Acids Metabolism: The Bridge Between Ferroptosis and Ionizing Radiation

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhu-hui Yuan ◽  
Tong Liu ◽  
Hao Wang ◽  
Li-xiang Xue ◽  
Jun-jie Wang
Keyword(s):  
Fatty Acids ◽  
Cell Death ◽  
Ionizing Radiation ◽  
Cell Fate ◽  
Tumor Response ◽  
Cell Fate Decisions ◽  
Current Review ◽  
Pathway Crosstalk ◽  
Fatty Acids Metabolism ◽  
Molecular Signals

Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or anabolism, is essential for synthesizing biological membranes and delivering molecular signals to induce ferroptotic cell death. The current review focuses on the bistable regulation characteristics of FA metabolism and explains how FA catabolism and anabolism pathway crosstalk harmonize different ionizing radiation-regulated ferroptosis responses, resulting in pivotal cell fate decisions. In summary, targeting key molecules involved in lipid metabolism and ferroptosis may amplify the tumor response to IR.

scholarly journals Categories as Mathematical Models

2018 ◽  
Author(s):  
David I. Spivak
Keyword(s):  
Dynamical Systems ◽  
Mathematical Modelling ◽  
Mathematical Models ◽  
Category Theory ◽  
Vector Spaces ◽  
Mathematical Objects ◽  
Working Definition ◽  
Modelling Framework ◽  
Categorical Models ◽  
Definition Of

Category theory is presented as a mathematical modelling framework that highlights the relationships between objects, rather than the objects in themselves. A working definition of model is given, and several examples of mathematical objects, such as vector spaces, groups, and dynamical systems, are considered as categorical models.

scholarly journals Low-dose ionizing radiation alleviates Aβ42-induced cell death via regulating AKT and p38 pathways in Drosophila Alzheimer's disease models

Biology Open ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. bio036657 ◽  
Author(s):  
Soojin Hwang ◽  
Haemin Jeong ◽  
Eun-Hee Hong ◽  
Hae Mi Joo ◽  
Kyoung Sang Cho ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Death ◽  
Ionizing Radiation ◽  
Low Dose ◽  
Disease Models

scholarly journals Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

2020 ◽  
Vol 8 (1) ◽  
pp. e000337 ◽  
Author(s):  
Lorenzo Galluzzi ◽  
Ilio Vitale ◽  
Sarah Warren ◽  
Sandy Adjemian ◽  
Patrizia Agostinis ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Adaptive Immune Response ◽  
Operational Definition ◽  
Immunogenic Cell Death ◽  
Adaptive Immune ◽  
Regulated Cell Death ◽  
Definition Of

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

Pathways to man for radionuclides released from disposal sites on land

1986 ◽  
Vol 319 (1545) ◽  
pp. 165-176
Keyword(s):  
Mathematical Models ◽  
Environmental Conditions ◽  
Radioactive Wastes ◽  
Paper Briefly ◽  
Exposure Pathways ◽  
Land Disposal ◽  
Radiological Impact ◽  
Far Future

To predict the potential radiological impact on man of the disposal of radioactive wastes it is necessary to identify all the events and processes that could cause releases of radionuclides into the environment, to estimate their probabilities of occurrence and to calculate their consequences, for both individuals and populations. This paper briefly reviews the types of releases that have to be considered for land disposal sites and describes the mathematical models used to calculate rates of transport of radionuclides through the environment and doses to man. The difficulties involved in predicting environmental conditions in the far future are discussed, in the light of the ways in which the results of consequence calculations will be used. Assessments of land disposal of long-lived and highly radioactive wastes are briefly reviewed, with the aim of identifying the most important radionuclides and exposure pathways, and the areas where the models and their databases require improvement.

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