Correlation Between Plaque Composition and Shear Stress Using Three-Dimensional Reconstructed Histology and Computational Fluid Dynamics of Diseased Human Carotid Arteries

2011 ◽  
Author(s):  
Kim van der Heiden ◽  
Harald C. Groen ◽  
Lambert Speelman ◽  
Aad van der Lugt ◽  
Anton F. W. van der Steen ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Shear Stress ◽  
Carotid Arteries ◽  
Three Dimensional ◽  
Plaque Formation ◽  
Plaque Composition ◽  
Atherosclerotic Plaque Formation ◽  
Plaque Destabilization ◽  
The Relationship ◽  
Human Carotid

Wall shear stress (WSS) has been shown to play a crucial role in atherosclerotic plaque formation and progression. Moreover, some recent studies suggest that WSS is also involved in determining plaque composition (Cheng et al., 2006) and plaque destabilization in advanced atherosclerosis (Groen et al., 2007). More detailed studies on the relationship between WSS and plaque composition are needed to confirm those relationships.

Fusion of Histology and Shear Stress Based on In Vivo Images

2009 ◽  
Author(s):  
Harald C. Groen ◽  
Theo van Walsum ◽  
Frank J. H. Gijsen ◽  
Sietske Rozie ◽  
Stefan Klein ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Shear Stress ◽  
Plaque Rupture ◽  
Plaque Composition ◽  
Essential Step ◽  
Histological Processing ◽  
Plaque Destabilization ◽  
The Relationship

Evidence is accumulating for a role of high wall shear stress (WSS) in plaque destabilization, leading to plaque rupture [1–2]. To study this in detail we can use carotid plaques that are removed during surgery. The in vivo WSS distribution can be obtained by combining 3D lumen data, derived from pre-operative CT angiography (CTA) imaging, with computational fluid dynamics. Plaque composition can be studied by means of histological processing. Accurate registration of CT imaging with histology is an essential step to study the relationship between WSS and plaque composition.

Abstract 1635: In Vivo Color Mapping Of Shear Stress Along Coronary Arterial Lumen With Multi-detector Computed Tomography

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Yusaku Fukumoto ◽  
Takafumi Hiro ◽  
Takashi Fujii ◽  
Mitsuyuki Hiromoto ◽  
Masakazu Tanaka ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Shear Stress ◽  
Coronary Artery ◽  
Stress Distribution ◽  
Three Dimensional ◽  
Plaque Formation ◽  
Color Mapping ◽  
Atherosclerotic Plaque Formation ◽  
Multi Detector Computed Tomography

Background and Purpose: Shear stress is one of the important physical factors in the process of atherosclerosis. However, noninvasive and in-vivo visualization of shear stress distribution along the coronary lumen has been technically difficult, because it is not so possible to assess true three-dimensional (3D) geometrical structure as well as local flow profile in coronary artery for each patient. Recent technology of multi-detector computed tomography (MDCT) can provide an accurate representation of 3D architecture of coronary lumen as well as plaque distribution. This study was to develop a noninvasive way of color mapping of shear stress in coronary artery using a 64-row MDCT, and to preliminarily evaluate its clinical feasibility. Methods: Three-dimensional geometric architecture from patients with mild coronary artery disease was first obtained to develop a 3D mesh polygon model of each left and right coronary artery architecture. The mesh data was then used to perform a shear stress color mapping with a computational fluid-dynamical simulation of finite element model. The spatial resolution ( mesh size ) was 0.05 mm 2 . The flow was considered to be a constant laminar one, and the pulsatile motion was neglected. The relationship between shear stress and plaque accumulation was then examined. Results: According to the MDCT, atherosclerotic plaque formation was frequently observed in the distal potion at the first and second curvature of right coronary artery, and in the outer side of the bifurcation of the left anterior descending and the circumflex coronary artery. The colorized mapping of shear stress revealed that shear stress tended to be lower at the site of plaque accumulation within coronary artery. Conclusion: This method of 3D representation of shear stress distribution along coronary lumen with a 64-row MDCT might be useful for assessing the role of shear stress in atherosclerotic plaque formation or its progression / regression.

Shear Stress Modulates Plaque Composition in Human Coronary Arteries In Vivo

2008 ◽  
Author(s):  
Frank Gijsen ◽  
Jolanda Wentzel ◽  
Johan Schuurbiers ◽  
Frits Mastik ◽  
Johannes Schaar ◽  
...  
Keyword(s):  
Shear Stress ◽  
Atherosclerotic Plaques ◽  
Plaque Composition ◽  
Low Shear Stress ◽  
Advanced Stages ◽  
Shear Stress And Strain ◽  
Stress Influences ◽  
The Relationship ◽  
Low Shear

It is well established that atherosclerotic plaques generally develop in low shear stress regions, including curved arterial segments and bifurcations1. Once these plaques intrude into the lumen, the shear stress they are exposed to alters with hitherto unknown consequences. We hypothesize that in the more advanced stages of the disease, shear stress has an important impact on plaque composition in such a way that high shear stress enhances plaque vulnerability through its biological impact on the endothelium2. We investigated this hypothesis previously by studying the relationship between shear stress and strain, a marker for plaque composition, in human coronary arteries3. In this study, we will extend that study by investigating how shear stress influences changes of strain, and thus plaque composition, over a period of 6 months.

Three-Dimensional Reconstruction Of Intravascularly Stented Human Carotid Arteries

2005 ◽  
Author(s):  
K.B. Rankins ◽  
S.D. Ainsworth ◽  
T.M. Sullivan ◽  
J.M. Ochterbeck ◽  
M. LaBerge
Keyword(s):  
Carotid Arteries ◽  
Three Dimensional ◽  
Three Dimensional Reconstruction ◽  
Dimensional Reconstruction ◽  
Human Carotid

scholarly journals INDUCTION OF PERTURBED SHEAR STRESS LEADS TO FOCAL ADVANCED ATHEROSCLEROTIC PLAQUE FORMATION IN TRANSGENIC MINIPIGS WITH HYPERCHOLESTEROLEMIA

2015 ◽  
Vol 65 (10) ◽  
pp. A1927
Author(s):  
Christian Bo Poulsen ◽  
Ryan M. Pedrigi ◽  
Vikram V. Mehta ◽  
Anouk Post ◽  
Nilesh Pareek ◽  
...  
Keyword(s):  
Shear Stress ◽  
Atherosclerotic Plaque ◽  
Plaque Formation ◽  
Atherosclerotic Plaque Formation

scholarly journals Endothelial shear rate, local and regional vascular stiffness in patients in different stages of atherogenesis

2016 ◽  
Vol 15 (3) ◽  
pp. 50-56
Author(s):  
V. V. Genkel ◽  
A. O. Salachenko ◽  
O. A. Alekseeva ◽  
I. I. Shaposhnik
Keyword(s):  
Shear Stress ◽  
Shear Rate ◽  
Carotid Artery ◽  
Common Carotid Artery ◽  
Carotid Arteries ◽  
Vascular Stiffness ◽  
Stiffness Index ◽  
The Common ◽  
Relationship Of ◽  
The Relationship

Introduction and purpose. Endothelial cells are subjected to biomechanical stress produced by the bloodstream and tunica media of the vessel. Vascular stiffness and endothelial shear stress have cooperative effects on the endothelial structure and function. However, the relationship of shear stress and arterial stiffness is still poorly understood. The purpose of the study was to assess the relationship of endothelial shear rate and both local and regional vascular stiffness in patients at different stages of the development of atherosclerosis. Methods. The study included 60 patients, 33 men and 27 women. The average age of patients was 54.8±11.7 years. Regional arterial stiffness was assessed by measurement of the pulse wave velocity in the arteries of elastic and muscular types. Local stiffness of the carotid arteries was characterized by Peterson elastic modulus, Young's modulus, stiffness index β, the deformation of the common carotid artery. Endothelial shear rate was measured at the site of the common carotid artery. Results. Average values of carotid endothelial shear rate were equal to 433±127 s-1. Reduced endothelial shear rate in the carotid arteries was associated with an increased Peterson modulus (r = -0.289; p = 0.025) and the stiffness index β (r = -0.280; p = 0.037), and moreover - with decreasing vascular distensibility (r = 0.288; p = 0.026) and deformation (r = 0.296; p = 0.024). Assessment of the relationship between endothelial shear rate and regional vascular stiffness showed weak statistically significant negative correlation of shear rate and PWVcf (r = -0.367; p = 0.014). Conclusion. In study subjects endothelial shear rate reduction in the area of the common carotid artery was associated with an increased Peterson modulus, stiffness index β, decreasing deformation of carotid arteries and increase in aortic stiffness.

Study on the relationship between plaque composition and shear stress in human coronary arteries in vivo

2006 ◽  
Vol 39 ◽  
pp. S280
Author(s):  
J. Wentzel ◽  
F.J.H. Gijsen ◽  
J.C.H. Schuurbiers ◽  
H.M. Garcia-Garcia ◽  
A.F.W. van der Steen ◽  
...  
Keyword(s):  
Shear Stress ◽  
Coronary Arteries ◽  
Plaque Composition ◽  
The Relationship
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