Bodyweight Apparatus Used to Apply Compression Garments for Lymphedema Patients

2011 ◽  
Author(s):  
David DeRoche ◽  
Zachary Sharp
Keyword(s):  
Radiation Therapy ◽  
Cancer Treatment ◽  
Interstitial Fluid ◽  
Lymphatic System ◽  
Medical Condition ◽  
Circulatory System ◽  
Interstitial Tissue ◽  
Compression Garments ◽  
Affected Area ◽  
System 1

Lymphedema is a medical condition caused by an excess of fluid collecting in the interstitial tissue. When the lymphatic system is functioning normally, the interstitial fluid passes into the lymphatic capillaries, thought the lymphatic ducts, and returns to the circulatory system [1]. If this system is disrupted due to congenital reasons, surgery, or radiation therapy associated with cancer treatment, the fluid is unable to properly drain [2]. This collection of fluid leads to swelling of the affected area, usually the legs or arms (Figure 1).

scholarly journals Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis

2020 ◽  
Vol 40 (4) ◽  
pp. 929-942 ◽  
Author(s):  
Nicolas Tessandier ◽  
Imene Melki ◽  
Nathalie Cloutier ◽  
Isabelle Allaeys ◽  
Adam Miszta ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Extracellular Vesicles ◽  
Lymphatic System ◽  
Circulatory System ◽  
Donor Cell ◽  
Vascular Leakage ◽  
In Vivo Model ◽  
Interstitial Tissue ◽  
Tissue Fluid

Objective: The lymphatic system is a circulatory system that unidirectionally drains the interstitial tissue fluid back to blood circulation. Although lymph is utilized by leukocytes for immune surveillance, it remains inaccessible to platelets and erythrocytes. Activated cells release submicron extracellular vesicles (EV) that transport molecules from the donor cell. In rheumatoid arthritis, EV accumulate in the joint where they can interact with numerous cellular lineages. However, whether EV can exit the inflamed tissue to recirculate is unknown. Here, we investigated whether vascular leakage that occurs during inflammation could favor EV access to the lymphatic system. Approach and Results: Using an in vivo model of autoimmune inflammatory arthritis, we show that there is an influx of platelet EV, but not EV from erythrocytes or leukocytes, in joint-draining lymph. In contrast to blood platelet EV, lymph platelet EV lacked mitochondrial organelles and failed to promote coagulation. Platelet EV influx in lymph was consistent with joint vascular leakage and implicated the fibrinogen receptor α2bβ 3 and platelet-derived serotonin. Conclusions: These findings show that platelets can disseminate their EV in fluid that is inaccessible to platelets and beyond the joint in this disease.

Calcium Regulation in Lymphatic Endothelial Cells Under Flow

2013 ◽  
Author(s):  
Mohammad Jafarnejad ◽  
Walter E. Cromer ◽  
Roland R. Kaunas ◽  
David C. Zawieja ◽  
James E. Moore
Keyword(s):  
Immune Response ◽  
Endothelial Cells ◽  
Interstitial Fluid ◽  
Lymphatic System ◽  
Circulatory System ◽  
Muscle Cells ◽  
Lymphatic Endothelial Cells ◽  
Lipid Uptake ◽  
Unidirectional Flow ◽  
Blood Circulatory System

The lymphatic system collects interstitial fluid and proteins and pumps them back to the blood circulatory system. Additionally, it is important in lipid uptake in the mesentery and immune response. Any failure of the system in pumping lymph results in swelling of tissue and/or organ(s), or lymphedema. The lymphatic system consists of initial lymphatic capillaries and larger collecting vessels. The latter contain tubular regions covered with contracting lymphatic muscle cells, which are separated by bi-leaflet valves to ensure unidirectional flow [1].

Scope of Nanotechnology-based Radiation Therapy and Thermotherapy Methods in Cancer Treatment

2012 ◽  
Vol 12 (8) ◽  
pp. 998-1015 ◽  
Author(s):  
Mohamadreza K. Bakht ◽  
Mahdi Sadeghi ◽  
Milad Pourbaghi-Masouleh ◽  
Claudio Tenreiro
Keyword(s):  
Radiation Therapy ◽  
Cancer Treatment

PH-0439 An innovative strategy in cancer treatment: Proton minibeam radiation therapy

2021 ◽  
Vol 161 ◽  
pp. S338
Author(s):  
T. Schmid ◽  
A. Dombrowsky ◽  
M. Sammer ◽  
J. Reindl ◽  
G. Dollinger ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cancer Treatment ◽  
Innovative Strategy

scholarly journals Research on the Glial–Lymphatic System and Its Relationship With Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Danhua Ding ◽  
Xinyu Wang ◽  
Qianqian Li ◽  
Lanjun Li ◽  
Jun Wu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Severity ◽  
Interstitial Fluid ◽  
Lymphatic System ◽  
Pathological Change ◽  
Vital Role ◽  
Aquaporin 4 ◽  
Β Amyloid ◽  
The Brain

Metabolic waste clearance is essential to maintain body homeostasis, in which the lymphatic system plays a vital role. Conversely, in recent years, studies have identified the glial–lymphatic system in the brain, which primarily comprises the inflow of fluid along the para-arterial space. Aquaporin-4 mediates the convection of interstitial fluid in the brain and outflow along the paravenous space. β-Amyloid deposition is a characteristic pathological change in Alzheimer’s disease, and some studies have found that the glial–lymphatic system plays an important role in its clearance. Thus, the glial–lymphatic system may influence Alzheimer’s disease severity and outcome; therefore, this review summarizes the current and available research on the glial–lymphatic system and Alzheimer’s disease.

LYMPHATIC DELIVERY: CONCEPT, CHALLENGES AND APPLICATIONS

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (08) ◽  
pp. 5-22
Author(s):  
C. R Bora ◽  
◽  
R. H. Prabhu ◽  
V. B. Patravale
Keyword(s):  
Lymphatic System ◽  
New Technology ◽  
Critical Role ◽  
Circulatory System ◽  
Drug Carriers ◽  
Entire Body ◽  
Anatomy And Physiology ◽  
Routes Of Administration ◽  
Lymphatic Delivery ◽  
Diagnostic Outcome

The lymphatic system is an additional circulatory system throughout the entire body. It plays a critical role in the recognition of immune system and response to disease. Lymphatic delivery has attracted a lot of attention for providing preferential chemotherapy and enhancing bioavailability of drugs that undergo hepatic first-pass metabolism. The anatomy and physiology of the lymphatic system, routes of administration and different physicochemical parameters of drug/carriers are overviewed. There are numerous challenges in targeting drugs and bioactives to specific sites, maintaining the desired action and crossing all the physiological barriers. Lymphatic delivery for various diseases employing various nanocarriers emerges as a new technology to provide a better therapeutic and diagnostic outcome.

Pediatric cancer treatment using radiation therapy

2015 ◽  
Vol 4 (4) ◽  
pp. 592
Author(s):  
Narayan Kharel ◽  
Ravinath Pandey
Keyword(s):  
Radiation Therapy ◽  
Cancer Treatment ◽  
Pediatric Cancer
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