Objective Measures Relating Cervical Dysfunction to Clinical Diagnosis and Treatment Effects

Author(s):  
B. Rutledge ◽  
J. Vorro ◽  
L. DeStefano ◽  
T. Francisco ◽  
S. Gorbis ◽  
...  

The majority of musculoskeletal (MSD) impairments in the cervical (neck) region cannot be determined through MRIs or radiographs but are instead diagnosed through a clinical assessment technique using palpation. Palpatory diagnostic techniques are based on range of motion (ROM), tissue textures, quality of motion (smooth, elastic or bone on bone) and symmetry [1]. However, because scientifically accepted objective measures are not yet available to complement a clinical diagnosis, the documentation of the impairment as well as effects of treatment can be challenging. Thus, the purpose of this research was to explore the use of three-dimensional kinematics as a potential tool for relating movement patterns of the head/neck to clinical diagnosis and documenting treatment effects.

1983 ◽  
Vol 105 (3) ◽  
pp. 460-467 ◽  
Author(s):  
B. Ravani ◽  
B. Roth

This paper studies planar motion approximation problems in the context of a kinematic mapping. Since a planar displacement is determined by three parameters, it can be mapped into a point of a three-dimensional space. A (single-degree-of-freedom) planar motion can, therefore, be represented by a space curve in the space of the mapping and the problem of motion approximation becomes a curve fitting problem in this space. A mapping introduced by Blaschke is used and a general theory for planar motion approximation is developed. The theory is then applied to dimensional synthesis of four-link mechanisms. Furthermore, since the structural error (i.e., the quality of motion approximation) is dependent on the closeness of the fit in the space of the mapping, a general algebraic theory for determining closest fits to points in this space is developed. The theory is illustrated by a numerical example.


2005 ◽  
Vol 09 (01) ◽  
pp. 1-7 ◽  
Author(s):  
Ee-Chon Teo ◽  
Qing-Hang Zhang ◽  
Hong-Wan Ng

A detailed three-dimensional head-neck (C0–C7) finite element (FE) model developed previously based on the actual geometry of a cadaveric specimen was used to characterize the whiplash phenomenon of the head-neck region during rear-end collision. A maximum rear impact pulse of 8.5 G of acceleration was applied to C7. The effects of a headrest on the responses of head-neck complex were also discussed. The study demonstrates the effectiveness of the current C0–C7 FE model in characterizing the gross responses of human cervical spine under whiplash. The results showed that during whiplash, the lower cervical levels, especially the C6–C7, experience hyperextension in the early phase of acceleration. The whole cervical spine is at risk of extension injuries rather than flexion injuries in whiplash. The use of a proper headrest can effectively reduce the cervical spine from extension injury during the acceleration phase of cervical spine in whiplash.


Author(s):  
S. Khadpe ◽  
R. Faryniak

The Scanning Electron Microscope (SEM) is an important tool in Thick Film Hybrid Microcircuits Manufacturing because of its large depth of focus and three dimensional capability. This paper discusses some of the important areas in which the SEM is used to monitor process control and component failure modes during the various stages of manufacture of a typical hybrid microcircuit.Figure 1 shows a thick film hybrid microcircuit used in a Motorola Paging Receiver. The circuit consists of thick film resistors and conductors screened and fired on a ceramic (aluminum oxide) substrate. Two integrated circuit dice are bonded to the conductors by means of conductive epoxy and electrical connections from each integrated circuit to the substrate are made by ultrasonically bonding 1 mil aluminum wires from the die pads to appropriate conductor pads on the substrate. In addition to the integrated circuits and the resistors, the circuit includes seven chip capacitors soldered onto the substrate. Some of the important considerations involved in the selection and reliability aspects of the hybrid circuit components are: (a) the quality of the substrate; (b) the surface structure of the thick film conductors; (c) the metallization characteristics of the integrated circuit; and (d) the quality of the wire bond interconnections.


Author(s):  
B. Carragher ◽  
M. Whittaker

Techniques for three-dimensional reconstruction of macromolecular complexes from electron micrographs have been successfully used for many years. These include methods which take advantage of the natural symmetry properties of the structure (for example helical or icosahedral) as well as those that use single axis or other tilting geometries to reconstruct from a set of projection images. These techniques have traditionally relied on a very experienced operator to manually perform the often numerous and time consuming steps required to obtain the final reconstruction. While the guidance and oversight of an experienced and critical operator will always be an essential component of these techniques, recent advances in computer technology, microprocessor controlled microscopes and the availability of high quality CCD cameras have provided the means to automate many of the individual steps.During the acquisition of data automation provides benefits not only in terms of convenience and time saving but also in circumstances where manual procedures limit the quality of the final reconstruction.


Author(s):  
Tong Wensheng ◽  
Lu Lianhuang ◽  
Zhang Zhijun

This is a combined study of two diffirent branches, photogrammetry and morphology of blood cells. The three dimensional quantitative analysis of erythrocytes using SEMP technique, electron computation technique and photogrammetry theory has made it possible to push the study of mophology of blood cells from LM, TEM, SEM to a higher stage, that of SEM P. A new path has been broken for deeply study of morphology of blood cells.In medical view, the abnormality of the quality and quantity of erythrocytes is one of the important changes of blood disease. It shows the abnormal blood—making function of the human body. Therefore, the study of the change of shape on erythrocytes is the indispensable and important basis of reference in the clinical diagnosis and research of blood disease.The erythrocytes of one normal person, three PNH Patients and one AA patient were used in this experiment. This research determines the following items: Height;Length of two axes (long and short), ratio; Crevice in depth and width of cell membrane; Circumference of erythrocytes; Isoline map of erythrocytes; Section map of erythrocytes.


1990 ◽  
Vol 18 (4) ◽  
pp. 216-235 ◽  
Author(s):  
J. De Eskinazi ◽  
K. Ishihara ◽  
H. Volk ◽  
T. C. Warholic

Abstract The paper describes the intention of the authors to determine whether it is possible to predict relative belt edge endurance for radial passenger car tires using the finite element method. Three groups of tires with different belt edge configurations were tested on a fleet test in an attempt to validate predictions from the finite element results. A two-dimensional, axisymmetric finite element analysis was first used to determine if the results from such an analysis, with emphasis on the shear deformations between the belts, could be used to predict a relative ranking for belt edge endurance. It is shown that such an analysis can lead to erroneous conclusions. A three-dimensional analysis in which tires are modeled under free rotation and static vertical loading was performed next. This approach resulted in an improvement in the quality of the correlations. The differences in the predicted values of various stress analysis parameters for the three belt edge configurations are studied and their implication on predicting belt edge endurance is discussed.


Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 618
Author(s):  
Giuseppe Damiano ◽  
Vincenzo Davide Palumbo ◽  
Salvatore Fazzotta ◽  
Francesco Curione ◽  
Giulia Lo Monte ◽  
...  

Airway cancers have been increasing in recent years. Tracheal resection is commonly performed during surgery and is burdened from post-operative complications severely affecting quality of life. Tracheal resection is usually carried out in primary tracheal tumors or other neoplasms of the neck region. Regenerative medicine for tracheal replacement using bio-prosthesis is under current research. In recent years, attempts were made to replace and transplant human cadaver trachea. An effective vascular supply is fundamental for a successful tracheal transplantation. The use of biological scaffolds derived from decellularized tissues has the advantage of a three-dimensional structure based on the native extracellular matrix promoting the perfusion, vascularization, and differentiation of the seeded cell typologies. By appropriately modulating some experimental parameters, it is possible to change the characteristics of the surface. The obtained membranes could theoretically be affixed to a decellularized tissue, but, in practice, it needs to ensure adhesion to the biological substrate and/or glue adhesion with biocompatible glues. It is also known that many of the biocompatible glues can be toxic or poorly tolerated and induce inflammatory phenomena or rejection. In tissue and organ transplants, decellularized tissues must not produce adverse immunological reactions and lead to rejection phenomena; at the same time, the transplant tissue must retain the mechanical properties of the original tissue. This review describes the attempts so far developed and the current lines of research in the field of tracheal replacement.


Author(s):  
Radhika Theagarajan ◽  
Shubham Nimbkar ◽  
Jeyan Arthur Moses ◽  
Chinnaswamy Anandharamakrishnan

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1173
Author(s):  
Paolo Bellassi ◽  
Gabriele Rocchetti ◽  
Lorenzo Morelli ◽  
Biancamaria Senizza ◽  
Luigi Lucini ◽  
...  

Pseudomonas fluorescens is a psychrotrophic species associated with milk spoilage because of its lipolytic and proteolytic activities. Consequently, monitoring P. fluorescens or its antecedent activity in milk is critical to preventing quality defects of the product and minimizing food waste. Therefore, in this study, untargeted metabolomics and peptidomics were used to identify the changes in milk related to P. fluorescens activity by simulating the low-temperature conditions usually found in milk during the cold chain. Both unsupervised and supervised multivariate statistical approaches showed a clear effect caused by the P. fluorescens inoculation on milk samples. Our results showed that the levels of phosphatidylglycerophosphates and glycerophospholipids were directly related to the level of contamination. In addition, our metabolomic approach allowed us to detect lipid and protein degradation products that were directly correlated with the degradative metabolism of P. fluorescens. Peptidomics corroborated the proteolytic propensity of P. fluorescens-contaminated milk, but with lower sensitivity. The results obtained from this study provide insights into the alterations related to P. fluorescens 39 contamination, both pre and post heat treatment. This approach could represent a potential tool to retrospectively understand the actual quality of milk under cold chain storage conditions, either before or after heat treatments.


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