Using MicroCT Imaging to Quantify Heat Generation Distribution Induced by Magnetic Nanoparticles

2010 ◽  
Author(s):  
Anilchandra Attaluri ◽  
Ronghui Ma ◽  
Liang Zhu
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Heat Generation ◽  
Surgical Procedures ◽  
Targeted Delivery ◽  
Magnetic Particles ◽  
Attractive Alternative ◽  
Cancer Treatments ◽  
The Past ◽  
Microct Imaging

In the past decade, there have been renewed interests in using magnetic nanoparticles as heating agents when subjected to an alternating magnetic field in cancer treatments. Due to the technical advancement in manufacturing nano-sized magnetic particles, nanoparticle hyperthermia has emerged as an attractive alternative to costly and risky surgical procedures because of its few associated complications and targeted delivery of thermal energy to the tumor.

Targeting Magnetic Nanoparticles in High Magnetic Fields for Drug Delivery Purposes

2004 ◽  
Vol 820 ◽  
Author(s):  
Ramazan Asmatulu ◽  
Richard.O. Claus ◽  
Judy S. Riffle ◽  
Michael Zalich
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Magnetic Particles ◽  
Guidance System ◽  
Test Results ◽  
Test Parameters ◽  
Magnetic Guidance ◽  
The Magnetic Field

AbstractBiodegradable magnetic nanoparticles were synthesized using Poly(L-Lactic Acid) and magnetite nanoparticles (∼14 nm) at different dosages, and then these nanaoparticles (nanocomposites) and pure magnetic particles were targeted in external magnetic fields by changing the test parameters. The magnetic field test results showed that magnetic saturation, fluid speed, magnetic field distance and particle size were extremely effective for a magnetic guidance system that is needed for an effective drug delivery approach. Thus, it is assumed that such nanoparticles can carry drugs (chemotherapy) to be able to cure cancer tumors as well as many other diseases.

scholarly journals Magnetic Nanoparticles of Chitosan for Targeted Delivery System of Plasmids to the Lungs

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Cynthia Aracely Alvizo Báez ◽  
Itza Eloisa Luna Cruz ◽  
Maria Cristina Rodríguez Padilla ◽  
Juan Manuel Alcocer González
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Retention Rate ◽  
Chitosan Nanoparticles ◽  
Luciferase Reporter ◽  
Luciferase Reporter Gene ◽  
Intratracheal Administration ◽  
B16f10 Cells

One of the major problems of gene therapy is the efficient, specific, and targeted delivery as well as the safety of the materials used in such systems. The specific targeted delivery of genes to the lung offers the possibility to treat a variety of specific diseases. We developed chitosan nanoparticles with the plasmid pCEM-Luc, which contains a promoter activated by magnetic field. Nanoparticles of 200–250 nm obtained by ionic gelation with a 99% retention rate were transfected in B16F10 cells andin vivoin the lungs of Balb/c mice by intratracheal administration. We observed that an external magnetic field increased the expression of the luciferase reporter gene in B16F10 cells transfected with magnetic nanoparticles and in homogenized lungs of mice which determined differences in levels of expression between different regions of the lungs (apical or distal and left or right). The highest levels of luciferase activity were observed in the apical left region. The magnetic nanoparticles prove an efficient delivery system toin vitrotransfection of cells and lung tissue.

Non-Equilibrium Magnetization of a Dilute Suspension of Magnetic Particles

2009 ◽  
Vol 152-153 ◽  
pp. 167-170 ◽  
Author(s):  
Alexander Tyatyushkin
Keyword(s):  
Magnetic Field ◽  
Magnetic Susceptibility ◽  
Heat Generation ◽  
Applied Magnetic Field ◽  
Single Particle ◽  
Uniform Magnetic Field ◽  
Magnetic Particles ◽  
Equilibrium Magnetization ◽  
Dilute Suspension ◽  
Generation Power

A suspension of magnetic particles in a viscous liquid magnetized in an alternating uniform magnetic field is theoretically studied. The suspension is regarded as so dilute that interaction of a single particle with the applied magnetic field can be considered without taking into account the influence of other particles. The complex magnetic susceptibility of the suspension is found as a function of the frequency of the applied magnetic field. The heat generation power density averaged over the period of the oscillations is calculated.

scholarly journals Ultrasonic Studies of Emulsion Stability in the Presence of Magnetic Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
A. Józefczak ◽  
R. Wlazło
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Acoustic Waves ◽  
Magnetic Particles ◽  
Emulsion Stability ◽  
High Energy ◽  
Pickering Emulsions ◽  
Ultrasound Waves ◽  
Acoustic Study ◽  
Magnetite Particles

Pickering emulsions are made of solid particle-stabilized droplets suspended in an immiscible continuous liquid phase. A magnetic emulsion can be obtained using magnetic particles. Solid magnetic nanoparticles are adsorbed strongly at the oil-water interface and are able to stabilize emulsions of oil and water. In this work emulsions stabilized by magnetite nanoparticles were obtained using high-energy ultrasound waves and a cavitation mechanism and, next, their stability in time was tested by means of acoustic waves with a low energy, without affecting the structure. An acoustic study showed high stability in time of magnetic emulsions stabilized by magnetite particles. The study also showed a strong influence of an external magnetic field, which can lead to changes of the emulsion properties. It is possible to control Pickering emulsion stability with the help of an external stimulus—a magnetic field.

Stochastic Dynamics of Magnetic Nanoparticles at Finite Temperatures

2010 ◽  
Vol 168-169 ◽  
pp. 105-108
Author(s):  
V.V. Zverev ◽  
G.A. Usachev
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Numerical Simulations ◽  
Magnetic Particles ◽  
Stochastic Dynamics ◽  
Thermal Fluctuations ◽  
Spatial Complexity ◽  
Temporal And Spatial

We consider unstable motion in small magnetic particles, driven by an external magnetic field and influenced by thermal fluctuations. Our studies demonstrate both temporal and spatial complexity of the dynamics in this system. The results are obtained using numerical simulations of the Landau-Lifshitz-Gilbert equations.

Size Dependent Heat Generation of Magnetic Nanoparticles Under AC Magnetic Field for Cancer Therapy

2010 ◽  
pp. 415-421 ◽  
Author(s):  
Jun Motoyama ◽  
Toshiyuki Hakata ◽  
Ryuji Kato ◽  
Noriyuki Yamashita ◽  
Tomio Morino ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Heat Generation ◽  
Ac Magnetic Field ◽  
Size Dependent

Targeted delivery of β-glucosidase-loaded magnetic nanoparticles: effect of external magnetic field duration and intensity

Nanomedicine ◽  
2020 ◽  
Vol 15 (21) ◽  
pp. 2029-2040
Author(s):  
Jie Zhou ◽  
Jing Hou ◽  
Yunlong Liu ◽  
Jun Rao
Keyword(s):  
Magnetic Field ◽  
Enzyme Activity ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Targeted Delivery ◽  
Tumor Tissue ◽  
Iron Concentration ◽  
Blue Staining ◽  
Activity Measurement ◽  
Resonance Detection

Aim: The effect of applied magnetic field duration and intensity on the delivery of β-glucosidase-loaded magnetic nanoparticles was evaluated. Materials & methods: The prepared β-glucosidase-loaded magnetic nanoparticles were targeted to subcutaneous tumors with an external magnetic field. Iron concentration and enzyme activity in tumor tissue were analyzed via electron spin resonance detection, Prussian blue staining and enzyme activity measurement. Results: The increase in magnetic nanoparticles quantity and enzyme activity in tumor tissue was not synchronous with the magnetic targeting duration. In addition, accumulation of magnetic nanoparticles and the increase in enzyme activity were not synchronous with the magnetic field intensity. Conclusion: The results suggested that appropriate magnetic field conditions should be considered for targeted delivery of bioactivity proteins based on magnetic nanoparticles.

scholarly journals Experimental investigation on heat transfer rate of Co–Mn ferrofluids in external magnetic field

2016 ◽  
Vol 34 (2) ◽  
pp. 427-436 ◽  
Author(s):  
M. Margabandhu ◽  
S. Sendhilnathan ◽  
S. Senthilkumar ◽  
K. Hirthna
Keyword(s):  
Magnetic Field ◽  
Heat Transfer ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Heat Transfer Rate ◽  
Transfer Rate ◽  
Magnetic Particles ◽  
Transformer Oil ◽  
Carrier Fluid ◽  
Magnetic Nanofluids

AbstractManganese substituted cobalt ferrite (Co1–xMnxFe2O4 with x = 0, 0.3, 0.5, 0.7 and 1) nanopowders were synthesized by chemical coprecipitation method. The synthesized magnetic nanoparticles were investigated by various characterization techniques, such as X-ray diffraction (XRD), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM) and thermogravimetric and differential thermal analysis (TG/DTA). The XRD results confirmed the presence of cubic spinel structure of the prepared powders and the average crystallite size of magnetic particles ranging from 23 to 45 nm. The VSM results showed that the magnetic properties varied with an increase in substituted manganese while SEM analysis showed the change in the morphology of obtained magnetic nanoparticles. The TG/DTA analysis indicated the formation of crystalline structure of the synthesized samples. The heat transfer rate was measured in specially prepared magnetic nanofluids (nanoparticles dispersed in carrier fluid transformer oil) as a function of time and temperature in presence of external magnetic fields. The experimental analysis indicated enhanced heat transfer rate of the magnetic nanofluids which depended upon the strength of external magnetic field and chemical composition.

scholarly journals Investigation of Magnetic Nanoparticle Motion under a Gradient Magnetic Field by an Electromagnet

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Weizhong Wei ◽  
Zhen Wang
Keyword(s):  
Magnetic Field ◽  
Finite Element ◽  
Electromagnetic Field ◽  
Magnetic Nanoparticles ◽  
Particle Motion ◽  
Biomedical Applications ◽  
Magnetic Nanoparticle ◽  
Magnetic Particles ◽  
Magnetic Force ◽  
Gradient Magnetic Field

Finite element numerical simulations were carried out in 2D geometry to calculate the magnetic force on magnetic nanoparticles under a specially fabricated electromagnet. The particle motion was modeled by a system of ordinary differential equations. The snapshots of trajectories of 4000 MNPs with and without magnetic field were analyzed and qualitatively found to be in agreement with camera visualizations of MNP movement in a container. The results of the analysis could be helpful for the design of electromagnetic field and motion analysis of magnetic particles for the delivery of magnetic materials in biomedical applications.

scholarly journals Synthesis of Magnetic Ferrite Nanoparticles with High Hyperthermia Performance via a Controlled Co-Precipitation Method

Nanomaterials ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 1176 ◽  
Author(s):  
Darwish ◽  
Kim ◽  
Lee ◽  
Ryu ◽  
Lee ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Metal Content ◽  
Cobalt Ferrite ◽  
Ferrite Nanoparticles ◽  
Precipitation Method ◽  
Maximum Temperature ◽  
Cancer Treatments ◽  
Prepared Nanoparticles ◽  
Co Precipitation

Magnetic nanoparticles (MNPs) that exhibit high specific loss power (SLP) at lower metal content are highly desirable for hyperthermia applications. The conventional co-precipitation process has been widely employed for the synthesis of magnetic nanoparticles. However, their hyperthermia performance is often insufficient, which is considered as the main challenge to the development of practicable cancer treatments. In particular, ferrite MNPs have unique properties, such as a strong magnetocrystalline anisotropy, high coercivity, and moderate saturation magnetization, however their hyperthermia performance needs to be further improved. In this study, cobalt ferrite (CoFe2O4) and zinc cobalt ferrite nanoparticles (ZnCoFe2O4) were prepared to achieve high SLP values by modifying the conventional co-precipitation method. Our modified method, which allows for precursor material compositions (molar ratio of Fe+3:Fe+2:Co+2/Zn+2 of 3:2:1), is a simple, environmentally friendly, and low temperature process carried out in air at a maximum temperature of 60 °C, without the need for oxidizing or coating agents. The particles produced were characterized using multiple techniques, such as X-ray diffraction (XRD), dynamic light scattering (DLS), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV–Vis spectroscopy), and a vibrating sample magnetometer (VSM). SLP values of the prepared nanoparticles were carefully evaluated as a function of time, magnetic field strength (30, 40, and 50 kA m−1), and the viscosity of the medium (water and glycerol), and compared to commercial magnetic nanoparticle materials under the same conditions. The cytotoxicity of the prepared nanoparticles by in vitro culture with NIH-3T3 fibroblasts exhibited good cytocompatibility up to 0.5 mg/mL. The safety limit of magnetic field parameters for SLP was tested. It did not exceed the 5 × 109 Am−1 s−1 threshold. A saturation temperature of 45 °C could be achieved. These nanoparticles, with minimal metal content, can ideally be used for in vivo hyperthermia applications, such as cancer treatments.

Sign in / Sign up

Export Citation Format

Share Document