Measurement of Coronary Artery Wall Strain In Situ Using IVUS

2007 ◽  
Author(s):  
Yun Liang ◽  
Hui Zhu ◽  
Morton H. Friedman
Keyword(s):  
Plaque Rupture ◽  
Radial Strain ◽  
Estimation Method ◽  
Pressure Change ◽  
Cross Sectional ◽  
Strain Estimation ◽  
2D Strain ◽  
Rf Signals ◽  
Ivus Image ◽  
Atherosclerotic Plaque Rupture

Atherosclerotic plaque rupture is the leading cause of mortality in cardiovascular diseases. Studying biomechanics of plaque provides important insights into its vulnerability, since a plaque behaves consistently with its underlying contents. Arterial wall strain in response to luminal pressure change is such a measurable quantity. Intravascular ultrasound (IVUS) imaging is a wildly available clinical technique providing real time cross-sectional images of the vessel wall and plaque morphometry. IVUS elastography has been used to measure the radial strain through correlation analysis of the IVUS radiofrequency (RF) signals. We have developed a strain estimation method based on IVUS image registration. Our method has the ability to overcome nonlinear tissue deformation and measure 2D strain.

Coronary Artery Wall Strain Estimation From Clinical IVUS Images

2007 ◽  
Author(s):  
Yun Liang ◽  
Hui Zhu ◽  
Thomas Gehrig ◽  
Morton H. Friedman
Keyword(s):  
Arterial Wall ◽  
Mechanical Response ◽  
Plaque Rupture ◽  
Radial Strain ◽  
Estimation Method ◽  
Pressure Change ◽  
Tissue Deformation ◽  
Cross Sectional ◽  
Strain Estimation

Atherosclerotic plaque rupture is responsible for the majority of acute coronary syndromes and myocardial infarctions. Intravascular ultrasound (IVUS) imaging is a widely available clinical technique providing real time cross-sectional images of the vessel wall and plaque morphometry. However, IVUS echo images have limited ability to predict the vulnerability of the plaque. The mechanical behavior of the plaque is consistent with its underlying components, suggesting that measurements of plaque mechanical response can be used to assess the likelihood of plaque rupture [1]. Arterial wall strain in response to luminal pressure change is such a measurable quantity. IVUS elastography has been developed to measure the radial strain through correlation analysis of the IVUS radiofrequency (RF) signal [2]. Due to the movements of IVUS catheter caused by cardiac motion and the nonlinearity of tissue deformation, reliable strain is obtained by elastography only when the tissue motion is aligned with the RF direction and the RF traces correspond to the same axial location. This is difficult to achieve in vivo. We have developed a strain estimation method based on IVUS image registration. This 2D processing method has the ability to overcome in-plane catheter movement and heterogeneous tissue deformation, thereby increasing its accuracy. Using retrospectively retrieved cardiac phase information, we propose a practical method to estimate cross-sectional coronary arterial wall strain distribution from clinically acquired images during a conventional IVUS procedure.

Ferrite-encapsulated nanoparticles with stable photothermal performance for multimodal imaging-guided atherosclerotic plaque neovascularization therapy

2021 ◽  
Author(s):  
Zhuowen Yang ◽  
Jianting Yao ◽  
Jianxin Wang ◽  
Cong Zhang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Multimodal Imaging ◽  
Plaque Rupture ◽  
Pathological Angiogenesis ◽  
Atherosclerotic Plaque Rupture ◽  
Encapsulated Nanoparticles

Pathological angiogenesis is a critical contributor to atherosclerotic plaque rupture. However, there are few effective theranostic strategies to stabilize plaques by suppressing neovascularization. A polymeric nanosystem using 3 nm manganese...

scholarly journals Applicability of Recent Dyslipidemia Guidelines in Clinical Practice

2019 ◽  
Vol 5 (1 (P)) ◽  
pp. 43
Author(s):  
Erwinanto Erwinanto
Keyword(s):  
Myocardial Infarction ◽  
Atherosclerotic Plaque ◽  
Coronary Flow ◽  
Cardiovascular Events ◽  
Ldl Cholesterol ◽  
Plaque Rupture ◽  
Heart Association ◽  
Plaque Stabilization ◽  
Plaque Regression ◽  
Atherosclerotic Plaque Rupture

Atherosclerotic plaque rupture is closely related to acute coronary syndromes.Stabilization of atherosclerotic plaque which slashes plaque rupture is as importantas regression ofplaque size for reducing cardiovascular events. Dyslipidemia therapy targeting to decrease LDL cholesterol reduces cardiovascular events such as acute myocard infarct, stroke, and death which are suggested to be the result of plaque stabilization. Dyslipidemia therapy also regress atherosclerotic plaque into a smaller volume. Plaque regression improves coronary flow responsible for the reduction of myocardial infarction incidence in patients with coronary heart disease (CHD).This paper consists of two parts. The first part discusses the evidence of cardiovascular event reduction with statin. The second part describes dyslipidemia management based on the 2017 Indonesian Heart Association (PERKI) Guideline on the Management of Dyslipidemia

scholarly journals Research Progress on the Relationship between Atherosclerosis and Inflammation

Biomolecules ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 80 ◽  
Author(s):  
Yuhua Zhu ◽  
Xuemei Xian ◽  
Zhenzhen Wang ◽  
Yingchao Bi ◽  
Quangang Chen ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Plaque Rupture ◽  
Chronic Inflammatory Disease ◽  
Research Progress ◽  
Bioactive Lipids ◽  
Inflammatory Signaling ◽  
Vascular Stenosis ◽  
Unstable Atherosclerotic Plaque ◽  
Atherosclerotic Plaque Rupture

Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture, vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute cardiovascular disease. Atherosclerosis-related inflammation is mediated by proinflammatory cytokines, inflammatory signaling pathways, bioactive lipids, and adhesion molecules. This review discusses the effects of inflammation and the systemic inflammatory signaling pathway on atherosclerosis, the role of related signaling pathways in inflammation, the formation of atherosclerosis plaques, and the prospects of treating atherosclerosis by inhibiting inflammation.

scholarly journals Demand Function for Industrial Electricity: Evidence from South Korean Manufacturing Sector

2019 ◽  
Vol 11 (18) ◽  
pp. 5112
Author(s):  
Kim ◽  
Kim ◽  
Yoo
Keyword(s):  
South Korea ◽  
Demand Function ◽  
Manufacturing Sector ◽  
Estimation Method ◽  
Electricity Consumption ◽  
Nationwide Survey ◽  
Economic Benefits ◽  
Manufacturing Firms ◽  
Cross Sectional ◽  
Least Absolute Deviations

Electricity is a crucial input to the industrial production of South Korea. Estimating the demand function for electricity in the manufacturing sector is an important task because electricity consumption in the manufacturing sector accounts for 56.3% of total electricity consumption in South Korea. Thus, this article tries to estimate the demand function for industrial electricity in the manufacturing sector of South Korea using cross-sectional data for analyzing the influence of manufacturing firms’ characteristics. To this end, 946 observations collected from a nationwide survey of manufacturing firms in 2018 are used and analyzed. As a robust approach, the least absolute deviations estimation method is applied to obtaining the demand function. The results show that the price elasticity and the sales amount elasticity of the industrial electricity demand are estimated to be −0.9206 and 0.2568, respectively, which are statistically significant at the 1% level. Furthermore, the economic benefits of industrial electricity consumption are computed to be 1.46 times as great as the price of electricity. The results of this study can be utilized in policy planning, making, and evaluation.

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