Micromechanical Analysis of Tissues: The Effect of Cell Adhesion to Extra Cellular Matrix

2007 ◽  
Author(s):  
N. Abolfathi ◽  
G. Karami ◽  
M. Ziejewski
Keyword(s):  
Mechanical Property ◽  
Cell Adhesion ◽  
Tissue Injury ◽  
Extra Cellular Matrix ◽  
Micromechanical Modeling ◽  
External Loading ◽  
The Matrix ◽  
A Cell ◽  
Cellular Matrix

Modeling of interactions between cell and extra cellular matrix (ECM) is essential in a cell and tissue injury study. Several studies have been conducted to realize the role of mechanical property of a cell and ECM in a tissue exposed to an external loading. In this study we have used a micromechanical approach by assuming two representative volume elements (RVE) with different packing of cell inside the matrix to characterize the mechanical property of the composite formed by the cell and the ECM in a tissue. In the micromechanical modeling procedure, the cell-ECM adhesion will be studied in detail. The results will clarify the role of cell adhesion in load transferring characteristics inside the cell – ECM composite.

The Role of Cytokines in Interactions of Mesenchymal Stem Cells and Breast Cancer Cells

2020 ◽  
Vol 15 ◽  
Author(s):  
Hariharan Jayaraman ◽  
Nalinkanth V. Ghone ◽  
Ranjith Kumaran R ◽  
Himanshu Dashora
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Cell Communication ◽  
Extra Cellular Matrix ◽  
Cytokine Signaling ◽  
Cellular Matrix

: Mesenchymal stem cells because of its high proliferation, differentiation, regenerative capacity, and ease of availability have been a popular choice in cytotherapy. Mesenchymal Stem Cells (MSCs) have a natural tendency to home in a tumor microenvironment and acts against it, owing to the similarity of the latter to an injured tissue environment. Several studies have confirmed the recruitment of MSCs by tumor through various cytokine signaling that brings about phenotypic changes to cancer cells, thereby promoting migration, invasion, and adhesion of cancer cells. The contrasting results on MSCs as a tool for cancer cytotherapy may be due to the complex cell to cell interaction in the tumor microenvironment, which involves various cell types such as cancer cells, immune cells, endothelial cells, and cancer stem cells. Cell to cell communication can be simple or complex and it is transmitted through various cytokines among multiple cell phenotypes, mechano-elasticity of the extra-cellular matrix surrounding the cancer cells, and hypoxic environments. In this article, the role of the extra-cellular matrix proteins and soluble mediators that acts as communicators between mesenchymal stem cells and cancer cells has been reviewed specifically for breast cancer, as it is the leading member of cancer malignancies. The comprehensive information may be beneficial in finding a new combinatorial cytotherapeutic strategy using MSCs by exploiting the cross-talk between mesenchymal stem cells and cancer cells for treating breast cancer.

A NUMERICAL PROOF THAT CERTAIN CELLS FOLLOW THE TRAILS OF THE DIFFUSIONS OF SOME CHEMICALS IN THE EXTRACELLULAR MATRIX

2021 ◽  
pp. 2150027
Author(s):  
İREM ÇAY ◽  
SERDAL PAMUK
Keyword(s):  
Mathematical Model ◽  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Numerical Solutions ◽  
Extra Cellular Matrix ◽  
The Matrix ◽  
Good Agreement ◽  
Cellular Matrix

In this work, we obtain the numerical solutions of a 2D mathematical model of tumor angiogenesis originally presented in [Pamuk S, ÇAY İ, Sazci A, A 2D mathematical model for tumor angiogenesis: The roles of certain cells in the extra cellular matrix, Math Biosci 306:32–48, 2018] to numerically prove that the certain cells, the endothelials (EC), pericytes (PC) and macrophages (MC) follow the trails of the diffusions of some chemicals in the extracellular matrix (ECM) which is, in fact, inhomogeneous. This leads to branching, the sprouting of a new neovessel from an existing vessel. Therefore, anastomosis occurs between these sprouts. In our figures we do see these branching and anastomosis, which show the fact that the cells diffuse according to the structure of the ECM. As a result, one sees that our results are in good agreement with the biological facts about the movements of certain cells in the Matrix.

scholarly journals Potential role of SC1, a cell adhesion molecule, in mammary gland tumors

2008 ◽  
Author(s):  
Kenji Hagimori ◽  
Hidenori Kato ◽  
Keiko Fukuda ◽  
Masaharu Kikuta ◽  
Yasuhiro Tsukamoto ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Mammary Gland ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Potential Role ◽  
Mammary Gland Tumors ◽  
A Cell

Cell adhesion control by ion implantation into extra-cellular matrix

1994 ◽  
Vol 91 (1-4) ◽  
pp. 588-592 ◽  
Author(s):  
Suzuki Yoshiaki ◽  
Kusakabe Masahiro ◽  
Kaibara Makoto ◽  
Iwaki Masaya ◽  
Sasabe Hiroyuki ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ion Implantation ◽  
Extra Cellular Matrix ◽  
Adhesion Control ◽  
Cellular Matrix

scholarly journals Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts

2004 ◽  
Vol 167 (5) ◽  
pp. 973-983 ◽  
Author(s):  
Satoshi Fukumoto ◽  
Takayoshi Kiba ◽  
Bradford Hall ◽  
Noriyuki Iehara ◽  
Takashi Nakamura ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Matrix Protein ◽  
Oral Epithelium ◽  
Enamel Matrix Protein ◽  
Mineralized Tissues ◽  
The Matrix ◽  
A Cell ◽  
Dental Epithelium

Tooth morphogenesis results from reciprocal interactions between oral epithelium and ectomesenchyme culminating in the formation of mineralized tissues, enamel, and dentin. During this process, epithelial cells differentiate into enamel-secreting ameloblasts. Ameloblastin, an enamel matrix protein, is expressed by differentiating ameloblasts. Here, we report the creation of ameloblastin-null mice, which developed severe enamel hypoplasia. In mutant tooth, the dental epithelium differentiated into enamel-secreting ameloblasts, but the cells were detached from the matrix and subsequently lost cell polarity, resumed proliferation, and formed multicell layers. Expression of Msx2, p27, and p75 were deregulated in mutant ameloblasts, the phenotypes of which were reversed to undifferentiated epithelium. We found that recombinant ameloblastin adhered specifically to ameloblasts and inhibited cell proliferation. The mutant mice developed an odontogenic tumor of dental epithelium origin. Thus, ameloblastin is a cell adhesion molecule essential for amelogenesis, and it plays a role in maintaining the differentiation state of secretory stage ameloblasts by binding to ameloblasts and inhibiting proliferation.

Stability and Collapsing Mechanism of Cavitation-Induced Nanobubbles in Simulated Extra-Cellular Matrix (ECM) Near Neuron

2016 ◽  
Author(s):  
Y.-T. Wu ◽  
A. Adnan
Keyword(s):  
Extra Cellular Matrix ◽  
Bubble Collapse ◽  
Experimental Investigations ◽  
Perineuronal Nets ◽  
Neuron Damage ◽  
The Stability ◽  
The Relationship ◽  
Fluid Interaction ◽  
Cellular Matrix

In blast-induced traumatic brain injury, shock waves (SW) play an important role along with cavitation phenomena. Due to the lack of reliable and reproducible experimental investigations, we have a limited understanding of the role of cavitation in brain damage. The present study aims to develop an atomistic simulation model to determine the role of shock-induced impulse and different constituents of the brain’s extra-cellular matrix (ECM) on the formation mechanism, stability and collapsing mechanism of nanobubbles in the ECM. The ECM in the brain can be divided into three major types depending on their location behind the blood-brain barrier, namely (a) the basement membrane (basal lamina), (b) the perineuronal nets and (3) the neural interstitial matrix. In this paper, we have studied the interaction of nanobubbles with bio-molecules of the perineuronal nets. We have chosen this zone of the ECM because we are interested to obtain the role of cavitation bubble collapse in neuron damage. Most biomolecules of perineuronal nets are slender in shape and flexible which is believed to induce special solid-fluid interaction between the fluid domain and the solid domain within the ECM. In addition, perineuronal nets contain a significant number of sodium ions. The relationship between sodium ion and solid-like constituents of perineuronal nets on the stability and the collapsing mechanism of nanobubbles will be discussed.

Cell adhesion control by ion implantation into polymeric materials and extra-cellular matrix

1995 ◽  
Vol 46 (2) ◽  
pp. 263-267 ◽  
Author(s):  
M. Kusakabe ◽  
Y. Suzuki ◽  
M. Kaibara ◽  
M. Iwaki ◽  
H. Sasabe
Keyword(s):  
Cell Adhesion ◽  
Ion Implantation ◽  
Polymeric Materials ◽  
Extra Cellular Matrix ◽  
Adhesion Control ◽  
Cellular Matrix

scholarly journals A Brief History in Cardiac Regeneration, and How the Extra Cellular Matrix May Turn the Tide

2021 ◽  
Vol 8 ◽  
Author(s):  
Atze van der Pol ◽  
Carlijn V. C. Bouten
Keyword(s):  
Current Knowledge ◽  
Cardiac Regeneration ◽  
Stressful Events ◽  
Extra Cellular Matrix ◽  
Myocardial Tissue ◽  
Cell Source ◽  
Cell Sources ◽  
A Cell ◽  
Contractile Tissue ◽  
Cellular Matrix

Tissue homeostasis is perturbed by stressful events, which can lead to organ dysfunction and failure. This is particularly true for the heart, where injury resulting from myocardial infarction or ischemic heart disease can result in a cascading event ultimately ending with the loss of functional myocardial tissue and heart failure. To help reverse this loss of healthy contractile tissue, researchers have spent decades in the hopes of characterizing a cell source capable of regenerating the injured heart. Unfortunately, these strategies have proven to be ineffective. With the goal of truly understanding cardiac regeneration, researchers have focused on the innate regenerative abilities of zebrafish and neonatal mammals. This has led to the realization that although cells play an important role in the repair of the diseased myocardium, inducing cardiac regeneration may instead lie in the composition of the extra cellular milieu, specifically the extra cellular matrix. In this review we will briefly summarize the current knowledge regarding cell sources used for cardiac regenerative approaches, since these have been extensively reviewed elsewhere. More importantly, by revisiting innate cardiac regeneration observed in zebrafish and neonatal mammals, we will stress the importance the extra cellular matrix has on reactivating this potential in the adult myocardium. Finally, we will address how we can harness the ability of the extra cellular matrix to guide cardiac repair thereby setting the stage of next generation regenerative strategies.

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