The Effect of Nonlinear Scleral Properties on Optic Nerve Head Biomechanics

2007 ◽  
Author(s):  
Armin Eilaghi ◽  
Ian A. Sigal ◽  
Christian G. Olesen ◽  
Inka Tertinegg ◽  
John G. Flanagan ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Progressive Damage ◽  
Ocular Diseases ◽  
Glaucomatous Damage ◽  
Elevated Intraocular Pressure ◽  
Biomechanical Factors

Glaucoma is a group of potentially blinding ocular diseases caused by gradual and progressive damage to the optic nerve, and is usually associated with elevated intraocular pressure (IOP) [1]. This damage occurs at the optic nerve head (ONH), the site where the optic nerve axons leave the posterior eye. IOP-related biomechanical factors are hypothesized to play a key role in the pathogenesis of glaucomatous damage [2].

scholarly journals Optic Nerve Head Astrocytes Display Axon-Dependent and -Independent Reactivity in Response to Acutely Elevated Intraocular Pressure

2019 ◽  
Vol 60 (1) ◽  
pp. 312 ◽  
Author(s):  
Shandiz Tehrani ◽  
Lauren Davis ◽  
William O. Cepurna ◽  
R. Katherine Delf ◽  
Diana C. Lozano ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Elevated Intraocular Pressure

scholarly journals An Overview of Glaucoma: Bidirectional Translation between Humans and Pre-Clinical Animal Models

2021 ◽  
Author(s):  
Sophie Pilkinton ◽  
T.J. Hollingsworth ◽  
Brian Jerkins ◽  
Monica M. Jablonski
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Animal Models ◽  
Retinal Ganglion Cells ◽  
Optic Nerve Head ◽  
Ganglion Cells ◽  
Treatment Modalities ◽  
Retinal Ganglion ◽  
Glaucomatous Damage

Glaucoma is a multifactorial, polygenetic disease with a shared outcome of loss of retinal ganglion cells and their axons, which ultimately results in blindness. The most common risk factor of this disease is elevated intraocular pressure (IOP), although many glaucoma patients have IOPs within the normal physiological range. Throughout disease progression, glial cells in the optic nerve head respond to glaucomatous changes, resulting in glial scar formation as a reaction to injury. This chapter overviews glaucoma as it affects humans and the quest to generate animal models of glaucoma so that we can better understand the pathophysiology of this disease and develop targeted therapies to slow or reverse glaucomatous damage. This chapter then reviews treatment modalities of glaucoma. Revealed herein is the lack of non-IOP-related modalities in the treatment of glaucoma. This finding supports the use of animal models in understanding the development of glaucoma pathophysiology and treatments.

scholarly journals Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0167364 ◽  
Author(s):  
Shandiz Tehrani ◽  
Lauren Davis ◽  
William O. Cepurna ◽  
Tiffany E. Choe ◽  
Diana C. Lozano ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Rat Model ◽  
Molecular Response ◽  
Elevated Intraocular Pressure

The Impact of Acutely Elevated Intraocular Pressure on the Porcine Optic Nerve Head

2011 ◽  
Vol 52 (9) ◽  
pp. 6192 ◽  
Author(s):  
Naeem Fatehee ◽  
Paula K. Yu ◽  
William H. Morgan ◽  
Stephen J. Cringle ◽  
Dao-Yi Yu
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Elevated Intraocular Pressure ◽  
The Impact

Time-Dependent Effects of Elevated Intraocular Pressure on Optic Nerve Head Axonal Transport and Cytoskeleton Proteins

2008 ◽  
Vol 49 (3) ◽  
pp. 986 ◽  
Author(s):  
Chandrakumar Balaratnasingam ◽  
William H. Morgan ◽  
Louise Bass ◽  
Stephen J. Cringle ◽  
Dao-Yi Yu
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Axonal Transport ◽  
Optic Nerve Head ◽  
Time Dependent ◽  
Elevated Intraocular Pressure

Stochastic Modeling to Identify the Normal Response of an Optic Nerve Head to Small Increases in Intraocular Pressure

2011 ◽  
Author(s):  
Ian A. Sigal ◽  
Jonathan L. Grimm
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Statistical Power ◽  
Lamina Cribrosa ◽  
Small Subset ◽  
Retinal Ganglion ◽  
Main Risk Factor ◽  
Elevated Intraocular Pressure ◽  
Subsequent Loss

Glaucoma is one of the leading causes of blindness worldwide. Although elevated intraocular pressure (IOP) is the main risk factor for the development of the disease, its role remains unclear. Several studies have explored the hypothesis that an IOP-induced altered biomechanical environment within the optic nerve head (ONH), and the lamina cribrosa in particular, may contribute to disruption of the retinal ganglion cell axons, and the subsequent loss of vision associated with glaucoma [1–3]. Identifying the normal ONH biomechanical environment, however, has proven challenging. This has been in part because of the difficulty in accessing the ONH directly for experimentation, but also because of the difficulty in reconstructing models of the relevant structures with which to estimate its biomechanics. Few models represent only a small subset of the possible variations in ONH characteristics in a population, with the consequent lack of statistical power in the predictions.

Sign in / Sign up

Export Citation Format

Share Document