Parametric Study of Sleeve Repair on Wrinkled Energy Pipelines

2010 ◽  
Author(s):  
Peter Song ◽  
J. J. Roger Cheng ◽  
Scott Ironside ◽  
Darren Skibinsky
Keyword(s):  
Phase I ◽  
Parametric Study ◽  
Phase I Study ◽  
Cost Effective ◽  
Repair System ◽  
Fe Method ◽  
Repair Work ◽  
Repair Technique ◽  
Cost Effective Method ◽  
Two Phases

Field experience showed that repairing wrinkles developed on energy pipelines using steel sleeves is an efficient and cost effective method. Based on the previous successful numerical simulations of a field wrinkle sleeve repair work, a parametric study was conducted by using Finite Element (FE) method to further investigate the effectiveness of the sleeve repair technique. The FE package ABAQUS 6.4 was utilized in conducting the parametric study. The parameters studied include the length, the thickness, and the material properties of the sleeve, and the thickness of the collar, which is used to fit between the wrinkled pipe and the repairing sleeve. The range of the parameters studied covers the most commonly used typical values in the pipeline industry. Two phases were used in carrying out the parametric study. In Phase I, the parameter that plays the most important role in determining the behavior of the wrinkle sleeve repair system (WSRS) was studied. It is found this parameter is the length of the repairing sleeve. Brief discussion was given regarding the way this parameter affects the behavior of the pipe using the WSRS. In Phase II, based on the results from the Phase I study, the effects of other parameters were investigated through a series of FE analyses. Conclusions were drawn and recommendations for future wrinkle sleeve repair work were given based on the results of the parametric study.

Phase I Study of Weekly Oxaliplatin in Relapsed or Refractory Pediatric Solid Malignancies

2008 ◽  
Vol 26 (27) ◽  
pp. 4394-4400 ◽  
Author(s):  
Birgit Geoerger ◽  
François Doz ◽  
Jean-Claude Gentet ◽  
Michele Mayer ◽  
Judith Landman-Parker ◽  
...  
Keyword(s):  
Phase I ◽  
Dose Escalation ◽  
Phase I Study ◽  
Maximum Tolerated Dose ◽  
Weekly Schedule ◽  
Open Label ◽  
Solid Malignancy ◽  
Phase Ii Studies ◽  
Solid Malignancies ◽  
Two Phases

Purpose To explore feasibility, maximum-tolerated dose (MTD), and recommended dose (RD) for phase II studies of weekly oxaliplatin for the treatment of relapsed or refractory pediatric solid malignancies. Patients and Methods Eligible patients were 6 months to 21 years old, had a diagnosis of a solid malignancy, and had experienced treatment failure with at least two or more previous lines of therapy. The phase I study was multicentric, open-label, and nonrandomized. It foresaw two phases: a dose-escalation phase (comprising six levels) to find the RD and an extension at the RD to evaluate the cumulative toxicity. Oxaliplatin was administered intravenously over 2 hours on days 1, 8, and 15 of a 28-day cycle. Results Forty-five patients were enrolled: 29 patients in the dose-escalation phase and 16 patients in the extension at the RD. Median age was 9.5 years (range, 2.8 to 20.0 years) and 7.8 years (range, 1.8 to 19.2 years), respectively. The dose-limiting toxicities during the first treatment cycle were grade 3 (G3) sepsis at 50 mg/m2, G3 dysesthesia at 90 mg/m2, and G3 dysesthesia and G3 paresthesia at 110 mg/m2, thus the MTD and RD was 90 mg/m2. No case of ototoxicity was reported. Stable disease was reported in seven patients (16.3%), and confirmed partial response was observed in two patients (4.7%), one with neuroblastoma and one with osteosarcoma. Conclusion Oxaliplatin administered in a weekly schedule has an acceptable safety profile, different from cisplatin and carboplatin, and shows activity in children with relapsed or refractory solid tumors, suggesting further investigation in pediatric malignancies.

CAD Of Anticorrosive Protection Of Steel Structures

2019 ◽  
pp. 18-23
Keyword(s):  
Protective Coating ◽  
Computer Aided Design ◽  
Steel Structures ◽  
Cost Effective ◽  
Operating Conditions ◽  
Computational Tool ◽  
Protection Method ◽  
Cost Effective Method ◽  
The Cost ◽  
Aided Design

The choice of cost-effective method of anticorrosive protection of steel structures is an urgent and time consuming task, considering the significant number of protection ways, differing from each other in the complex of technological, physical, chemical and economic characteristics. To reduce the complexity of solving this problem, the author proposes a computational tool that can be considered as a subsystem of computer-aided design and used at the stage of variant and detailed design of steel structures. As a criterion of the effectiveness of the anti-corrosion protection method, the cost of the protective coating during the service life is accepted. The analysis of existing methods of steel protection against corrosion is performed, the possibility of their use for the protection of the most common steel structures is established, as well as the estimated period of effective operation of the coating. The developed computational tool makes it possible to choose the best method of protection of steel structures against corrosion, taking into account the operating conditions of the protected structure and the possibility of using a protective coating.

Sign in / Sign up

Export Citation Format

Share Document