An Urinary Biosensor for Early Stage Ovarian Cancer Detection: Experimental Characterization

2012 ◽  
Author(s):  
Onursal Onen ◽  
Alper Sisman ◽  
Patricia Kruk ◽  
Rasim O. Guldiken
Keyword(s):  
Ovarian Cancer ◽  
Acoustic Waves ◽  
Early Stage ◽  
Point Of Care ◽  
Surface Acoustic Waves ◽  
Experimental Characterization ◽  
Apoptotic Protein ◽  
Polarized Surface ◽  
Shear Horizontal

In this study, an experimental characterization of a piezoelectric ultrasonic MEMS biosensor for detection of anti-apoptotic protein Bcl-2 in sub ng/ml scale is presented. Bcl-2 is demonstrated to be elevated at different stages of ovarian cancer in urine ranging from 0.5 to 12 ng/ml. Here, shear horizontal (SH) polarized surface acoustic waves (SAWs) were utilized by interdigital transducers (IDTs), which were micro fabricated on piezoelectric ST cut Quartz wafers. SH SAWs were generated and sensed by a pair of IDTs, separated by judiciously designed a delay path in-between with for most effective Bcl-2 capture. The Bcl-2 concentration is characterized with respect to the change in resonance frequency. The target sensitivity for diagnosis and quantifying the stage of ovarian cancer is achieved with successful detection of Bcl-2 levels as low as 0.5 ng/ml. The results are promising for the sensor system to be used in a lab-on-a-chip platform for point of care urinary ovarian cancer monitoring diagnosis.

Characterization of RF Sputtered ZnO Piezoelectric Films Using Transmission Electron Microscope

1975 ◽  
Vol 33 ◽  
pp. 86-87
Author(s):  
Kemining W. Yeh ◽  
Richard S. Muller ◽  
Wei-Kuo Wu ◽  
Jack Washburn
Keyword(s):  
Integrated Circuit ◽  
Acoustic Waves ◽  
New Technology ◽  
Surface Acoustic Waves ◽  
Electromechanical Properties ◽  
Leading Role ◽  
Saw Devices ◽  
Transmission Electron ◽  
High Degree

Considerable and continuing interest has been shown in the thin film transducer fabrication for surface acoustic waves (SAW) in the past few years. Due to the high degree of miniaturization, compatibility with silicon integrated circuit technology, simplicity and ease of design, this new technology has played an important role in the design of new devices for communications and signal processing. Among the commonly used piezoelectric thin films, ZnO generally yields superior electromechanical properties and is expected to play a leading role in the development of SAW devices.

scholarly journals Highly Sensitive Surface Acoustic Wave Magnetic Field Sensor Using Multilayered TbCo2/FeCo Thin Film

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 902 ◽  
Author(s):  
Aurelien Mazzamurro ◽  
Abdelkrim Talbi ◽  
Yannick Dusch ◽  
Omar Elmazria ◽  
Philippe Pernod ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Thin Film ◽  
Acoustic Waves ◽  
Surface Acoustic Waves ◽  
Magnetic Field Sensor ◽  
Nanostructured Thin Film ◽  
Highly Sensitive ◽  
Magnetic Model ◽  
Field Sensor

Over the last decades, the use of Surface Acoustic Waves (SAW) has emerged as a promising technology in many applications such as filters, signal processing but also sensors. We report the fabrication and the characterization of a SAW delay line magnetic field sensor using uniaxial multi-layered 14×[TbCo2(3.7nm)/FeCo(4nm)] nanostructured thin film deposited on Y36° Lithium Niobate (Figure 1a). The sensor shows an interesting dependency to a tunable bias magnetic field with different orientations relative to the easy axis. The obtained results are well explained using an equivalent piezo-magnetic model described in a previous work.

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