Optimization of Skin Cooling for Thermographic Imaging of Near-Surface Lesions

2011 ◽  
Author(s):  
Tze-Yuan Cheng ◽  
Cila Herman
Keyword(s):  
Thermal Imaging ◽  
Thermal Response ◽  
Skin Surface ◽  
Recovery Phase ◽  
The Body ◽  
Near Surface ◽  
Cooling Temperature ◽  
Cooling Conditions ◽  
Ir Imaging

With the dramatic advances in IR imaging technology, the IR imaging technique has the potential to become a promising non-contact in-vivo diagnostic tool for the early detection of melanoma [1] as well as other conditions in which the temperature of the body deviates from normal temperature. Active or dynamic IR (thermal) imaging, which involves introducing external cooling, can induce or enhance relevant thermal contrast observed on the skin surface, leading to temperature differences that can be accurately measured with a properly designed IR imaging system. When the skin surface is cooled down in active IR imaging, the variation in the thermal properties of the lesion located underneath the surface result in identifiable temperature differences from the surrounding healthy tissue in the recovery phase, and therefore the dynamic thermal response of the structure acquired using active imaging provides critical information to distinguish the diseased and healthy tissues. Regarding the effectiveness of the active IR imaging, in this study, the performance of varied cooling parameters, including cooling method, cooling temperature, cooling duration, and cooling depth are discussed. Toward the objective of minimizing the discomfort of patient, by evaluating the transient temperature difference in the recovery phase for varied cooling conditions, our goal is to find out the optimized cooling conditions, which can provide effective thermal response contrast in the recovery phase, while applying appropriate cooling temperature and duration to facilitate the clinical feasibility of this technique. The optimized cooling condition concluded from the simulation will be verified by the in-vivo dynamic thermal imaging experiments.

Thermal Imaging in Evaluation of the Physical Fitness Level

2017 ◽  
pp. 141-164 ◽  
Author(s):  
Teresa Kasprzyk ◽  
Agata Stanek ◽  
Karolina Sieroń-Stołtny ◽  
Armand Cholewka
Keyword(s):  
Thermal Imaging ◽  
Skin Surface ◽  
The Body ◽  
Body Core Temperature ◽  
Skin Surface Temperature ◽  
Fitness Level ◽  
Surface Temperature Distribution ◽  
Body Core ◽  
Cycle Training ◽  
Basic Level

The thermoregulation mechanisms during the physical effort can be easily study by using the thermovision. The thermoregulation mechanisms in human body keep the body core temperature on basic level 37 ± 2oC. However, the question is if there are any differences in skin surface temperature distribution between trainee sportsmen and amateur. Is there any possibility to show the sportsman level of practise using the thermal imaging? Would it be possible to evaluate the efficiency of athlete or evaluate the level of sports possibilities in average amateur who just wants to start cycle training. To find how the thermoregulation mechanisms work the different measurements were done i.e. during the cyclist endurance test for group of male cyclist (intermediate level of cycling skill) and during the Aerobic Circuit Training (ACT) for trainee and amateur group of women.

Thermal Imaging in Evaluation of the Physical Fitness Level

2021 ◽  
pp. 772-794
Author(s):  
Teresa Kasprzyk ◽  
Agata Stanek ◽  
Karolina Sieroń-Stołtny ◽  
Armand Cholewka
Keyword(s):  
Thermal Imaging ◽  
Skin Surface ◽  
The Body ◽  
Body Core Temperature ◽  
Skin Surface Temperature ◽  
Fitness Level ◽  
Surface Temperature Distribution ◽  
Body Core ◽  
Cycle Training ◽  
Basic Level

The thermoregulation mechanisms during the physical effort can be easily study by using the thermovision. The thermoregulation mechanisms in human body keep the body core temperature on basic level 37 ± 2 oC. However, the question is if there are any differences in skin surface temperature distribution between trainee sportsmen and amateur. Is there any possibility to show the sportsman level of practise using the thermal imaging? Would it be possible to evaluate the efficiency of athlete or evaluate the level of sports possibilities in average amateur who just wants to start cycle training. To find how the thermoregulation mechanisms work the different measurements were done i.e. during the cyclist endurance test for group of male cyclist (intermediate level of cycling skill) and during the Aerobic Circuit Training (ACT) for trainee and amateur group of women.

A preliminary study for the assessment of hypertension using static and dynamic IR thermograms

2018 ◽  
Vol 63 (2) ◽  
pp. 197-206
Author(s):  
Jayanthi Thiruvengadam ◽  
Anburajan Mariamichael
Keyword(s):  
Feature Selection ◽  
Thermal Imaging ◽  
Structural Changes ◽  
Principal Component ◽  
Normal Subjects ◽  
Skin Surface ◽  
The Body ◽  
Preliminary Study ◽  
Average Skin ◽  
Diagnosis Of Hypertension

AbstractStructural changes in blood vessels occur due to prolonged hypertension. Early detection of blood pressure (mm Hg) is essential for disease prevention. The aim of this work is to propose a computer-aided diagnostic (CADx) model for the diagnosis of hypertension using variables derived from non-contact static and dynamic thermal imaging in comparison with the pulse wave velocity (PWV)-derived parameters. Static and dynamic infrared (IR) thermograms of selected skin areas of the body from known hypertensive (n=14) and age- and sex-matched normal subjects were captured. The average skin surface temperature [SST (°C)] of selected skin areas of the body was calculated from a static IR thermogram. After denoising the dynamic IR thermogram using wavelets, the statistical variables power, mean, standard deviation (SD), variance, skewness and kurtosis were calculated. The variables derived from both static and dynamic thermograms were used to develop the CADx model. The performance of the CAD model was also tested by feature selection using principal component analysis (PCA). An accuracy of 75% (sensitivity=78.6%, specificity=71.4%) could be achieved with the average SST (°C) of the static IR thermogram alone. The statistical variables derived from the dynamic IR thermogram alone gave an accuracy of 82% (and 85% after feature selection by PCA), whereas the accuracy using standard methods like variables derived from PWV was only 71.4% (with and without feature selection). The highest accuracy of 89% could be achieved by combining variables like average SST (°C) measured from static and dynamic IR thermograms and PWV-derived variables.

scholarly journals Emperor penguin body surfaces cool below air temperature

2013 ◽  
Vol 9 (3) ◽  
pp. 20121192 ◽  
Author(s):  
D. J. McCafferty ◽  
C. Gilbert ◽  
A.-M. Thierry ◽  
J. Currie ◽  
Y. Le Maho ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Heat Loss ◽  
Thermal Imaging ◽  
Skin Surface ◽  
The Body ◽  
Emperor Penguin ◽  
Emperor Penguins ◽  
Heat Transfer Theory ◽  
Terre Adélie ◽  
Sky Conditions

Emperor penguins Aptenodytes forsteri are able to survive the harsh Antarctic climate because of specialized anatomical, physiological and behavioural adaptations for minimizing heat loss. Heat transfer theory predicts that metabolic heat loss in this species will mostly depend on radiative and convective cooling. To examine this, thermal imaging of emperor penguins was undertaken at the breeding colony of Pointe Géologie in Terre Adélie (66°40′ S 140° 01′ E), Antarctica in June 2008. During clear sky conditions, most outer surfaces of the body were colder than surrounding sub-zero air owing to radiative cooling. In these conditions, the feather surface will paradoxically gain heat by convection from surrounding air. However, owing to the low thermal conductivity of plumage any heat transfer to the skin surface will be negligible. Future thermal imaging studies are likely to yield further insights into the adaptations of this species to the Antarctic climate.

PREDICTING BIOLOGICAL AGE FROM A SKIN SURFACE CAPACITIVE ANALYSIS

2004 ◽  
Vol 15 (09) ◽  
pp. 1309-1320 ◽  
Author(s):  
ALESSANDRO BEVILACQUA ◽  
ALESSANDRO GHERARDI ◽  
MASSIMO FERRI
Keyword(s):  
Embedded System ◽  
Surface Characterization ◽  
Low Cost ◽  
Skin Surface ◽  
Skin Aging ◽  
The Body ◽  
Biological Age ◽  
Health Issues ◽  
Area Distribution

The skin is the largest (and the most exposed) organ of the body both in terms of surface area and weight. Its care is of great importance for both aesthetics and health issues. Often, the skin appearance gives us information about the skin health status as well as hints at the biological age. Therefore, the skin surface characterization is of great significance for dermatologists as well as for cosmetic scientists in order to evaluate the effectiveness of medical or cosmetic treatments. So far, no in vivo measurements regarding skin topography characterization could be achieved routinely to evaluate skin aging. This work describes how a portable capacitive device, normally used for fingerprint acquisition, can be utilized to achieve measures of skin aging routinely. The capacitive images give a high resolution (50 μm) representation of skin topography, in terms of wrinkles and cells. In this work, we have addressed the latter: through image segmentation techniques, cells have been localized and identified and a feature related to their area distribution has been generated. Accurate experiments accomplished in vivo show how the feature we conceived is linearly related to skin aging. Besides, since this finding has been achieved using a low cost portable device, this could boost research in this field as well as open doors to an application based on an embedded system.

The Role of Polyphenols in the Modulation of Plasma Non-Enzymatic Antioxidant Capacity (NEAC)

2012 ◽  
Vol 82 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Mauro Serafini ◽  
Giuseppa Morabito
Keyword(s):  
Antioxidant Capacity ◽  
Dietary Intervention ◽  
Ex Vivo ◽  
The Body ◽  
Dietary Polyphenols ◽  
Enzymatic Antioxidant ◽  
Endogenous Antioxidant

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

The Possible Function of sIgA on the Skin Surface in Vivo.

1995 ◽  
Vol 57 (1) ◽  
pp. 52-54 ◽  
Author(s):  
Takako GOTO ◽  
Takahiro GYOTOKU ◽  
Shuhei IMAYAMA ◽  
Yoshiaki HORI
Keyword(s):  
Skin Surface

Репрограммированые in vitro на М3 фенотип макрофаги останавливают рост солидной карциномы in vivo

2018 ◽  
pp. 41-46
Author(s):  
А.А. Раецкая ◽  
С.В. Калиш ◽  
С.В. Лямина ◽  
Е.В. Малышева ◽  
О.П. Буданова ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Antitumor Effect ◽  
Tumor Development ◽  
Significant Inhibition ◽  
The Body ◽  
Ehrlich Carcinoma ◽  
Solid Carcinoma ◽  
Ec Cells

Цель исследования. Доказательство гипотезы, что репрограммированные in vitro на М3 фенотип макрофаги при введении в организм будут существенно ограничивать развитие солидной карциномы in vivo . Методика. Рост солидной опухоли инициировали у мышей in vivo путем подкожной инъекции клеток карциномы Эрлиха (КЭ). Инъекцию макрофагов с нативным М0 фенотипом и с репрограммированным M3 фенотипом проводили в область формирования солидной КЭ. Репрограммирование проводили с помощью низких доз сыворотки, блокаторов факторов транскрипции STAT3/6 и SMAD3 и липополисахарида. Использовали две схемы введения макрофагов: раннее и позднее. При раннем введении макрофаги вводили на 1-е, 5-е, 10-е и 15-е сут. после инъекции клеток КЭ путем обкалывания макрофагами с четырех сторон область развития опухоли. При позднем введении, макрофаги вводили на 10-е, 15-е, 20-е и 25-е сут. Через 15 и 30 сут. после введения клеток КЭ солидную опухоль иссекали и измеряли ее объем. Эффект введения макрофагов оценивали качественно по визуальной и пальпаторной характеристикам солидной опухоли и количественно по изменению ее объема по сравнению с группой без введения макрофагов (контроль). Результаты. Установлено, что M3 макрофаги при раннем введении от начала развития опухоли оказывают выраженный антиопухолевый эффект in vivo , который был существенно более выражен, чем при позднем введении макрофагов. Заключение. Установлено, что введение репрограммированных макрофагов M3 ограничивает развитие солидной карциномы в экспериментах in vivo . Противоопухолевый эффект более выражен при раннем введении М3 макрофагов. Обнаруженные в работе факты делают перспективным разработку клинической версии биотехнологии ограничения роста опухоли, путем предварительного программирования антиопухолевого врожденного иммунного ответа «в пробирке». Aim. To verify a hypothesis that macrophages reprogrammed in vitro to the M3 phenotype and injected into the body substantially restrict the development of solid carcinoma in vivo . Methods. Growth of a solid tumor was initiated in mice in vivo with a subcutaneous injection of Ehrlich carcinoma (EC) cells. Macrophages with a native M0 phenotype or reprogrammed towards the M3 phenotype were injected into the region of developing solid EC. Reprogramming was performed using low doses of serum, STAT3/6 and SMAD3 transcription factor blockers, and lipopolysaccharide. Two schemes of macrophage administration were used: early and late. With the early administration, macrophages were injected on days 1, 5, 10, and 15 following the injection of EC cells at four sides of the tumor development area. With the late administration, macrophages were injected on days 10, 15, 20, and 25. At 15 and 30 days after the EC cell injection, the solid tumor was excised and its volume was measured. The effect of macrophage administration was assessed both qualitatively by visual and palpation characteristics of solid tumor and quantitatively by changes in the tumor volume compared with the group without the macrophage treatment. Results. M3 macrophages administered early after the onset of tumor development exerted a pronounced antitumor effect in vivo , which was significantly greater than the antitumor effect of the late administration of M3 macrophages. Conclusion. The observed significant inhibition of in vivo growth of solid carcinoma by M3 macrophages makes promising the development of a clinical version of the biotechnology for restriction of tumor growth by in vitro pre-programming of the antitumor, innate immune response.

Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy: From In Silico Prediction to In Vivo Applications

2020 ◽  
Author(s):  
Johannes Karges ◽  
Shi Kuang ◽  
Federica Maschietto ◽  
Olivier Blacque ◽  
Ilaria Ciofini ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Silico ◽  
Aqueous Solubility ◽  
The Body ◽  
Photon Absorption ◽  
Multicellular Tumor Spheroids ◽  
Spectral Window ◽  
Photon Excitation ◽  
Polypyridine Complexes

<div>The use of photodynamic therapy (PDT) against cancer has received increasing attention overthe recent years. However, the application of the currently approved photosensitizers (PSs) is somehow limited by their poor aqueous solubility, aggregation, photobleaching and slow clearance from the body. To overcome these limitations, there is a need for the development of new classes of PSs with ruthenium(II) polypyridine complexes currently gaining momentum. However, these compounds generally lack significant absorption in the biological spectral window, limiting their application to treat deep-seated or large tumors. To overcome this drawback, ruthenium(II) polypyridine complexes designed in silico with (E,E’)-4,4´-bisstyryl 2,2´-bipyridine ligands showed impressive 1- and 2-Photon absorption up to a magnitude higher than the ones published so far. While non-toxic in the dark, these compounds were found phototoxic in various 2D monolayer cells, 3D multicellular tumor spheroids and be able to eradicate a multiresistant tumor inside a mouse model upon clinically relevant 1-Photon and 2 Photon excitation.</div>

In-vivo evaluation of lipid lowering ability of Chloris paraguaiensis extracts

2020 ◽  
Vol 7 (2) ◽  
pp. 21-24
Author(s):  
Pavani C H
Keyword(s):  
Medicinal Plants ◽  
Chemical Constituents ◽  
The Body ◽  
Lipid Lowering ◽  
Medical Systems ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Anti Oxidant ◽  
And Control

Hyperlipidemia is the immediate results of the excessive fat intake in food. This results in the elevated levels of cholesterol and triglycerides in the blood. This leads to heart conditions like CAD, hypertension, congestive heart failure as risk factors which can be lethal. There are many drugs to treat and control the lipids levels in the body. These drugs are either designed to prevent LDL accumulation and VLDL synthesis. Some drugs also lower the elevated levels of saturated lipids in the body. But many drugs are known to cause side effects and adverse effects; therefore, alternatives to the drugs are the subjects for current investigations. Herbs and medicinal plants are used as treatment sources for many years. They have been used in the Indian medical systems like Ayurveda, Siddha etc. As the application of herbs in the treatment is growing, there is an urgent need for the establishment of Pharmacological reasoning and standardization of the activity of the medicinal plants. Chloris paraguaiensis Steud. is Poyaceae member that is called locally as Uppugaddi. Traditionally it is used to treat Rheumatism, Diabetes, fever and diarrhoea. The chemical constituents are known to have anti-oxidant properties and most of the anti-oxidants have anti-hyperlipidemic activity too. Since the plant has abundant flavonoid and phenol content, the current research focusses on the investigation of the anti-hyperlipidemic activity of the plant Chloris extracts. Extracts of Chloris at 200mg/kg showed a comparably similar anti hyperlipidemia activity to that of the standard drug. The extracts showed a dose based increase in the activity at 100 and 200mg/kg body weight.

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