Rapid Diagnosis of Inhomogeneity in Turbid Media

2003 ◽  
Author(s):  
Siew Kan Wan ◽  
Zhixiong Guo ◽  
Sunil Kumar
Keyword(s):  
Biological Tissues ◽  
Turbid Media ◽  
Scattering Media ◽  
Time Resolved ◽  
Object A ◽  
Tissue Phantom ◽  
Novel Approach ◽  
Novel Method ◽  
High Absorption

In this work, a novel approach is proposed that would be able to rapidly diagnose the presence and location of inhomogeneity in turbid media. In this approach, ultrafast pulse laser is used as a detecting source and the time-resolved backscattered light signals are collected around the boundary of the target. The log slopes in the decaying log tail of the detected signals will be analyzed and used for the detection and image of embedded inhomogeneity. The relatively high absorption in the foreign object will result in a steeper log slope when the detector is located close to the object. A slim graphite of 1.6 mm in diameter embedded in a tissue phantom has been successfully detected in a preliminary experiment and the location of the graphite is determined from the v-groove profile of log slopes. A Monte Carlo program has been developed to further simulate and investigate the feasibility and quality of this method to diagnose the presence of a tumor-like material embedded inside a highly scattering media. A 2D reconstructed image confirms the potential of this novel method to detect and image accurately and rapidly the presence of tumors in biological tissues.

Measurement of Fluorescence Properties in Light Scattering Medium

2011 ◽  
Author(s):  
Shoji Maruoka ◽  
Yohei Mitsui ◽  
Shinpei Okawa ◽  
Yoko Hoshi ◽  
Yukio Yamada
Keyword(s):  
Fluorescence Probe ◽  
Emission Spectra ◽  
Biological Tissues ◽  
Fluorescence Properties ◽  
Scattering Media ◽  
Fluorescent Properties ◽  
Time Resolved ◽  
Absorption And Emission ◽  
Absorption And Emission Spectra ◽  
Living Body

The purpose of this study is to measure the fluorescence properties of Indocyaninegreen (ICG) which is a fluorescence dye to be used as a fluorescence probe for the use of fluorescence imaging in biomedical applications. The fluorescence molecular imaging is expected to solve the issues in preclinical studies which require a lot of time, labors and sacrificed animals. Information of living body can be obtained by measuring the fluorescent properties of the probe in biological media. The absorption and emission spectra and the lifetime of ICG in non-scattering and scattering media were measured in this study. ICG was dissolved in water, in plasma, in Intralipid, and in a mixture of plasma and Intralipid to simulate the environment in living tissues. The absorption and emission spectra were measured using a fluorescence spectrophotometer. The fluorescence lifetimes were measured using a time-resolved measurement method. Results suggest that the fluorescent properties are affected by the reaction between ICG and biological tissues.

scholarly journals Fast 3D movement of a laser focusing spot behind scattering media by utilizing optical memory effect and optical conjugate planes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Vinh Tran ◽  
Sujit K. Sahoo ◽  
Cuong Dang
Keyword(s):  
Memory Effect ◽  
Light Propagation ◽  
Optical Memory ◽  
Biological Tissues ◽  
Frame Rate ◽  
Optimization Process ◽  
Turbid Media ◽  
Scattering Media ◽  
Focus Spot ◽  
Wavefront Shaping

AbstractControlling light propagation intentionally through turbid media such as ground glass or biological tissue has been demonstrated for many useful applications. Due to random scattering effect, one of the important goals is to draw a desired shape behind turbid media with a swift and precise method. Feedback wavefront shaping method which is known as a very effective approach to focus the light, is restricted by slow optimization process for obtaining multiple spots. Here we propose a technique to implement feedback wavefront shaping with optical memory effect and optical 4f system to speedy move focus spot and form shapes in 3D space behind scattering media. Starting with only one optimization process to achieve a focusing spot, the advantages of the optical configuration and full digital control allow us to move the focus spot with high quality at the speed of SLM frame rate. Multiple focusing spots can be achieved simultaneously by combining multiple phase patterns on a single SLM. By inheriting the phase patterns in the initial focusing process, we can enhance the intensity of the focusing spot at the edge of memory effect in with 50% reduction in optimization time. With a new focusing spot, we have two partially overlapped memory effect regions, expanding our 3D scanning range. With fast wavefront shaping devices, our proposed technique could potentially find appealing applications with biological tissues.

Imaging through Scattering Media with a Learning Based Prior

2020 ◽  
Vol 2020 (14) ◽  
pp. 306-1-306-6
Author(s):  
Florian Schiffers ◽  
Lionel Fiske ◽  
Pablo Ruiz ◽  
Aggelos K. Katsaggelos ◽  
Oliver Cossairt
Keyword(s):  
Optimization Problem ◽  
Autonomous Driving ◽  
Scattering Media ◽  
Photon Scattering ◽  
Point Spread ◽  
Spread Function ◽  
Radiative Transport Equation ◽  
Spatio Temporal ◽  
Transient Imaging

Imaging through scattering media finds applications in diverse fields from biomedicine to autonomous driving. However, interpreting the resulting images is difficult due to blur caused by the scattering of photons within the medium. Transient information, captured with fast temporal sensors, can be used to significantly improve the quality of images acquired in scattering conditions. Photon scattering, within a highly scattering media, is well modeled by the diffusion approximation of the Radiative Transport Equation (RTE). Its solution is easily derived which can be interpreted as a Spatio-Temporal Point Spread Function (STPSF). In this paper, we first discuss the properties of the ST-PSF and subsequently use this knowledge to simulate transient imaging through highly scattering media. We then propose a framework to invert the forward model, which assumes Poisson noise, to recover a noise-free, unblurred image by solving an optimization problem.

scholarly journals A novel approach to the computation of one-loop three- and four-point functions: I. The real mass case

2019 ◽  
Vol 2019 (11) ◽  
Author(s):  
J Ph Guillet ◽  
E Pilon ◽  
Y Shimizu ◽  
M S Zidi
Keyword(s):  
Building Blocks ◽  
The Real ◽  
Alternative Method ◽  
Novel Approach ◽  
Reduction Methods ◽  
Real Mass ◽  
Novel Method ◽  
Algebraic Reduction ◽  
The One ◽  
Mass Case

Abstract This article is the first of a series of three presenting an alternative method of computing the one-loop scalar integrals. This novel method enjoys a couple of interesting features as compared with the method closely following ’t Hooft and Veltman adopted previously. It directly proceeds in terms of the quantities driving algebraic reduction methods. It applies to the three-point functions and, in a similar way, to the four-point functions. It also extends to complex masses without much complication. Lastly, it extends to kinematics more general than that of the physical, e.g., collider processes relevant at one loop. This last feature may be useful when considering the application of this method beyond one loop using generalized one-loop integrals as building blocks.

scholarly journals One Song, Many Voices: Dementia and The Power of Music

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 775-775
Author(s):  
Debra Sheets ◽  
Stuart MacDonald ◽  
Andre Smith
Keyword(s):  
High School Students ◽  
Social Inclusion ◽  
Positive Impact ◽  
Social Connections ◽  
Social Connection ◽  
School Students ◽  
Choral Singing ◽  
Novel Approach ◽  
Care Partners

Abstract Choral singing is a novel approach to reduce dementia stigma and social isolation while offering participants a sense of purpose, joy and social connection. The pervasiveness of stigma surrounding dementia remains one of the biggest barriers to living life with dignity following a diagnosis (Alzheimer Society of Canada, 2018). This paper examines how a social inclusion model of dementia care involving an intergenerational choir for people living with dementia, their care partners and high school students can reduce stigma and foster social connections. Multiple methodologies are used to investigate the effects of choir participation on cognition, stress levels, social connections, stigma, and quality of life. Results demonstrate the positive impact of choir participation and indicate that this socially inclusive intervention offers an effective, non-pharmacological alternative for older adults living with dementia in the community. Discussion focuses on the importance of instituting meaningful and engaging dementia-friendly activities at the community level.

scholarly journals AI-based localization and classification of skin disease with erythema

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ha Min Son ◽  
Wooho Jeon ◽  
Jinhyun Kim ◽  
Chan Yeong Heo ◽  
Hye Jin Yoon ◽  
...  
Keyword(s):  
Neural Network ◽  
Skin Diseases ◽  
Classification Model ◽  
Screening Tests ◽  
Sensitivity Score ◽  
Common Skin ◽  
Novel Method ◽  
Improved Performance ◽  
High Level

AbstractAlthough computer-aided diagnosis (CAD) is used to improve the quality of diagnosis in various medical fields such as mammography and colonography, it is not used in dermatology, where noninvasive screening tests are performed only with the naked eye, and avoidable inaccuracies may exist. This study shows that CAD may also be a viable option in dermatology by presenting a novel method to sequentially combine accurate segmentation and classification models. Given an image of the skin, we decompose the image to normalize and extract high-level features. Using a neural network-based segmentation model to create a segmented map of the image, we then cluster sections of abnormal skin and pass this information to a classification model. We classify each cluster into different common skin diseases using another neural network model. Our segmentation model achieves better performance compared to previous studies, and also achieves a near-perfect sensitivity score in unfavorable conditions. Our classification model is more accurate than a baseline model trained without segmentation, while also being able to classify multiple diseases within a single image. This improved performance may be sufficient to use CAD in the field of dermatology.

scholarly journals A novel p-harmonic descent approach applied to fluid dynamic shape optimization

2021 ◽  
Author(s):  
Peter Marvin Müller ◽  
Niklas Kühl ◽  
Martin Siebenborn ◽  
Klaus Deckelnick ◽  
Michael Hinze ◽  
...  
Keyword(s):  
Shape Optimization ◽  
Large Deformations ◽  
Fluid Dynamic ◽  
Shape Optimisation ◽  
Shape Features ◽  
Floating Bodies ◽  
Novel Method ◽  
Sharp Corners ◽  
Dynamic Shape

AbstractWe introduce a novel method for the implementation of shape optimization for non-parameterized shapes in fluid dynamics applications, where we propose to use the shape derivative to determine deformation fields with the help of the $$p-$$ p - Laplacian for $$p > 2$$ p > 2 . This approach is closely related to the computation of steepest descent directions of the shape functional in the $$W^{1,\infty }-$$ W 1 , ∞ - topology and refers to the recent publication Deckelnick et al. (A novel $$W^{1,\infty}$$ W 1 , ∞ approach to shape optimisation with Lipschitz domains, 2021), where this idea is proposed. Our approach is demonstrated for shape optimization related to drag-minimal free floating bodies. The method is validated against existing approaches with respect to convergence of the optimization algorithm, the obtained shape, and regarding the quality of the computational grid after large deformations. Our numerical results strongly indicate that shape optimization related to the $$W^{1,\infty }$$ W 1 , ∞ -topology—though numerically more demanding—seems to be superior over the classical approaches invoking Hilbert space methods, concerning the convergence, the obtained shapes and the mesh quality after large deformations, in particular when the optimal shape features sharp corners.

scholarly journals ART-UP: A Novel Method for Generating Scanning-Robust Aesthetic QR Codes

2021 ◽  
Vol 17 (1) ◽  
pp. 1-23
Author(s):  
Mingliang Xu ◽  
Qingfeng Li ◽  
Jianwei Niu ◽  
Hao Su ◽  
Xiting Liu ◽  
...  
Keyword(s):  
State Of The Art ◽  
Visual Quality ◽  
Qr Code ◽  
Quick Response ◽  
Estimation Model ◽  
Qr Codes ◽  
Excellent Performance ◽  
Novel Method ◽  
Coarse To Fine

Quick response (QR) codes are usually scanned in different environments, so they must be robust to variations in illumination, scale, coverage, and camera angles. Aesthetic QR codes improve the visual quality, but subtle changes in their appearance may cause scanning failure. In this article, a new method to generate scanning-robust aesthetic QR codes is proposed, which is based on a module-based scanning probability estimation model that can effectively balance the tradeoff between visual quality and scanning robustness. Our method locally adjusts the luminance of each module by estimating the probability of successful sampling. The approach adopts the hierarchical, coarse-to-fine strategy to enhance the visual quality of aesthetic QR codes, which sequentially generate the following three codes: a binary aesthetic QR code, a grayscale aesthetic QR code, and the final color aesthetic QR code. Our approach also can be used to create QR codes with different visual styles by adjusting some initialization parameters. User surveys and decoding experiments were adopted for evaluating our method compared with state-of-the-art algorithms, which indicates that the proposed approach has excellent performance in terms of both visual quality and scanning robustness.

scholarly journals A Novel Approach for Comparison of Reception Performance in a Technique Test and Small-Sided Games

Sports ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 66
Author(s):  
Arne Sørensen ◽  
Vidar Sørensen ◽  
Terje Dalen
Keyword(s):  
Correlation Coefficient ◽  
Rank Order ◽  
Technical Skills ◽  
Quality Score ◽  
Soccer Players ◽  
Moderate Correlation ◽  
Technical Aspects ◽  
Youth Soccer ◽  
Novel Approach

The purpose of this study was to evaluate the correlation between soccer players’ performance of receptions of passes in tests of both isolated technical skills and more match-realistic situations in small-sided games (SSGs). In addition, this study investigated whether the involvement in SSGs (number of receptions) correlated with the quality of receptions in the respective SSGs. The participants were 13 male outfield youth soccer players from teams in the first division of the regional U18 league. The quality of receptions was scored by educated coaches according to set criteria of performance. Statistical analyses of correlations were determined using Spearman’s rank-order correlation coefficient (rs). The main results were (1) a significant correlation in the quality of ball reception between 4vs1 SSGs and 5vs5 SSGs (rs = −0.61, p < 0.01) and (2) a trend towards moderate correlation between the quality of ball reception using a ball projection machine and 5vs5 SSGs (rs = −0.48, p = 0.10). (3) A significant correlation was found between the number of receptions in 5vs5 SSGs and the quality score of receptions in 5vs5 SSGs (rs = −0.70, p < 0.01). The trend towards moderate correlations between 5vs5 SSGs and the isolated technical reception test could imply the importance of training in the technical aspects of ball reception. Moreover, it seems as though the players with the best reception performance are the players who are most involved in SSGs, that is, having the most receptions.

scholarly journals AB0050 A NOVEL METHOD FOR ISOLATION OF EXOSOMES FROM SYNOVIAL FLUID

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1057.2-1057
Author(s):  
Y. Liu ◽  
Y. Huang ◽  
Q. Huang ◽  
S. Sun ◽  
Z. Ji ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Western Blot ◽  
Biological Fluid ◽  
High Sensitivity ◽  
Protein Distribution ◽  
Sds Page ◽  
Close Relationship ◽  
Novel Method ◽  
Low Levels

Background:Exosomes in synovial fluid (SF) has a close relationship with the pathogenesis of rheumatiod arthritis. As a complex biological fluid, SF presents challenges for exosomes isolation using standard methods, such as ExoquickTM kit and ultracentrifugation.Objectives:The study aims to compared the quality of exosomes separated by ExoquickTM kit (TM), ExoquickTM kit+ExoquickTC kit (TM-TC), ultracentrifugation (UC) and TM-TC+UC(TM-TC-UC) from SF.Methods:Exosomes was separated by TM, TM-TC, UC and TM-TC-UC respectively. The size and concentrations of exosomes were detected by high sensitivity flow cytometry for nanoparticle analysis. Total protein and RNA were extracted from exosomes. SDS-PAGE was used to detect the protein distribution of exosomes. Western blot was used to examine the level of albumin and exosomes marker (TSG101 and CD81).Results:There was no statistic difference in the diameters of exosomes separated by the four methods. The concentrations of exosomes in TM, TM-TC, TM-TC-UC and UC were (5.65±0.93), (3.02±1.19), (1.67±0.25) and (4.61±0.73) *109Particles/mL. The protein concentrations of exosomes separated by the four methods were consistent with the concentrations of exosomes. SDS-PAGE showed that the protein distribution of exosomes separated by the four methods were different. Low levels of albumin were detected in TM-TC and TM-TC-UC, while high levels of albumin in TM and UC. Total RNA concentrations from exosomes in TM-TC was higher than other groups.Conclusion:TM-TC can be used to obtain higher quality exosomes from SF for the study of exosome-enriched components.References:[1]Helwa I, et al, A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents. PloS one, 2017. 12(1): p. e0170628-e0170628.Figure 1.A: SDS-PAGE showed the protein distribution of exosomes; B: the detection of albumin, TSG101 and CD81 by western blot.Disclosure of Interests:None declared

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